Effect of Alpha2-Adrenoreceptors activation on rat heart chronotropy
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| Format: | Artículo científico |
| Language: | en |
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Sociedad Venezolana de Farmacología Clínica y Terapéutica
2020
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| author | Luiza Irekovna Khisamieva |
| author_facet | Luiza Irekovna Khisamieva |
| contents | Effect of Alpha2-Adrenoreceptors activation on rat heart chronotropy Luiza Irekovna Khisamieva Kobzarev Roman Sergeevich Miller Arnold Geinrikhovich Nafisa Ilgizovna Ziyatdinova Timur Lvovich Zefirov Medicina ST 91 rat Heart agonist A cardiovascular disease is a group of diseases of the heart and blood vessels. The most common cause of death in humans is associated precisely with cardiovascular diseases, and α.-adrenergic receptors (α.-AR) are known to be involved. α.-AR reduce the central sympathetic output and peripheral release of catecholamines and therefore, can prevent sympathetic hyperactivity and hypertension. Therefore, various agonists and antagonists of adrenergic receptors are widely used in the treatment of cardiovascular diseases in medicine, among them clonidine and ST-91. The objective was to compare the effects of clonidine and ST-91, selective agonists of α.-AR, on the cardiac activity in rats. Stimulation of α.-AR by ST-91 (0.01 mg/kg) causes a short-term negative chronotropic effect, while stimulation of α.-adrenergic receptors with clonidine (0.01 mg/kg) led to a negative chronotropic effect throughout the experiment. We hypothesize that the short-term effect of ST-91 on heart rate is associated with the activation of one of the three subtypes of α.-adrenergic receptors. Identification of the specific subtype due to which this effect was observed is part of future research.ith the activation of one of the three subtypes of α2-adrenergic receptors. Identification of the specific subtype due to which this effect was observed is part of future research. 2020 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55965388010 https://www.redalyc.org/journal/559/55965388010/ https://www.redalyc.org/journal/559/55965388010/html/ https://www.redalyc.org/journal/559/55965388010/55965388010.epub https://www.redalyc.org/journal/559/55965388010/movil https://doi.org/10.5281/zenodo.4424550 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.7 Vol.39 |
| format | Artículo científico |
| id | redalyc_55965388010 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | Effect of Alpha2-Adrenoreceptors activation on rat heart chronotropy Luiza Irekovna Khisamieva Medicina ST 91 rat Heart agonist Effect of Alpha2-Adrenoreceptors activation on rat heart chronotropy Luiza Irekovna Khisamieva Kobzarev Roman Sergeevich Miller Arnold Geinrikhovich Nafisa Ilgizovna Ziyatdinova Timur Lvovich Zefirov Medicina ST 91 rat Heart agonist A cardiovascular disease is a group of diseases of the heart and blood vessels. The most common cause of death in humans is associated precisely with cardiovascular diseases, and α.-adrenergic receptors (α.-AR) are known to be involved. α.-AR reduce the central sympathetic output and peripheral release of catecholamines and therefore, can prevent sympathetic hyperactivity and hypertension. Therefore, various agonists and antagonists of adrenergic receptors are widely used in the treatment of cardiovascular diseases in medicine, among them clonidine and ST-91. The objective was to compare the effects of clonidine and ST-91, selective agonists of α.-AR, on the cardiac activity in rats. Stimulation of α.-AR by ST-91 (0.01 mg/kg) causes a short-term negative chronotropic effect, while stimulation of α.-adrenergic receptors with clonidine (0.01 mg/kg) led to a negative chronotropic effect throughout the experiment. We hypothesize that the short-term effect of ST-91 on heart rate is associated with the activation of one of the three subtypes of α.-adrenergic receptors. Identification of the specific subtype due to which this effect was observed is part of future research.ith the activation of one of the three subtypes of α2-adrenergic receptors. Identification of the specific subtype due to which this effect was observed is part of future research. 2020 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55965388010 https://www.redalyc.org/journal/559/55965388010/ https://www.redalyc.org/journal/559/55965388010/html/ https://www.redalyc.org/journal/559/55965388010/55965388010.epub https://www.redalyc.org/journal/559/55965388010/movil https://doi.org/10.5281/zenodo.4424550 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.7 Vol.39 |
| title | Effect of Alpha2-Adrenoreceptors activation on rat heart chronotropy |
| topic | Medicina ST 91 rat Heart agonist |
| url | https://www.redalyc.org/articulo.oa?id=55965388010 https://www.redalyc.org/journal/559/55965388010/ https://www.redalyc.org/journal/559/55965388010/html/ https://www.redalyc.org/journal/559/55965388010/55965388010.epub https://www.redalyc.org/journal/559/55965388010/movil https://doi.org/10.5281/zenodo.4424550 |