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| Format: | Artículo científico |
| Language: | en |
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Federación Bioquímica de la Provincia de Buenos Aires
2006
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| Online Access: | https://www.redalyc.org/articulo.oa?id=53540208 |
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Table of Contents:
- Action of calcium binders. Formation of calcium salts in the intestinal tract and the blood circulatory system César Martínez Yaquelo Biología osteopenia calcinosis osteoporosis urolithyasis calcium binders Calcium binders are water- soluble substances whose anionic part can possiblyreact with calcium cations present in any part of the human body. Someexamples of calcium binders are phosphoric, oxalic and phytic acids and theiralkaline salts present in many natural foods, in some foods containing additives,and in some medicines. There are also uric and lactic acids that are theresult of normal metabolism. The first negative action of calcium binderstakes place in the intestinal tract when they react with calcium of dairy food.The latter produces a combination of calcium binder anions with calciumcations, and then an insoluble salt that precipitates as small solid particlesthat cannot be assimilated and which are eliminated in the faeces. The secondnegative action of calcium binders takes place when soluble calciumbinders are assimilated into the blood circulatory system and get in contactwith the free ionized calcium in serum, which gives rise to complexed calciumwith inorganic and organic anions. Immediately the free ionized normallevel of calcium in blood serum decays, and the parathyroid hormone comesinto action (secondary hyperparathyroidism) extracting free ionized calciumfrom bones (bone resorption). The soluble complexed calcium circulates inthe serum through the whole blood circulatory system, and because it is ultrafiltrable,it freely filters through the glomerulus and is excreted in urine. Thefinal result is the formation of the corresponding salts in a metastable state,concentrated near the point where the precipitation of these salts occurs. Thisspecial condition is due to the fact that certain proteins are inhibiting the precipitation.In some soft tissues with chronic inflammation, the above-mentionedmetastable state is affected because the inhibitory mechanism isblocked, causing the formation of calcium phosphate salts nuclei in the tissueand the build up of calcium phosphate crystals. This triggers causesmany serious diseases. Finally, it is suggested that a start can be made onpreventing the action of calcium binders by controlling diet, especially byavoiding high intakes of phosphates, oxalates and phytates. 2006 artículo científico 0325-2957 https://www.redalyc.org/articulo.oa?id=53540208 en http://www.redalyc.org/revista.oa?id=535 Acta Bioquímica Clínica Latinoamericana application/pdf Federación Bioquímica de la Provincia de Buenos Aires Acta Bioquímica Clínica Latinoamericana (Argentina) Num.2 Vol.40