El Sistema Nervioso Simpático Cerebral y la natriuresis inducida por la administración central de endotelinas
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| Format: | Artículo científico |
| Language: | en |
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Sociedad Venezolana de Farmacología Clínica y Terapéutica
2004
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| _version_ | 1866817172822556672 |
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| author | A. Israel |
| author_facet | A. Israel |
| contents | El Sistema Nervioso Simpático Cerebral y la natriuresis inducida por la administración central de endotelinas A. Israel M. Pastorello E. Díaz E. Camacho O. Torres Medicina Endothelin Sodium excretion Cerebroventricular Adrenergic receptors Experiments were conducted to investigate the role of brain the α1- α2 and β-adrenergic receptors on the renal effects elicited by central injection of ETs. Cerebroventricular administration of endothelins (ETs) to conscious male hydrated rats resulted in an increase in urinary sodium excretion at 1, 3 and 6 hr period of urine collection. Central administration of prazosin (an α1-adrenergic receptor antagonist) inhibited the increase in sodium and urine excretion induced by ICV-ETs. Yohimbine (an α2-adrenergic receptor antagonist) or atenolol (an β-adrenergic receptor antagonist) did not altered the urinary response to ET-IVT. Our results demonstrate a role for brain endothelin in the regulation of electrolyte balance and indicate that the sympathetic nervous system, through the α1-adrenergic receptor subtype, is involved in the natriuretic action of ETs 2004 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55923110 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.1 Vol.23 |
| format | Artículo científico |
| id | redalyc_55923110 |
| language | en |
| publishDate | 2004 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | El Sistema Nervioso Simpático Cerebral y la natriuresis inducida por la administración central de endotelinas A. Israel Medicina Endothelin Sodium excretion Cerebroventricular Adrenergic receptors El Sistema Nervioso Simpático Cerebral y la natriuresis inducida por la administración central de endotelinas A. Israel M. Pastorello E. Díaz E. Camacho O. Torres Medicina Endothelin Sodium excretion Cerebroventricular Adrenergic receptors Experiments were conducted to investigate the role of brain the α1- α2 and β-adrenergic receptors on the renal effects elicited by central injection of ETs. Cerebroventricular administration of endothelins (ETs) to conscious male hydrated rats resulted in an increase in urinary sodium excretion at 1, 3 and 6 hr period of urine collection. Central administration of prazosin (an α1-adrenergic receptor antagonist) inhibited the increase in sodium and urine excretion induced by ICV-ETs. Yohimbine (an α2-adrenergic receptor antagonist) or atenolol (an β-adrenergic receptor antagonist) did not altered the urinary response to ET-IVT. Our results demonstrate a role for brain endothelin in the regulation of electrolyte balance and indicate that the sympathetic nervous system, through the α1-adrenergic receptor subtype, is involved in the natriuretic action of ETs 2004 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55923110 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.1 Vol.23 |
| title | El Sistema Nervioso Simpático Cerebral y la natriuresis inducida por la administración central de endotelinas |
| topic | Medicina Endothelin Sodium excretion Cerebroventricular Adrenergic receptors |
| url | https://www.redalyc.org/articulo.oa?id=55923110 |