Cranberry dosed extract: an effective therapy for recurrent Escherichia coli cystitis in elderly patients. The GerHogar Cysticlean® study
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| Format: | Artículo científico |
| Language: | en |
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Asociación Colombiana de Nefrología e Hipertensión Arterial
2021
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| author | Juan Florencio Macías Núñez |
| author_facet | Juan Florencio Macías Núñez |
| contents | Cranberry dosed extract: an effective therapy for recurrent Escherichia coli cystitis in elderly patients. The GerHogar Cysticlean® study Juan Florencio Macías Núñez Carmen Pablos Hernández Jesús Cuadrado Blanco Guzmán Tamame Gonzalez Agapito Gómez Villa Amparo del Cañizo Álvarez Carlos Guido Musso Medicina cystitis Cranberry Escherichia coli Infections Introduction: Cystitis is the most prevalent urinary tract infection (UTI), and antibiotics are its conventional therapy. However, the prevalence rate of antibiotic resistance to uropathogens is significantly increased. Cranberry treatment has been associated with the inhibition of Escherichia coli (Ec) adherence to uroepithelial cells due to the anti-adhesive property related to its proanthocyanidins content, and cysticlean® (CYS) is a cranberry extract which contains 240 mg PACs per capsule. Since elderly people is one of the populations mostly exposed to cystitis and bacteria antibiotic resistance, it was decided to originally study the efficacy and safety of CYS, to treat cystitis instead of antibiotic, in elderly individuals.Material & Methods: Two groups were studied: Group 1 (G1): first cystitis episode was recorded within the last 3 months before the study initiation. Group 2 (G2): frequent cystitis recurrent episodes (1-2/month or more) within the last 3 months before the study initiation. G1 patients were treated with 1 capsule of CYS every 12 h for 1 month, while G2 patients were treated up to 12 months. Comparative evaluation was performed using Student test. Results: 160 elderly ambulatory and nursing home patients suffering from recurrent cystitis were treated with CYS. G1 and G2 had 38 and 122 subjects, respectively. Cranberry-based cystitis treatment was successful in 81.57 % and 81.96 % in G1 and G2 patients, respectively.Conclusion: CYS showed to be an effective alternative therapy to antibiotics to treat cystitis recurrences caused by Ec. Neither side effects nor adverse reactions have been reported. 2021 artículo científico 2389-7708 https://www.redalyc.org/articulo.oa?id=560179996006 https://www.redalyc.org/journal/5601/560179996006/ https://www.redalyc.org/journal/5601/560179996006/html/ https://www.redalyc.org/journal/5601/560179996006/560179996006.epub https://www.redalyc.org/journal/5601/560179996006/movil 10.22265/acnef.8.1.545 en http://www.redalyc.org/revista.oa?id=5601 Revista Colombiana de Nefrología application/pdf Asociación Colombiana de Nefrología e Hipertensión Arterial Revista Colombiana de Nefrología (Colombia) Num.1 Vol.8 |
| format | Artículo científico |
| id | redalyc_560179996006 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Asociación Colombiana de Nefrología e Hipertensión Arterial |
| spellingShingle | Cranberry dosed extract: an effective therapy for recurrent Escherichia coli cystitis in elderly patients. The GerHogar Cysticlean® study Juan Florencio Macías Núñez Medicina cystitis Cranberry Escherichia coli Infections Cranberry dosed extract: an effective therapy for recurrent Escherichia coli cystitis in elderly patients. The GerHogar Cysticlean® study Juan Florencio Macías Núñez Carmen Pablos Hernández Jesús Cuadrado Blanco Guzmán Tamame Gonzalez Agapito Gómez Villa Amparo del Cañizo Álvarez Carlos Guido Musso Medicina cystitis Cranberry Escherichia coli Infections Introduction: Cystitis is the most prevalent urinary tract infection (UTI), and antibiotics are its conventional therapy. However, the prevalence rate of antibiotic resistance to uropathogens is significantly increased. Cranberry treatment has been associated with the inhibition of Escherichia coli (Ec) adherence to uroepithelial cells due to the anti-adhesive property related to its proanthocyanidins content, and cysticlean® (CYS) is a cranberry extract which contains 240 mg PACs per capsule. Since elderly people is one of the populations mostly exposed to cystitis and bacteria antibiotic resistance, it was decided to originally study the efficacy and safety of CYS, to treat cystitis instead of antibiotic, in elderly individuals.Material & Methods: Two groups were studied: Group 1 (G1): first cystitis episode was recorded within the last 3 months before the study initiation. Group 2 (G2): frequent cystitis recurrent episodes (1-2/month or more) within the last 3 months before the study initiation. G1 patients were treated with 1 capsule of CYS every 12 h for 1 month, while G2 patients were treated up to 12 months. Comparative evaluation was performed using Student test. Results: 160 elderly ambulatory and nursing home patients suffering from recurrent cystitis were treated with CYS. G1 and G2 had 38 and 122 subjects, respectively. Cranberry-based cystitis treatment was successful in 81.57 % and 81.96 % in G1 and G2 patients, respectively.Conclusion: CYS showed to be an effective alternative therapy to antibiotics to treat cystitis recurrences caused by Ec. Neither side effects nor adverse reactions have been reported. 2021 artículo científico 2389-7708 https://www.redalyc.org/articulo.oa?id=560179996006 https://www.redalyc.org/journal/5601/560179996006/ https://www.redalyc.org/journal/5601/560179996006/html/ https://www.redalyc.org/journal/5601/560179996006/560179996006.epub https://www.redalyc.org/journal/5601/560179996006/movil 10.22265/acnef.8.1.545 en http://www.redalyc.org/revista.oa?id=5601 Revista Colombiana de Nefrología application/pdf Asociación Colombiana de Nefrología e Hipertensión Arterial Revista Colombiana de Nefrología (Colombia) Num.1 Vol.8 |
| title | Cranberry dosed extract: an effective therapy for recurrent Escherichia coli cystitis in elderly patients. The GerHogar Cysticlean® study |
| topic | Medicina cystitis Cranberry Escherichia coli Infections |
| url | https://www.redalyc.org/articulo.oa?id=560179996006 https://www.redalyc.org/journal/5601/560179996006/ https://www.redalyc.org/journal/5601/560179996006/html/ https://www.redalyc.org/journal/5601/560179996006/560179996006.epub https://www.redalyc.org/journal/5601/560179996006/movil |