Bursting and synchronization in gene regulatory dynamics
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| Format: | Artículo científico |
| Language: | en |
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Sociedad Mexicana de Física A.C.
2012
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| _version_ | 1876477609260351488 |
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| author | E. Hernández-Lemus |
| author_facet | E. Hernández-Lemus |
| contents | Bursting and synchronization in gene regulatory dynamics E. Hernández-Lemus K. Baca López Física, Astronomía y Matemáticas Transcriptional pulses biological synchronization Within the enormous complexity associated with gene regulatory dynamics, recently has been discovered a sudden synchronization phe- nomenon that often occurs within sets of genes (commonly associated with energy and metabolism). This process has been called tran- scriptional bursting. To study to what extent bursting and synchronization occur in cancer-associated gene de-regulation, we applied the tools of spectral time series analysis, detrended fluctuations analysis and information theory to categorize a set of 1191 whole genome gene expression (steady-state) profiles of both primary breast cancer and normal breast tissue. Results are discussed towards molecular signatures associated with disease. 2012 artículo científico 0035-001X https://www.redalyc.org/articulo.oa?id=57030391012 en http://www.redalyc.org/revista.oa?id=570 Revista Mexicana de Física application/pdf Sociedad Mexicana de Física A.C. Revista Mexicana de Física (México) Num.1 Vol.58 |
| format | Artículo científico |
| id | redalyc_57030391012 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Sociedad Mexicana de Física A.C. |
| spellingShingle | Bursting and synchronization in gene regulatory dynamics E. Hernández-Lemus Física, Astronomía y Matemáticas Transcriptional pulses biological synchronization Bursting and synchronization in gene regulatory dynamics E. Hernández-Lemus K. Baca López Física, Astronomía y Matemáticas Transcriptional pulses biological synchronization Within the enormous complexity associated with gene regulatory dynamics, recently has been discovered a sudden synchronization phe- nomenon that often occurs within sets of genes (commonly associated with energy and metabolism). This process has been called tran- scriptional bursting. To study to what extent bursting and synchronization occur in cancer-associated gene de-regulation, we applied the tools of spectral time series analysis, detrended fluctuations analysis and information theory to categorize a set of 1191 whole genome gene expression (steady-state) profiles of both primary breast cancer and normal breast tissue. Results are discussed towards molecular signatures associated with disease. 2012 artículo científico 0035-001X https://www.redalyc.org/articulo.oa?id=57030391012 en http://www.redalyc.org/revista.oa?id=570 Revista Mexicana de Física application/pdf Sociedad Mexicana de Física A.C. Revista Mexicana de Física (México) Num.1 Vol.58 |
| title | Bursting and synchronization in gene regulatory dynamics |
| topic | Física, Astronomía y Matemáticas Transcriptional pulses biological synchronization |
| url | https://www.redalyc.org/articulo.oa?id=57030391012 |