Potencial de oxidación de las Lipoproteínas de baja densidad en una población normal y en una población con diabetes mellitus tipo 2
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| Format: | Artículo científico |
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Sociedad Venezolana de Farmacología Clínica y Terapéutica
2004
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| author | M del C Lares |
| author_facet | M del C Lares |
| contents | Potencial de oxidación de las Lipoproteínas de baja densidad en una población normal y en una población con diabetes mellitus tipo 2 M del C Lares G Garzazo O Obregón J Castro Medicina Malondialdehyde (MDA) Diabetes mellitus type 2 and LDL The lipids peroxidation is a complex process, where unsaturated fatty acids react with molecular oxygen by a mechanism of chain reaction via free radicals, form hidroperoxides which are degraded to a variety of products like alkenals, hidroxialquenals, ketones, alkenos, and others, which can be quantified by different methodologies, like malondialdehyde (MDA), a final product of the degradation of fatty acids. In the present work we determined the susceptibility of low density lipoproteins to be oxidized, in two populations one normal (n=30) between 25-35 years and other with diabetes type 2 (n=25) between 25-50 years, without previous treatment of antioxidant. The extraction of the LDL by ultracentrifugation, oxidized in vitro, and then MDA was determined by the thiobarbituric acid method. The results of malondialdehyde in the normal population was between 0,77 to 1,17μmol/L and in the diabetics population from 1,47 to 2,11 μmol/L with stadistic difference between both population. In conclusion, the normal values of MDA are from 0,77 to 1,17μmol/L, greater values could be indicative of additional risk in these patients 2004 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55923105 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.1 Vol.23 |
| format | Artículo científico |
| id | redalyc_55923105 |
| institution | Redalyc |
| language | en |
| publishDate | 2004 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | Potencial de oxidación de las Lipoproteínas de baja densidad en una población normal y en una población con diabetes mellitus tipo 2 M del C Lares Medicina Malondialdehyde (MDA) Diabetes mellitus type 2 and LDL Potencial de oxidación de las Lipoproteínas de baja densidad en una población normal y en una población con diabetes mellitus tipo 2 M del C Lares G Garzazo O Obregón J Castro Medicina Malondialdehyde (MDA) Diabetes mellitus type 2 and LDL The lipids peroxidation is a complex process, where unsaturated fatty acids react with molecular oxygen by a mechanism of chain reaction via free radicals, form hidroperoxides which are degraded to a variety of products like alkenals, hidroxialquenals, ketones, alkenos, and others, which can be quantified by different methodologies, like malondialdehyde (MDA), a final product of the degradation of fatty acids. In the present work we determined the susceptibility of low density lipoproteins to be oxidized, in two populations one normal (n=30) between 25-35 years and other with diabetes type 2 (n=25) between 25-50 years, without previous treatment of antioxidant. The extraction of the LDL by ultracentrifugation, oxidized in vitro, and then MDA was determined by the thiobarbituric acid method. The results of malondialdehyde in the normal population was between 0,77 to 1,17μmol/L and in the diabetics population from 1,47 to 2,11 μmol/L with stadistic difference between both population. In conclusion, the normal values of MDA are from 0,77 to 1,17μmol/L, greater values could be indicative of additional risk in these patients 2004 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55923105 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.1 Vol.23 |
| title | Potencial de oxidación de las Lipoproteínas de baja densidad en una población normal y en una población con diabetes mellitus tipo 2 |
| topic | Medicina Malondialdehyde (MDA) Diabetes mellitus type 2 and LDL |
| url | https://www.redalyc.org/articulo.oa?id=55923105 |