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Main Author:	Héctor Adarmes
Format:	Artículo científico
Language:	en
Published:	Universidad Austral de Chile 2017
Subjects:	Veterinaria joint Equine cartilage glycosaminoglycans
Online Access:	https://www.redalyc.org/articulo.oa?id=501753483012
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author	Héctor Adarmes
author_facet	Héctor Adarmes
contents	Glycosaminoglycans (GAGs) determination in healthy and damaged equine articular cartilage Héctor Adarmes Leonardo Donders Cristóbal Dörner Ema González Marco Galleguillos Veterinaria joint Equine cartilage glycosaminoglycans The purpose of this study was to establish if there was any difference in the GAGs content between loaded and unloaded surfaces of the joint. Furthermore, the results were compared between macroscopically healthy and damaged joints. Cartilage samples were obtained from two different zones of the equine metacarpophalangeal joint (metacarpal condyles). Samples were collected from the loaded surface of macroscopically healthy joints (N1; n=10) and from macroscopically damaged cartilage (P1; n=10). Additionally, cartilage samples were collected from unloaded areas at the most dorso-proximal zone of the joint in macroscopically healthy joints (N2; n=10) and from the macroscopically pathological joints but without damaged cartilage on the site of sampling (P2; n=10). The GAGs were extracted from 100 mg of cartilage of each sample and quantified through the safranine - O method that measured the total anionic charges, and through the carbazole method that measured the uronic acid content. Both methods measured the GAGs content, showing no differences between intra-joint zones (1 and 2), but when the GAGs content was compared between healthy and pathological joints, both methods showed a significantly decreased GAGs content in the damaged joints (1 and 2). These results show that the whole articular cartilage could be affected in a chronic pathological process and is not only a local process occ urring in the macroscopically damaged cartilage associated with the loaded area. 2017 artículo científico 0719-8000 https://www.redalyc.org/articulo.oa?id=501753483012 en http://www.redalyc.org/revista.oa?id=5017 Austral Journal of Veterinary Sciences application/pdf Universidad Austral de Chile Austral Journal of Veterinary Sciences (Chile) Num.2 Vol.49
format	Artículo científico
id	redalyc_501753483012
language	en
publishDate	2017
publisher	Universidad Austral de Chile
spellingShingle	Glycosaminoglycans (GAGs) determination in healthy and damaged equine articular cartilage Héctor Adarmes Veterinaria joint Equine cartilage glycosaminoglycans Glycosaminoglycans (GAGs) determination in healthy and damaged equine articular cartilage Héctor Adarmes Leonardo Donders Cristóbal Dörner Ema González Marco Galleguillos Veterinaria joint Equine cartilage glycosaminoglycans The purpose of this study was to establish if there was any difference in the GAGs content between loaded and unloaded surfaces of the joint. Furthermore, the results were compared between macroscopically healthy and damaged joints. Cartilage samples were obtained from two different zones of the equine metacarpophalangeal joint (metacarpal condyles). Samples were collected from the loaded surface of macroscopically healthy joints (N1; n=10) and from macroscopically damaged cartilage (P1; n=10). Additionally, cartilage samples were collected from unloaded areas at the most dorso-proximal zone of the joint in macroscopically healthy joints (N2; n=10) and from the macroscopically pathological joints but without damaged cartilage on the site of sampling (P2; n=10). The GAGs were extracted from 100 mg of cartilage of each sample and quantified through the safranine - O method that measured the total anionic charges, and through the carbazole method that measured the uronic acid content. Both methods measured the GAGs content, showing no differences between intra-joint zones (1 and 2), but when the GAGs content was compared between healthy and pathological joints, both methods showed a significantly decreased GAGs content in the damaged joints (1 and 2). These results show that the whole articular cartilage could be affected in a chronic pathological process and is not only a local process occ urring in the macroscopically damaged cartilage associated with the loaded area. 2017 artículo científico 0719-8000 https://www.redalyc.org/articulo.oa?id=501753483012 en http://www.redalyc.org/revista.oa?id=5017 Austral Journal of Veterinary Sciences application/pdf Universidad Austral de Chile Austral Journal of Veterinary Sciences (Chile) Num.2 Vol.49
title	Glycosaminoglycans (GAGs) determination in healthy and damaged equine articular cartilage
topic	Veterinaria joint Equine cartilage glycosaminoglycans
url	https://www.redalyc.org/articulo.oa?id=501753483012

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