Factors Associated with the Presence of ExtendedSpectrum Beta-LactamaseProducing Pathogens in Urinary Tract Infections in a Private Clinic in Lima, Peru
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| Format: | Artículo científico |
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Universidad del Rosario
2020
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| author | Vania Remenik-Zarauz |
| author_facet | Vania Remenik-Zarauz |
| contents | Factors Associated with the Presence of ExtendedSpectrum Beta-LactamaseProducing Pathogens in Urinary Tract Infections in a Private Clinic in Lima, Peru Vania Remenik-Zarauz Cristian Diaz-Velez Moisés Apolaya-Segura Salud beta lactamase antibiotic resistance Urinary tract infection Introduction: Urinary tract infections (utis) are the second most frequent reason for healthcare visits, and antibiotic resistance among gram-negative bacteria of the Enterobacteriaceae family has increased significantly worldwide. The emergence of microorganisms that produce extended-spectrum beta-lactamase (esbl) is especially problematic. This study aims to identify factors associated with the presence of uti caused by esbl-producing pathogens. Material and methods: An analytical cross-sectional study was conducted, and the urine culture database from a private healthcare clinic was analyzed. Factors possibly associated with the appearance of utis due to esbl-producing pathogens were analyzed, including sex, age, number of hospitalizations, and previous utis. Results: A total of 1405 positive urine cultures were studied, 85.48% of which belonged to women. The mean age of the subjects was 39.98 ± 24.51 years, 24.13% of whom were over 60 years old. Of these, 55.56% had been attended on an outpatient basis. Almost half (49.18%) of the cultures tested positive for esbl-related uti, 96.58% of which had not presented with a previous uti. A statistically significant association was found between sex and the development of uti caused by esbl-producing microorganisms (p = 0.007), with the male sex having the highest association (prevalence ratio, 1.224; 95% confidence interval: 1.035–1.448). In addition, age, number of previous hospitalizations, and prior intensive care unit admissions also showed associations with uti development. No association was found with the presence of previous utis. Conclusion: A high frequency of utis were esbl-related, and the factors associated with esbl-related utis were male sex, age >60, and previous hospitalizations. 2020 artículo científico 1692-7273 https://www.redalyc.org/articulo.oa?id=56263561003 https://www.redalyc.org/journal/562/56263561003/ https://www.redalyc.org/journal/562/56263561003/html/ https://www.redalyc.org/journal/562/56263561003/56263561003.epub https://www.redalyc.org/journal/562/56263561003/movil https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.9255 en http://www.redalyc.org/revista.oa?id=562 Revista Ciencias de la Salud application/pdf Universidad del Rosario Revista Ciencias de la Salud (Colombia) Num.2 Vol.18 |
| format | Artículo científico |
| id | redalyc_56263561003 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Universidad del Rosario |
| spellingShingle | Factors Associated with the Presence of ExtendedSpectrum Beta-LactamaseProducing Pathogens in Urinary Tract Infections in a Private Clinic in Lima, Peru Vania Remenik-Zarauz Salud beta lactamase antibiotic resistance Urinary tract infection Factors Associated with the Presence of ExtendedSpectrum Beta-LactamaseProducing Pathogens in Urinary Tract Infections in a Private Clinic in Lima, Peru Vania Remenik-Zarauz Cristian Diaz-Velez Moisés Apolaya-Segura Salud beta lactamase antibiotic resistance Urinary tract infection Introduction: Urinary tract infections (utis) are the second most frequent reason for healthcare visits, and antibiotic resistance among gram-negative bacteria of the Enterobacteriaceae family has increased significantly worldwide. The emergence of microorganisms that produce extended-spectrum beta-lactamase (esbl) is especially problematic. This study aims to identify factors associated with the presence of uti caused by esbl-producing pathogens. Material and methods: An analytical cross-sectional study was conducted, and the urine culture database from a private healthcare clinic was analyzed. Factors possibly associated with the appearance of utis due to esbl-producing pathogens were analyzed, including sex, age, number of hospitalizations, and previous utis. Results: A total of 1405 positive urine cultures were studied, 85.48% of which belonged to women. The mean age of the subjects was 39.98 ± 24.51 years, 24.13% of whom were over 60 years old. Of these, 55.56% had been attended on an outpatient basis. Almost half (49.18%) of the cultures tested positive for esbl-related uti, 96.58% of which had not presented with a previous uti. A statistically significant association was found between sex and the development of uti caused by esbl-producing microorganisms (p = 0.007), with the male sex having the highest association (prevalence ratio, 1.224; 95% confidence interval: 1.035–1.448). In addition, age, number of previous hospitalizations, and prior intensive care unit admissions also showed associations with uti development. No association was found with the presence of previous utis. Conclusion: A high frequency of utis were esbl-related, and the factors associated with esbl-related utis were male sex, age >60, and previous hospitalizations. 2020 artículo científico 1692-7273 https://www.redalyc.org/articulo.oa?id=56263561003 https://www.redalyc.org/journal/562/56263561003/ https://www.redalyc.org/journal/562/56263561003/html/ https://www.redalyc.org/journal/562/56263561003/56263561003.epub https://www.redalyc.org/journal/562/56263561003/movil https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.9255 en http://www.redalyc.org/revista.oa?id=562 Revista Ciencias de la Salud application/pdf Universidad del Rosario Revista Ciencias de la Salud (Colombia) Num.2 Vol.18 |
| title | Factors Associated with the Presence of ExtendedSpectrum Beta-LactamaseProducing Pathogens in Urinary Tract Infections in a Private Clinic in Lima, Peru |
| topic | Salud beta lactamase antibiotic resistance Urinary tract infection |
| url | https://www.redalyc.org/articulo.oa?id=56263561003 https://www.redalyc.org/journal/562/56263561003/ https://www.redalyc.org/journal/562/56263561003/html/ https://www.redalyc.org/journal/562/56263561003/56263561003.epub https://www.redalyc.org/journal/562/56263561003/movil https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.9255 |