The role of glycosylated hemoglobin in the development of Alzheimer’s disease in elderly patients with uncontrolled diabetes mellitus type 2 in Baquba city
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Sociedad Venezolana de Farmacología Clínica y Terapéutica
2021
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| author | Fuad Zeina F |
| author_facet | Fuad Zeina F |
| contents | The role of glycosylated hemoglobin in the development of Alzheimer’s disease in elderly patients with uncontrolled diabetes mellitus type 2 in Baquba city Fuad Zeina F M Mohammed Mohmmod Bushra Medicina Baquba city elderly patients Alzheimer’s disease Glycosylated hemoglobin uncontrolled diabetes mellitus type 2 Background: the link between Alzheimer’s disease and diabetes continues to grow stronger. Many studies have shown an association between Diabetes mellitus and cognitive function disorders. glycosylated hemoglobin has been proposed as biomarker has a great potential to predict dementia and cognitive decline in uncontrolled Diabetes. Research suggests that poorly controlled Diabetes can impact the Cognitive functionality of the patients in a negative way. Further, based on the literature the Alzheimer’s type Dementia is found to be linked with the uncontrolled type 2 Diabetes Mellitus This study aims to assess the role of glycosylated hemoglobin in the development of Alzheimer’s disease in elderly patients with uncontrolled type 2 Diabetes mellitus. Methods: Twenty-six type 2 diabetic patients and twenty-six control healthy subjects were enrolled in this study. Glycosylated hemoglobin was measured to all of them, twice during the study period and the mini-mental status examination was determined at the beginning and the end of the study.Results: case-control study for 52 patients with dementia, 26 patients with Diabetes mellitus and 26 normal patients, mean age of 68 ± 2 years old, with diabetic duration 3 ±1 years. The first examination of diabetic patients shows 85% of them with normal symptoms of dementia, while 11% moderate and 4% mild symptoms. After 2nd examination after average 2-3 years, show 46% normal, 31% mild, 15% moderate and 8% severe symptoms. There was a significant difference between HbA1c first and HbA1c second evaluation between diabetic and normal patients’ group. In the first and second evaluation HbA1c was higher in the diabetic group when compared with normal group. Conclusion: During both periods of evaluation, there was a significant difference between HbA1c in diabetic and normal patients’ group with Alzheimer’s disease in elderly patients with uncontrolled diabetes mellitus type 2. 2021 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55969711004 https://www.redalyc.org/journal/559/55969711004/ https://www.redalyc.org/journal/559/55969711004/html/ https://www.redalyc.org/journal/559/55969711004/55969711004.epub https://www.redalyc.org/journal/559/55969711004/movil https://doi.org/10.5281/zenodo.5449455 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.5 Vol.40 |
| format | Artículo científico |
| id | redalyc_55969711004 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | The role of glycosylated hemoglobin in the development of Alzheimer’s disease in elderly patients with uncontrolled diabetes mellitus type 2 in Baquba city Fuad Zeina F Medicina Baquba city elderly patients Alzheimer’s disease Glycosylated hemoglobin uncontrolled diabetes mellitus type 2 The role of glycosylated hemoglobin in the development of Alzheimer’s disease in elderly patients with uncontrolled diabetes mellitus type 2 in Baquba city Fuad Zeina F M Mohammed Mohmmod Bushra Medicina Baquba city elderly patients Alzheimer’s disease Glycosylated hemoglobin uncontrolled diabetes mellitus type 2 Background: the link between Alzheimer’s disease and diabetes continues to grow stronger. Many studies have shown an association between Diabetes mellitus and cognitive function disorders. glycosylated hemoglobin has been proposed as biomarker has a great potential to predict dementia and cognitive decline in uncontrolled Diabetes. Research suggests that poorly controlled Diabetes can impact the Cognitive functionality of the patients in a negative way. Further, based on the literature the Alzheimer’s type Dementia is found to be linked with the uncontrolled type 2 Diabetes Mellitus This study aims to assess the role of glycosylated hemoglobin in the development of Alzheimer’s disease in elderly patients with uncontrolled type 2 Diabetes mellitus. Methods: Twenty-six type 2 diabetic patients and twenty-six control healthy subjects were enrolled in this study. Glycosylated hemoglobin was measured to all of them, twice during the study period and the mini-mental status examination was determined at the beginning and the end of the study.Results: case-control study for 52 patients with dementia, 26 patients with Diabetes mellitus and 26 normal patients, mean age of 68 ± 2 years old, with diabetic duration 3 ±1 years. The first examination of diabetic patients shows 85% of them with normal symptoms of dementia, while 11% moderate and 4% mild symptoms. After 2nd examination after average 2-3 years, show 46% normal, 31% mild, 15% moderate and 8% severe symptoms. There was a significant difference between HbA1c first and HbA1c second evaluation between diabetic and normal patients’ group. In the first and second evaluation HbA1c was higher in the diabetic group when compared with normal group. Conclusion: During both periods of evaluation, there was a significant difference between HbA1c in diabetic and normal patients’ group with Alzheimer’s disease in elderly patients with uncontrolled diabetes mellitus type 2. 2021 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55969711004 https://www.redalyc.org/journal/559/55969711004/ https://www.redalyc.org/journal/559/55969711004/html/ https://www.redalyc.org/journal/559/55969711004/55969711004.epub https://www.redalyc.org/journal/559/55969711004/movil https://doi.org/10.5281/zenodo.5449455 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.5 Vol.40 |
| title | The role of glycosylated hemoglobin in the development of Alzheimer’s disease in elderly patients with uncontrolled diabetes mellitus type 2 in Baquba city |
| topic | Medicina Baquba city elderly patients Alzheimer’s disease Glycosylated hemoglobin uncontrolled diabetes mellitus type 2 |
| url | https://www.redalyc.org/articulo.oa?id=55969711004 https://www.redalyc.org/journal/559/55969711004/ https://www.redalyc.org/journal/559/55969711004/html/ https://www.redalyc.org/journal/559/55969711004/55969711004.epub https://www.redalyc.org/journal/559/55969711004/movil https://doi.org/10.5281/zenodo.5449455 |