The mechanism of cancer involves short interfering RNA (siRNA)
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Sociedad Venezolana de Farmacología Clínica y Terapéutica
2008
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| _version_ | 1876472497368465408 |
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| author | Coral Wynter |
| author_facet | Coral Wynter |
| contents | The mechanism of cancer involves short interfering RNA (siRNA) Coral Wynter Marcelo Alfonzo Itala Lippo de Becemberg Medicina LOH RNAi siRNA Cáncer microRNA The recent discoveries of the RNA-mediated interference system in cells could explain all of the known features of human carcinogenesis. A novel idea, proposed here, is that the cell has the ability to recognize a mutated protein and/or mRNA. Secondly, the cell can generate its own short interfering RNA (siRNA) using an RNA polymerase to destroy mutated mRNA, even when only a single base pair in the gene has mutated. The anti-sense strand of the short RNA molecule (called sicRNA), targets the mutated mRNA of an oncogene or a tumour suppressor. During cell mitosis, the sicRNA complex can move into the nucleus to target the mutated gene. The sicRNA triggers the assembly of protein complexes leading to epigenetic modification of the promoter site of the mutant gene. In some instances, instead of methylation, the homologous DNA is degraded, leading to loss of heterozygosity. The factors controlling these two actions are unknown but the result is gene silencing or physical destruction of the mutant gene. An error in RNAi defence occurs when the sicRNA during methylation of the target gene, inadvertently interferes with the production of a miRNA specific for that tissue. This produces a change in the profile of correct proteins for that tissue. On a rare occasion, a preneoplastic stem cell will survive if miRNA interference switches on/off a gene involved in apoptosis, as well as a gene involved in cell proliferation and DNA damage surveillance. The driving force of carcinogenesis is the sequential loss of specific miRNAs. 2008 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55927104 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.1 Vol.27 |
| format | Artículo científico |
| id | redalyc_55927104 |
| institution | Redalyc |
| language | en |
| publishDate | 2008 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | The mechanism of cancer involves short interfering RNA (siRNA) Coral Wynter Medicina LOH RNAi siRNA Cáncer microRNA The mechanism of cancer involves short interfering RNA (siRNA) Coral Wynter Marcelo Alfonzo Itala Lippo de Becemberg Medicina LOH RNAi siRNA Cáncer microRNA The recent discoveries of the RNA-mediated interference system in cells could explain all of the known features of human carcinogenesis. A novel idea, proposed here, is that the cell has the ability to recognize a mutated protein and/or mRNA. Secondly, the cell can generate its own short interfering RNA (siRNA) using an RNA polymerase to destroy mutated mRNA, even when only a single base pair in the gene has mutated. The anti-sense strand of the short RNA molecule (called sicRNA), targets the mutated mRNA of an oncogene or a tumour suppressor. During cell mitosis, the sicRNA complex can move into the nucleus to target the mutated gene. The sicRNA triggers the assembly of protein complexes leading to epigenetic modification of the promoter site of the mutant gene. In some instances, instead of methylation, the homologous DNA is degraded, leading to loss of heterozygosity. The factors controlling these two actions are unknown but the result is gene silencing or physical destruction of the mutant gene. An error in RNAi defence occurs when the sicRNA during methylation of the target gene, inadvertently interferes with the production of a miRNA specific for that tissue. This produces a change in the profile of correct proteins for that tissue. On a rare occasion, a preneoplastic stem cell will survive if miRNA interference switches on/off a gene involved in apoptosis, as well as a gene involved in cell proliferation and DNA damage surveillance. The driving force of carcinogenesis is the sequential loss of specific miRNAs. 2008 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55927104 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.1 Vol.27 |
| title | The mechanism of cancer involves short interfering RNA (siRNA) |
| topic | Medicina LOH RNAi siRNA Cáncer microRNA |
| url | https://www.redalyc.org/articulo.oa?id=55927104 |