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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sociedad Venezolana de Farmacología Clínica y Terapéutica
2020
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=55965386008 https://www.redalyc.org/journal/559/55965386008/ https://www.redalyc.org/journal/559/55965386008/html/ https://www.redalyc.org/journal/559/55965386008/55965386008.epub https://www.redalyc.org/journal/559/55965386008/movil https://doi.org/10.5281/zenodo.4265179 |
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Sommario:
- Endothelial protective properties of short-chain peptides that mimic α-helix B of erythropoietin in experimental preeclampsia Ivan V Golubev Vladimir V Gureev Mikhail V Korokin Anastasia V. Gureeva Adelaida V. Polyanskaya Mikhail V Pokrovskii Galina A Lazareva Natalia A. Bystrova Medicina rats proteinuria preeclampsia Erythropoietin microcirculation Objective. Investigate the endothelioprotective properties of short-chain derivatives of erythropoietin in experimental preeclampsia. Methodology. The experiment was performed in 100 white female Wistar rats weighing 250-300 g. L-NAME was administered intraperitoneally (25 mg/kg/day) from 14 to 20 days of pregnancy. The studied peptides (50 μg/kg) were administered intraperitoneally once a day from 10 to 20 days of pregnancy. On the 21st day of pregnancy, functional tests and laboratory tests were performed. Results. Rat pretreatment with the studied peptides reverted pathological changes in experimental ADMA-like preeclampsia. The greatest effect was observed with the peptide with the laboratory code P-αB1. A significant decrease in systolic and diastolic blood pressure was observed, improved microcirculation in the placenta, restoration of the endothelium NO-synthesizing function, and a decrease in proteinuria. Conclusion. The results of the study are promising for the use of short-chain derivatives of erythropoietin simulating its α-helix B for the correction of morpho-functional changes in experimental preeclampsia and substantiate the desirability of further research in this direction. 2020 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55965386008 https://www.redalyc.org/journal/559/55965386008/ https://www.redalyc.org/journal/559/55965386008/html/ https://www.redalyc.org/journal/559/55965386008/55965386008.epub https://www.redalyc.org/journal/559/55965386008/movil https://doi.org/10.5281/zenodo.4265179 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.5 Vol.39