Artificial pancreas: glycemic control strategies for avoiding hypoglycemia
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Redalyc
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Universidad Nacional de Colombia
2018
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| _version_ | 1876433611714985984 |
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| author | Juan E. Sereno |
| author_facet | Juan E. Sereno |
| contents | Artificial pancreas: glycemic control strategies for avoiding hypoglycemia Juan E. Sereno Michelle A. Caicedo Pablo S. Rivadeneira Ingeniería robustness PID control performance Artificial pancreas diabetes mellitus type 1 This paper examines the performance of two new closed-loop control strategies developed as part of the Artificial Pancreas project, this being the most promising treatment for type 1 diabetes mellitus. The first strategy uses a new version of the well-known proportional, integral and derivative control, developed to respect state and input positivity constraints. The second is a new formulation of model-based predictive control with an impulsive input. The strategies’ performance is evaluated with 50 virtual patients taken from the literature and the UVa/Padova metabolic simulator, approved by the US Food and Drug Administration. Also, a robustness analysis is added to evaluate the strategies under the parametric variations of the most important physiological parameters. The results show that both strategies have a good performance with low to moderate plant-model mismatch. 2018 artículo científico 0012-7353 https://www.redalyc.org/articulo.oa?id=49658894026 https://www.redalyc.org/journal/496/49658894026/ https://www.redalyc.org/journal/496/49658894026/html/ https://www.redalyc.org/journal/496/49658894026/49658894026.epub https://www.redalyc.org/journal/496/49658894026/movil 10.15446/dyna.v85n207.71535 en http://www.redalyc.org/revista.oa?id=496 Dyna application/pdf Universidad Nacional de Colombia Dyna (Colombia) Num.207 Vol.85 |
| format | Artículo científico |
| id | redalyc_49658894026 |
| institution | Redalyc |
| language | en |
| publishDate | 2018 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Artificial pancreas: glycemic control strategies for avoiding hypoglycemia Juan E. Sereno Ingeniería robustness PID control performance Artificial pancreas diabetes mellitus type 1 Artificial pancreas: glycemic control strategies for avoiding hypoglycemia Juan E. Sereno Michelle A. Caicedo Pablo S. Rivadeneira Ingeniería robustness PID control performance Artificial pancreas diabetes mellitus type 1 This paper examines the performance of two new closed-loop control strategies developed as part of the Artificial Pancreas project, this being the most promising treatment for type 1 diabetes mellitus. The first strategy uses a new version of the well-known proportional, integral and derivative control, developed to respect state and input positivity constraints. The second is a new formulation of model-based predictive control with an impulsive input. The strategies’ performance is evaluated with 50 virtual patients taken from the literature and the UVa/Padova metabolic simulator, approved by the US Food and Drug Administration. Also, a robustness analysis is added to evaluate the strategies under the parametric variations of the most important physiological parameters. The results show that both strategies have a good performance with low to moderate plant-model mismatch. 2018 artículo científico 0012-7353 https://www.redalyc.org/articulo.oa?id=49658894026 https://www.redalyc.org/journal/496/49658894026/ https://www.redalyc.org/journal/496/49658894026/html/ https://www.redalyc.org/journal/496/49658894026/49658894026.epub https://www.redalyc.org/journal/496/49658894026/movil 10.15446/dyna.v85n207.71535 en http://www.redalyc.org/revista.oa?id=496 Dyna application/pdf Universidad Nacional de Colombia Dyna (Colombia) Num.207 Vol.85 |
| title | Artificial pancreas: glycemic control strategies for avoiding hypoglycemia |
| topic | Ingeniería robustness PID control performance Artificial pancreas diabetes mellitus type 1 |
| url | https://www.redalyc.org/articulo.oa?id=49658894026 https://www.redalyc.org/journal/496/49658894026/ https://www.redalyc.org/journal/496/49658894026/html/ https://www.redalyc.org/journal/496/49658894026/49658894026.epub https://www.redalyc.org/journal/496/49658894026/movil |