Salivary Cytokine Profile in Patients with Oral Lichen Planus
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad de Costa Rica
2024
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| _version_ | 1876433627640758272 |
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| author | Janaina Silva Martins Humberto |
| author_facet | Janaina Silva Martins Humberto |
| contents | Salivary Cytokine Profile in Patients with Oral Lichen Planus Janaina Silva Martins Humberto Rafael Simone Saia Luis Henrique Angenendt Costa Maria José Alves Rocha Ana Carolina Fragoso Motta Medicina Cortisol Cytokines Interleukin Nitric oxide Oral lichen planus This study aimed to determine salivary concentrations of interleukin (IL)-1β, IL-2, IL-10, IL- 23, transforming growth factor (TGF)-β, tumor necrosis factor (TNF)-α, nitrate (a by-product of nitric oxide oxidation), and cortisol in patients with oral lichen planus (OLP). Twenty patients diagnosed with OLP and 20 sex-matched healthy volunteers (HV) were included in this cross-sectional study. Unstimulated whole saliva was collected in the morning. Salivary cytokine and cortisol concentrations were determined by enzyme-linked immunosorbent assays (ELISA). Nitrate was measured in a nitric oxide analyzer. We found higher salivary concentrations of IL-2 (p<0.003), IL-23 ( p<0.04), and TGF-β (p=0.05) in patients with OLP compared to HV. No significant differences were found in salivary levels of TNF-α, IL-1β, or IL-10. Nitrate concentrations were markedly increased in OLP patients (1,227.0 ± 738.8 µM/mg total protein) when compared to HV (261.6 ± 166.8 µM/mg; p<0.0001). Salivary cortisol levels were also higher in OLP patients (2.79 ± 1.39 vs. 1.94 ±1.21 ng/mg; p<0.048). The markedly increased salivary levels of nitric oxide in patients with OLP suggest a relationship of this molecule with the cell death and tissue damage observed in these lesions. 2024 artículo científico 1659-1046 https://www.redalyc.org/articulo.oa?id=499578904012 https://www.redalyc.org/journal/4995/499578904012/ https://www.redalyc.org/journal/4995/499578904012/html/ https://www.redalyc.org/journal/4995/499578904012/499578904012.epub https://www.redalyc.org/journal/4995/499578904012/movil 10.15517/ijds.2023.57139 en http://www.redalyc.org/revista.oa?id=4995 Odovtos - International Journal of Dental Sciences application/pdf Universidad de Costa Rica Odovtos - International Journal of Dental Sciences (Costa Rica) Num.2 Vol.26 |
| format | Artículo científico |
| id | redalyc_499578904012 |
| institution | Redalyc |
| language | en |
| publishDate | 2024 |
| publisher | Universidad de Costa Rica |
| spellingShingle | Salivary Cytokine Profile in Patients with Oral Lichen Planus Janaina Silva Martins Humberto Medicina Cortisol Cytokines Interleukin Nitric oxide Oral lichen planus Salivary Cytokine Profile in Patients with Oral Lichen Planus Janaina Silva Martins Humberto Rafael Simone Saia Luis Henrique Angenendt Costa Maria José Alves Rocha Ana Carolina Fragoso Motta Medicina Cortisol Cytokines Interleukin Nitric oxide Oral lichen planus This study aimed to determine salivary concentrations of interleukin (IL)-1β, IL-2, IL-10, IL- 23, transforming growth factor (TGF)-β, tumor necrosis factor (TNF)-α, nitrate (a by-product of nitric oxide oxidation), and cortisol in patients with oral lichen planus (OLP). Twenty patients diagnosed with OLP and 20 sex-matched healthy volunteers (HV) were included in this cross-sectional study. Unstimulated whole saliva was collected in the morning. Salivary cytokine and cortisol concentrations were determined by enzyme-linked immunosorbent assays (ELISA). Nitrate was measured in a nitric oxide analyzer. We found higher salivary concentrations of IL-2 (p<0.003), IL-23 ( p<0.04), and TGF-β (p=0.05) in patients with OLP compared to HV. No significant differences were found in salivary levels of TNF-α, IL-1β, or IL-10. Nitrate concentrations were markedly increased in OLP patients (1,227.0 ± 738.8 µM/mg total protein) when compared to HV (261.6 ± 166.8 µM/mg; p<0.0001). Salivary cortisol levels were also higher in OLP patients (2.79 ± 1.39 vs. 1.94 ±1.21 ng/mg; p<0.048). The markedly increased salivary levels of nitric oxide in patients with OLP suggest a relationship of this molecule with the cell death and tissue damage observed in these lesions. 2024 artículo científico 1659-1046 https://www.redalyc.org/articulo.oa?id=499578904012 https://www.redalyc.org/journal/4995/499578904012/ https://www.redalyc.org/journal/4995/499578904012/html/ https://www.redalyc.org/journal/4995/499578904012/499578904012.epub https://www.redalyc.org/journal/4995/499578904012/movil 10.15517/ijds.2023.57139 en http://www.redalyc.org/revista.oa?id=4995 Odovtos - International Journal of Dental Sciences application/pdf Universidad de Costa Rica Odovtos - International Journal of Dental Sciences (Costa Rica) Num.2 Vol.26 |
| title | Salivary Cytokine Profile in Patients with Oral Lichen Planus |
| topic | Medicina Cortisol Cytokines Interleukin Nitric oxide Oral lichen planus |
| url | https://www.redalyc.org/articulo.oa?id=499578904012 https://www.redalyc.org/journal/4995/499578904012/ https://www.redalyc.org/journal/4995/499578904012/html/ https://www.redalyc.org/journal/4995/499578904012/499578904012.epub https://www.redalyc.org/journal/4995/499578904012/movil |