The study of serum ferritin level as a predictor of growth retardation in Thalassemia-major
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| Natura: | Artículo científico |
| Lingua: | en |
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Sociedad Venezolana de Farmacología Clínica y Terapéutica
2021
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| _version_ | 1876442543199092736 |
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| author | Bash Hala Saad |
| author_facet | Bash Hala Saad |
| contents | The study of serum ferritin level as a predictor of growth retardation in Thalassemia-major Bash Hala Saad Al-Hindy Hayder Abdul-A.M. Al-Mamory Basheer Hussein JM Mazin Medicina ferritin iron overload thalassemia major Growth retardation Objective: This work aims to estimate serum ferritin levels of the B-thalassemia major (BTM) patients in one of the Iraqi thalassemia centers and to evaluate its relationship with their retarded growth. Methods: this was a cross-sectional study that included 163-patients diagnosed with BTM, undergoing continuous red cells transfusion and chelation therapy. The patients' serum ferritin, height, weight, and body mass index (BMI) was measured. The patients were classified into three groups based on their growth states. All the qualitative parameters were displayed as numerical data and percentages, though the quantitative parameters had displayed as mean ± SD. The variations amongst the 3-groups were analyzed by ANOVA test. The regression fit curves between serum ferritin and growth variables were evaluated. The ROC was examined for ferritin value and growth failure. A .<5% was considered as significant. Results: The mean age of the studied subjects were 12.6±3.5 years (range 3–19 years). The mean serum ferritin levels were 1812 ±1024.9 ng/mL, which showed a significant correlation with height, weight, and age. The mean height Z-score was -2.1±1.1, and 70% of the patients had growth failure (GF). The mean weight Z-score was -2.0 ±1.3. Both height and weight had a significant correlation with ferritin levels in BTM patients. ROC-curves revealed a sensitivity, specificity, and CI% of 72%,78% & (0.703-0.858), respectively for predictability of serum ferritin for GF in BTM patients. Conclusion: In BTM patients, the overall incidence of GF (both mild and severe form) was more than 70%. The mean serum ferritin levels correlated significantly with the growth retardation of BTM patients. 2021 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55969711006 https://www.redalyc.org/journal/559/55969711006/ https://www.redalyc.org/journal/559/55969711006/html/ https://www.redalyc.org/journal/559/55969711006/55969711006.epub https://www.redalyc.org/journal/559/55969711006/movil https://doi.org/10.5281/zenodo.5449803 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.5 Vol.40 |
| format | Artículo científico |
| id | redalyc_55969711006 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | The study of serum ferritin level as a predictor of growth retardation in Thalassemia-major Bash Hala Saad Medicina ferritin iron overload thalassemia major Growth retardation The study of serum ferritin level as a predictor of growth retardation in Thalassemia-major Bash Hala Saad Al-Hindy Hayder Abdul-A.M. Al-Mamory Basheer Hussein JM Mazin Medicina ferritin iron overload thalassemia major Growth retardation Objective: This work aims to estimate serum ferritin levels of the B-thalassemia major (BTM) patients in one of the Iraqi thalassemia centers and to evaluate its relationship with their retarded growth. Methods: this was a cross-sectional study that included 163-patients diagnosed with BTM, undergoing continuous red cells transfusion and chelation therapy. The patients' serum ferritin, height, weight, and body mass index (BMI) was measured. The patients were classified into three groups based on their growth states. All the qualitative parameters were displayed as numerical data and percentages, though the quantitative parameters had displayed as mean ± SD. The variations amongst the 3-groups were analyzed by ANOVA test. The regression fit curves between serum ferritin and growth variables were evaluated. The ROC was examined for ferritin value and growth failure. A .<5% was considered as significant. Results: The mean age of the studied subjects were 12.6±3.5 years (range 3–19 years). The mean serum ferritin levels were 1812 ±1024.9 ng/mL, which showed a significant correlation with height, weight, and age. The mean height Z-score was -2.1±1.1, and 70% of the patients had growth failure (GF). The mean weight Z-score was -2.0 ±1.3. Both height and weight had a significant correlation with ferritin levels in BTM patients. ROC-curves revealed a sensitivity, specificity, and CI% of 72%,78% & (0.703-0.858), respectively for predictability of serum ferritin for GF in BTM patients. Conclusion: In BTM patients, the overall incidence of GF (both mild and severe form) was more than 70%. The mean serum ferritin levels correlated significantly with the growth retardation of BTM patients. 2021 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55969711006 https://www.redalyc.org/journal/559/55969711006/ https://www.redalyc.org/journal/559/55969711006/html/ https://www.redalyc.org/journal/559/55969711006/55969711006.epub https://www.redalyc.org/journal/559/55969711006/movil https://doi.org/10.5281/zenodo.5449803 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.5 Vol.40 |
| title | The study of serum ferritin level as a predictor of growth retardation in Thalassemia-major |
| topic | Medicina ferritin iron overload thalassemia major Growth retardation |
| url | https://www.redalyc.org/articulo.oa?id=55969711006 https://www.redalyc.org/journal/559/55969711006/ https://www.redalyc.org/journal/559/55969711006/html/ https://www.redalyc.org/journal/559/55969711006/55969711006.epub https://www.redalyc.org/journal/559/55969711006/movil https://doi.org/10.5281/zenodo.5449803 |