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| Natura: | Artículo científico |
| Lingua: | en |
| Pubblicazione: |
Sociedad Venezolana de Farmacología Clínica y Terapéutica
2021
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=55971452014 https://www.redalyc.org/journal/559/55971452014/ https://www.redalyc.org/journal/559/55971452014/html/ https://www.redalyc.org/journal/559/55971452014/55971452014.epub https://www.redalyc.org/journal/559/55971452014/movil https://doi.org/10.5281/zenodo.5227566 |
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| _version_ | 1866814319690252288 |
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| author | Mahmood A. Al Ani |
| author_facet | Mahmood A. Al Ani |
| contents | Use of calcium channel blockers and NSAIDS as alternative to anticholinergics in the treatment of urge urinary incontinence in women Mahmood A. Al Ani Zahraa Al-Tamimi Reem Ali Haddad Nawar Sahib Khalil Medicina NSAIDs anticholinergics Urinary incontinence calcium channel blockers Objectives: The present study aimed to investigate the effect of use of calcium channel blockers and non-steroid anti-inflammatory drugs as alternative to the anticholinergics therapy in cases of urge urinary incontinence in women. Methods: A total of 63 women with urge incontinence were included in the study after inclusion and exclusion criteria and randomized into three treatment groups and their clinical and urodynamic parameters were recorded and analyzed comparatively. Results: Significant differences were found in the means of patients’ urinary incontinence parameters including numbers of voidings and of leakage episodes per day as well as their urodynamic parameters including maximum bladder capacity, volume at 1st contraction and residual volume after using Solifenacine, calcium channel blocker (Nifidipine. or Non-steroid anti-inflammatory (Ponstan) drugs (.<0.05). Furthermore, significant differences were found among study’s groups regarding their response for treatment indicated by improvement in clinical and urodynamic parameters (.<0.05).Conclusion: The study demonstrated that CCBs seem to be having some beneficial effects, with a different adverse effect profile and so may be used to complement a lower dose of anticholinergic drug. 2021 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55971452014 https://www.redalyc.org/journal/559/55971452014/ https://www.redalyc.org/journal/559/55971452014/html/ https://www.redalyc.org/journal/559/55971452014/55971452014.epub https://www.redalyc.org/journal/559/55971452014/movil https://doi.org/10.5281/zenodo.5227566 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.4 Vol.40 |
| format | Artículo científico |
| id | redalyc_55971452014 |
| language | en |
| publishDate | 2021 |
| publisher | Sociedad Venezolana de Farmacología Clínica y Terapéutica |
| spellingShingle | Use of calcium channel blockers and NSAIDS as alternative to anticholinergics in the treatment of urge urinary incontinence in women Mahmood A. Al Ani Medicina NSAIDs anticholinergics Urinary incontinence calcium channel blockers Use of calcium channel blockers and NSAIDS as alternative to anticholinergics in the treatment of urge urinary incontinence in women Mahmood A. Al Ani Zahraa Al-Tamimi Reem Ali Haddad Nawar Sahib Khalil Medicina NSAIDs anticholinergics Urinary incontinence calcium channel blockers Objectives: The present study aimed to investigate the effect of use of calcium channel blockers and non-steroid anti-inflammatory drugs as alternative to the anticholinergics therapy in cases of urge urinary incontinence in women. Methods: A total of 63 women with urge incontinence were included in the study after inclusion and exclusion criteria and randomized into three treatment groups and their clinical and urodynamic parameters were recorded and analyzed comparatively. Results: Significant differences were found in the means of patients’ urinary incontinence parameters including numbers of voidings and of leakage episodes per day as well as their urodynamic parameters including maximum bladder capacity, volume at 1st contraction and residual volume after using Solifenacine, calcium channel blocker (Nifidipine. or Non-steroid anti-inflammatory (Ponstan) drugs (.<0.05). Furthermore, significant differences were found among study’s groups regarding their response for treatment indicated by improvement in clinical and urodynamic parameters (.<0.05).Conclusion: The study demonstrated that CCBs seem to be having some beneficial effects, with a different adverse effect profile and so may be used to complement a lower dose of anticholinergic drug. 2021 artículo científico 0798-0264 https://www.redalyc.org/articulo.oa?id=55971452014 https://www.redalyc.org/journal/559/55971452014/ https://www.redalyc.org/journal/559/55971452014/html/ https://www.redalyc.org/journal/559/55971452014/55971452014.epub https://www.redalyc.org/journal/559/55971452014/movil https://doi.org/10.5281/zenodo.5227566 en http://www.redalyc.org/revista.oa?id=559 Archivos Venezolanos de Farmacología y Terapéutica application/pdf Sociedad Venezolana de Farmacología Clínica y Terapéutica Archivos Venezolanos de Farmacología y Terapéutica (República Bolivariana de Venezuela) Num.4 Vol.40 |
| title | Use of calcium channel blockers and NSAIDS as alternative to anticholinergics in the treatment of urge urinary incontinence in women |
| topic | Medicina NSAIDs anticholinergics Urinary incontinence calcium channel blockers |
| url | https://www.redalyc.org/articulo.oa?id=55971452014 https://www.redalyc.org/journal/559/55971452014/ https://www.redalyc.org/journal/559/55971452014/html/ https://www.redalyc.org/journal/559/55971452014/55971452014.epub https://www.redalyc.org/journal/559/55971452014/movil https://doi.org/10.5281/zenodo.5227566 |