Evaluation of Differences in Metabolic and Immunologic Markers and Cardiovascular Risk in hiv-1 Patients
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| Format: | Artículo científico |
| Sprache: | en |
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Universidad del Rosario
2021
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| author | Gustavo Castro |
| author_facet | Gustavo Castro |
| contents | Evaluation of Differences in Metabolic and Immunologic Markers and Cardiovascular Risk in hiv-1 Patients Gustavo Castro Kevin León Damariz Marín-Palma Sarita M. Oyuela Jhon Ubeimar Cataño-Bedoya Julieta Duque-Botero Diana Patricia Giraldo-Méndez Natalia A. Taborda Juan C. Hernandez María Teresa Rugeles Fabián Alberto Jaimes Salud Hiv inflammation disease progression cardiovascular diseases Introduction: hiv infection induces an exacerbated chronic inflammatory response, which triggers metabolic disorders and cardiovascular diseases; however, there are individuals, known as hiv controllers, who do not have typical progression markers. As cardiovascular risk tests are not accurate on hiv-1 infected patients, the study of metabolic and inflammatory parameters in individuals with different patterns of progression could contribute to the definition of predictors of cardiovascular disease in this population. The aim of this study was to compare hiv controllers and hiv progressors (with and without antiretroviral therapy) as well as with healthy controls in order to explore differences and correlations in metabolic and inflammatory biomarkers associated with cardiovascular risk. Materials and methods: This was a cross-sectional analytical study which included 63 individuals infected with hiv-1 classified as hiv controllers or progressors (with or without antiretroviral therapy), and a healthy control group. The following parameters were determined: carotid intima-media thickness (cimt); cardiovascular risk scores; lipid profile, fasting glucose, high-sensitivity crp, D-dimer, sCD14, sCD163, il-6, and il-18. Data were compared with Anova or Kruskal–Wallis, and correlations were evaluated by the Spearman coefficient. Results:While there were no significant differences in Framingham, dad or cimt values, hiv controllers exhibited lower triglycerides levels when compared with hiv progressors. No differences were observed in markers, such as high-sensitivity crp, il-6, il-18, and sCD163, among the groups. The median hdl value was higher in hiv progressors on antiretroviral therapy, and cimt in hiv controllers was negatively correlated with sCD14. Conclusion: hiv controllers have a different cardiovascular profile than hiv progressors according to their values in metabolic and immunological biomarkers. 2021 artículo científico 1692-7273 https://www.redalyc.org/articulo.oa?id=56268492003 https://www.redalyc.org/journal/562/56268492003/ https://www.redalyc.org/journal/562/56268492003/html/ https://www.redalyc.org/journal/562/56268492003/56268492003.epub https://www.redalyc.org/journal/562/56268492003/movil https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.10532 en http://www.redalyc.org/revista.oa?id=562 Revista Ciencias de la Salud application/pdf Universidad del Rosario Revista Ciencias de la Salud (Colombia) Num.3 Vol.19 |
| format | Artículo científico |
| id | redalyc_56268492003 |
| institution | Redalyc |
| language | en |
| publishDate | 2021 |
| publisher | Universidad del Rosario |
| spellingShingle | Evaluation of Differences in Metabolic and Immunologic Markers and Cardiovascular Risk in hiv-1 Patients Gustavo Castro Salud Hiv inflammation disease progression cardiovascular diseases Evaluation of Differences in Metabolic and Immunologic Markers and Cardiovascular Risk in hiv-1 Patients Gustavo Castro Kevin León Damariz Marín-Palma Sarita M. Oyuela Jhon Ubeimar Cataño-Bedoya Julieta Duque-Botero Diana Patricia Giraldo-Méndez Natalia A. Taborda Juan C. Hernandez María Teresa Rugeles Fabián Alberto Jaimes Salud Hiv inflammation disease progression cardiovascular diseases Introduction: hiv infection induces an exacerbated chronic inflammatory response, which triggers metabolic disorders and cardiovascular diseases; however, there are individuals, known as hiv controllers, who do not have typical progression markers. As cardiovascular risk tests are not accurate on hiv-1 infected patients, the study of metabolic and inflammatory parameters in individuals with different patterns of progression could contribute to the definition of predictors of cardiovascular disease in this population. The aim of this study was to compare hiv controllers and hiv progressors (with and without antiretroviral therapy) as well as with healthy controls in order to explore differences and correlations in metabolic and inflammatory biomarkers associated with cardiovascular risk. Materials and methods: This was a cross-sectional analytical study which included 63 individuals infected with hiv-1 classified as hiv controllers or progressors (with or without antiretroviral therapy), and a healthy control group. The following parameters were determined: carotid intima-media thickness (cimt); cardiovascular risk scores; lipid profile, fasting glucose, high-sensitivity crp, D-dimer, sCD14, sCD163, il-6, and il-18. Data were compared with Anova or Kruskal–Wallis, and correlations were evaluated by the Spearman coefficient. Results:While there were no significant differences in Framingham, dad or cimt values, hiv controllers exhibited lower triglycerides levels when compared with hiv progressors. No differences were observed in markers, such as high-sensitivity crp, il-6, il-18, and sCD163, among the groups. The median hdl value was higher in hiv progressors on antiretroviral therapy, and cimt in hiv controllers was negatively correlated with sCD14. Conclusion: hiv controllers have a different cardiovascular profile than hiv progressors according to their values in metabolic and immunological biomarkers. 2021 artículo científico 1692-7273 https://www.redalyc.org/articulo.oa?id=56268492003 https://www.redalyc.org/journal/562/56268492003/ https://www.redalyc.org/journal/562/56268492003/html/ https://www.redalyc.org/journal/562/56268492003/56268492003.epub https://www.redalyc.org/journal/562/56268492003/movil https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.10532 en http://www.redalyc.org/revista.oa?id=562 Revista Ciencias de la Salud application/pdf Universidad del Rosario Revista Ciencias de la Salud (Colombia) Num.3 Vol.19 |
| title | Evaluation of Differences in Metabolic and Immunologic Markers and Cardiovascular Risk in hiv-1 Patients |
| topic | Salud Hiv inflammation disease progression cardiovascular diseases |
| url | https://www.redalyc.org/articulo.oa?id=56268492003 https://www.redalyc.org/journal/562/56268492003/ https://www.redalyc.org/journal/562/56268492003/html/ https://www.redalyc.org/journal/562/56268492003/56268492003.epub https://www.redalyc.org/journal/562/56268492003/movil https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.10532 |