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| Formato: | Artículo científico |
| Lenguaje: | en |
| Publicado: |
Universidad de Costa Rica
2022
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| Acceso en línea: | https://www.redalyc.org/articulo.oa?id=499570300015 https://www.redalyc.org/journal/4995/499570300015/ https://www.redalyc.org/journal/4995/499570300015/html/ https://www.redalyc.org/journal/4995/499570300015/499570300015.epub https://www.redalyc.org/journal/4995/499570300015/movil |
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- Quantification of Sphingosine-1-Phosphate (S1P) in Patients with Periodontitis Stage II Grade B María I. García-Parra Matilde Jiménez-Coello Bertha A. Carrillo-Ávila Eduardo A. Sauri-Esquivel Víctor M. Martínez-Aguilar Elda G. Chávez-Cortéz Medicina Saliva Phosphate Sphingosine Inflammation Periodontitis The aim of this study was the quantification of Sphingosine-1-phosphate (S1P) in periodontal pockets of patients with periodontitis. This is an observational, descriptive, case-control study. Thirty subjects were selected: 15 controls and 15 cases. A periodontal study was conducted following the parameters of AAP 2017 for the diagnosis of periodontal diseases. A sample of saliva and gingival crevicular fluid was obtained from each subject and then analyzed with the Human S1P Elisa kit (MyBioSource #MBS2516132) accordingly to the manufacturer's instructions, in order to verify the presence of S1P and quantify it´s concentration when founded. Results showed a significant difference (p=0.05) between cases and controls. In the case of saliva samples, the concentration of S1P was higher than the ones found in the control group (72.94 ng/mL and 45.12 ng/mL). For GCF, a higher amount of S1P was found in patients with POD (20.09 ng/mL and 15.20 ng/mL). This work raises a possible route of bone metabolism, inflammatory process, and identification of periodontitis through oral quantification of S1P, however, future studies are needed. 2022 artículo científico 1659-1046 https://www.redalyc.org/articulo.oa?id=499570300015 https://www.redalyc.org/journal/4995/499570300015/ https://www.redalyc.org/journal/4995/499570300015/html/ https://www.redalyc.org/journal/4995/499570300015/499570300015.epub https://www.redalyc.org/journal/4995/499570300015/movil 10.15517/IJDS.2022.48877 en http://www.redalyc.org/revista.oa?id=4995 Odovtos - International Journal of Dental Sciences application/pdf Universidad de Costa Rica Odovtos - International Journal of Dental Sciences (Costa Rica) Num.1 Vol.24