Fast dissolving film nanocrystal (FDFN) preparation as a new trend for solubility enhancement of poorly soluble class ii drug tenoxicam
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| Format: | Artículo científico |
| Sprache: | en |
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Sociedad Venezolana de Farmacología Clínica y Terapéutica
2021
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| _version_ | 1876486570275504128 |
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| author | Furqan M. Abdulelah |
| author_facet | Furqan M. Abdulelah |
| contents | Fast dissolving film nanocrystal (FDFN) preparation as a new trend for solubility enhancement of poorly soluble class ii drug tenoxicam Furqan M. Abdulelah Mustafa R. Abdulbaqi Medicina poor solubility Tenoxicam (TNX) nanocrystal fast dissolving film nanocrystal (FDFN) Objective: This research targeted to prepare, characterize and evaluate fast dissolving film nanocrystals (FDFN) of tenoxicam (TNX) as an innovative system using three different film-former polymers, HPMC E 30, PVP K90 and PVA, for the optimization of BCS class II drug solubility, dissolution rate and bioavailability. Methods: TNX nanocrystals first prepared using acid-base nanoprecipitation method, which further formulated into fifteen FDF using HPMC E 30, PVP K90 and PVA as film-formers. Films were then evaluated for appearance, surface pH, folding endurance, thickness, weight variation, TS, PE, disintegration time and TNX release durations. Results: TNX nanocrystal were prepared successfully with optimized physical properties including solubility due size reduction. Six formulation, F-1, F-2, F-6, F-8, F-11 and F-12, exhibit desired FDF features as indicated by characterization techniques including fast disintegration in less than 30 seconds and in vitro dissolution within two minutes. Conclusion: Six TNX-FDFN formulations were prepared successfully with ideal film properties and improved TNX solubility and hence, can used as an alternative to the oral form thereby avoiding associated limitations of GI irritation and poor solubility of TNX. 2021 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55971452001 https://www.redalyc.org/journal/559/55971452001/ https://www.redalyc.org/journal/559/55971452001/html/ https://www.redalyc.org/journal/559/55971452001/55971452001.epub https://www.redalyc.org/journal/559/55971452001/movil https://doi.org/10.5281/zenodo.5218600 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.4 Vol.40 |
| format | Artículo científico |
| id | redalyc_55971452001 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | Fast dissolving film nanocrystal (FDFN) preparation as a new trend for solubility enhancement of poorly soluble class ii drug tenoxicam Furqan M. Abdulelah Medicina poor solubility Tenoxicam (TNX) nanocrystal fast dissolving film nanocrystal (FDFN) Fast dissolving film nanocrystal (FDFN) preparation as a new trend for solubility enhancement of poorly soluble class ii drug tenoxicam Furqan M. Abdulelah Mustafa R. Abdulbaqi Medicina poor solubility Tenoxicam (TNX) nanocrystal fast dissolving film nanocrystal (FDFN) Objective: This research targeted to prepare, characterize and evaluate fast dissolving film nanocrystals (FDFN) of tenoxicam (TNX) as an innovative system using three different film-former polymers, HPMC E 30, PVP K90 and PVA, for the optimization of BCS class II drug solubility, dissolution rate and bioavailability. Methods: TNX nanocrystals first prepared using acid-base nanoprecipitation method, which further formulated into fifteen FDF using HPMC E 30, PVP K90 and PVA as film-formers. Films were then evaluated for appearance, surface pH, folding endurance, thickness, weight variation, TS, PE, disintegration time and TNX release durations. Results: TNX nanocrystal were prepared successfully with optimized physical properties including solubility due size reduction. Six formulation, F-1, F-2, F-6, F-8, F-11 and F-12, exhibit desired FDF features as indicated by characterization techniques including fast disintegration in less than 30 seconds and in vitro dissolution within two minutes. Conclusion: Six TNX-FDFN formulations were prepared successfully with ideal film properties and improved TNX solubility and hence, can used as an alternative to the oral form thereby avoiding associated limitations of GI irritation and poor solubility of TNX. 2021 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55971452001 https://www.redalyc.org/journal/559/55971452001/ https://www.redalyc.org/journal/559/55971452001/html/ https://www.redalyc.org/journal/559/55971452001/55971452001.epub https://www.redalyc.org/journal/559/55971452001/movil https://doi.org/10.5281/zenodo.5218600 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.4 Vol.40 |
| title | Fast dissolving film nanocrystal (FDFN) preparation as a new trend for solubility enhancement of poorly soluble class ii drug tenoxicam |
| topic | Medicina poor solubility Tenoxicam (TNX) nanocrystal fast dissolving film nanocrystal (FDFN) |
| url | https://www.redalyc.org/articulo.oa?id=55971452001 https://www.redalyc.org/journal/559/55971452001/ https://www.redalyc.org/journal/559/55971452001/html/ https://www.redalyc.org/journal/559/55971452001/55971452001.epub https://www.redalyc.org/journal/559/55971452001/movil https://doi.org/10.5281/zenodo.5218600 |