Mast cell activation disease associated with autoimmune thyroid disease: case report and review of literature
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedad Venezolana de Farmacología Clínica y Terapéutica
2016
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| _version_ | 1876450531034005504 |
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| author | Joselyn Rojas |
| author_facet | Joselyn Rojas |
| contents | Mast cell activation disease associated with autoimmune thyroid disease: case report and review of literature Joselyn Rojas María José Calvo Delgado Carmen Chávez Mervin Chávez-Castillo Lidia Mejía Juan Salazar Luis Olivar Modesto Graterol-Rivas Sandra Wilches-Duran Julio Contreras-Velásquez Rosemily Graterol-Silva Valmore Bermúdez Medicina mine hista mastocytosis facial flushing autoimmune thyroid disease Mast Cell Activation Disease (MCAD) is characterized by abnormal proliferation of mastocytes, where clinical manifes - tations arise from the excess release of these cells’ media - tors. This case report concerns a 34-year old male patient who seeks medical attention after 5 months presenting re - curring episodes of intense facial flushing with local edema, erythema, and increased volume of the ears and lips, with - out signs of angioedema. Other symptoms included burning oropharyngeal pain, vascular-type headache and hypoten - sion. These crises occurred predominantly during nighttime and lasted 20-60 minutes, and were often associated with prolonged exposure to sunlight, high temperatures and psy - chological stress; constituting a clinical picture compatible with MCAD, supported by laboratory findings. Treatment be - gan with ebastine, deflazacort, montelukast, ranitidine and omega-3 fatty acids, without clinical improvement, leading to substitution of this regimen with sodium chromoglycate and initiation of an immunomodulatory diet. This plan achieved satisfactory symptomatic resolution, confirming the diagno - sis and highlighting the importance of adequate pharmaco - logic intervention. During a control consultation, the patient reported nocturnal episodes of tachycardia, palpitations and anxiety unrelated to the flushing crises, which prompted thy - roid evaluation, revealing autoimmune thyroid disease with subclinical hyperthyroidism, which was managed with me - thimazol without complications. 2016 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55949908003 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.4 Vol.35 |
| format | Artículo científico |
| id | redalyc_55949908003 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | Mast cell activation disease associated with autoimmune thyroid disease: case report and review of literature Joselyn Rojas Medicina mine hista mastocytosis facial flushing autoimmune thyroid disease Mast cell activation disease associated with autoimmune thyroid disease: case report and review of literature Joselyn Rojas María José Calvo Delgado Carmen Chávez Mervin Chávez-Castillo Lidia Mejía Juan Salazar Luis Olivar Modesto Graterol-Rivas Sandra Wilches-Duran Julio Contreras-Velásquez Rosemily Graterol-Silva Valmore Bermúdez Medicina mine hista mastocytosis facial flushing autoimmune thyroid disease Mast Cell Activation Disease (MCAD) is characterized by abnormal proliferation of mastocytes, where clinical manifes - tations arise from the excess release of these cells’ media - tors. This case report concerns a 34-year old male patient who seeks medical attention after 5 months presenting re - curring episodes of intense facial flushing with local edema, erythema, and increased volume of the ears and lips, with - out signs of angioedema. Other symptoms included burning oropharyngeal pain, vascular-type headache and hypoten - sion. These crises occurred predominantly during nighttime and lasted 20-60 minutes, and were often associated with prolonged exposure to sunlight, high temperatures and psy - chological stress; constituting a clinical picture compatible with MCAD, supported by laboratory findings. Treatment be - gan with ebastine, deflazacort, montelukast, ranitidine and omega-3 fatty acids, without clinical improvement, leading to substitution of this regimen with sodium chromoglycate and initiation of an immunomodulatory diet. This plan achieved satisfactory symptomatic resolution, confirming the diagno - sis and highlighting the importance of adequate pharmaco - logic intervention. During a control consultation, the patient reported nocturnal episodes of tachycardia, palpitations and anxiety unrelated to the flushing crises, which prompted thy - roid evaluation, revealing autoimmune thyroid disease with subclinical hyperthyroidism, which was managed with me - thimazol without complications. 2016 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55949908003 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.4 Vol.35 |
| title | Mast cell activation disease associated with autoimmune thyroid disease: case report and review of literature |
| topic | Medicina mine hista mastocytosis facial flushing autoimmune thyroid disease |
| url | https://www.redalyc.org/articulo.oa?id=55949908003 |