COVID-19 in patients with obesity: clinicopathological features and immunological mechanisms associated with adverse clinical outcomes
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| Format: | Artículo científico |
| Langue: | en |
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Universidade de Santa Cruz do Sul
2020
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| _version_ | 1876438418134663168 |
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| author | Matheus Ricardo Garbim |
| author_facet | Matheus Ricardo Garbim |
| contents | COVID-19 in patients with obesity: clinicopathological features and immunological mechanisms associated with adverse clinical outcomes Matheus Ricardo Garbim Maria Eduarda Ferraz Carolina Panis Salud 19 CoV SARS COVID Obesity Background and objectives: The infection with the new coronavirus (SARS-CoV-2), which causes COVID-19, has been demonstrating to be more severe in patients with risk factors, increasing susceptibility of this patients to mechanical ventilation and mortality, with obesity standing out. The present study reviews the epidemiology of obesity and the possible immunological mechanisms that associate obesity one of the worst clinical scenarios in COVID-19. Methods: This study consists of an exploratory narrativereview. In data collection, were considered among the scientific publications of the studied topic, articles published in English, Spanish and Portuguese languages between June 2015 and June 2020, in the electronic databases, PubMed and Virtual Health Library (BVS). The indexing terms used were: “SARS-CoV-2”, “Obesity”, “COVID-19”, “Risk Factors”. Content: Obesity is a pandemic and its chronic inflammatory condition is a risk factor for several pathologies, including worse outcome in viral respiratory infections. The immunological analysis of this risk factor and its respective role in the immunopathology of SARS-CoV-2, reveals a deregulated pro-inflammatory response, with a marked increase in several cytokines, such as TNF-α, IL-6 and IL-1β. Such mechanisms result in a cytokine storm, with a consequent deterioration of the immune response for the new coronavirus infection that have been linked to the severe form of disease Conclusion: Obesity is a global relevant risk factor for SARS-CoV-2 infection because it disrupts the pro-inflammatory immune response, resulting in a worse clinical outcome, which deserves a special attention from the policies against the pandemia. 2020 artículo científico 2238-3360 https://www.redalyc.org/articulo.oa?id=570469752013 https://www.redalyc.org/journal/5704/570469752013/ https://www.redalyc.org/journal/5704/570469752013/html/ https://www.redalyc.org/journal/5704/570469752013/570469752013.epub https://www.redalyc.org/journal/5704/570469752013/movil https://doi.org/10.17058/reci.v10i4.15459 en http://www.redalyc.org/revista.oa?id=5704 Revista de Epidemiologia e Controle de Infecção application/pdf Universidade de Santa Cruz do Sul Revista de Epidemiologia e Controle de Infecção (Brasil) Num.4 Vol.10 |
| format | Artículo científico |
| id | redalyc_570469752013 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Universidade de Santa Cruz do Sul |
| spellingShingle | COVID-19 in patients with obesity: clinicopathological features and immunological mechanisms associated with adverse clinical outcomes Matheus Ricardo Garbim Salud 19 CoV SARS COVID Obesity COVID-19 in patients with obesity: clinicopathological features and immunological mechanisms associated with adverse clinical outcomes Matheus Ricardo Garbim Maria Eduarda Ferraz Carolina Panis Salud 19 CoV SARS COVID Obesity Background and objectives: The infection with the new coronavirus (SARS-CoV-2), which causes COVID-19, has been demonstrating to be more severe in patients with risk factors, increasing susceptibility of this patients to mechanical ventilation and mortality, with obesity standing out. The present study reviews the epidemiology of obesity and the possible immunological mechanisms that associate obesity one of the worst clinical scenarios in COVID-19. Methods: This study consists of an exploratory narrativereview. In data collection, were considered among the scientific publications of the studied topic, articles published in English, Spanish and Portuguese languages between June 2015 and June 2020, in the electronic databases, PubMed and Virtual Health Library (BVS). The indexing terms used were: “SARS-CoV-2”, “Obesity”, “COVID-19”, “Risk Factors”. Content: Obesity is a pandemic and its chronic inflammatory condition is a risk factor for several pathologies, including worse outcome in viral respiratory infections. The immunological analysis of this risk factor and its respective role in the immunopathology of SARS-CoV-2, reveals a deregulated pro-inflammatory response, with a marked increase in several cytokines, such as TNF-α, IL-6 and IL-1β. Such mechanisms result in a cytokine storm, with a consequent deterioration of the immune response for the new coronavirus infection that have been linked to the severe form of disease Conclusion: Obesity is a global relevant risk factor for SARS-CoV-2 infection because it disrupts the pro-inflammatory immune response, resulting in a worse clinical outcome, which deserves a special attention from the policies against the pandemia. 2020 artículo científico 2238-3360 https://www.redalyc.org/articulo.oa?id=570469752013 https://www.redalyc.org/journal/5704/570469752013/ https://www.redalyc.org/journal/5704/570469752013/html/ https://www.redalyc.org/journal/5704/570469752013/570469752013.epub https://www.redalyc.org/journal/5704/570469752013/movil https://doi.org/10.17058/reci.v10i4.15459 en http://www.redalyc.org/revista.oa?id=5704 Revista de Epidemiologia e Controle de Infecção application/pdf Universidade de Santa Cruz do Sul Revista de Epidemiologia e Controle de Infecção (Brasil) Num.4 Vol.10 |
| title | COVID-19 in patients with obesity: clinicopathological features and immunological mechanisms associated with adverse clinical outcomes |
| topic | Salud 19 CoV SARS COVID Obesity |
| url | https://www.redalyc.org/articulo.oa?id=570469752013 https://www.redalyc.org/journal/5704/570469752013/ https://www.redalyc.org/journal/5704/570469752013/html/ https://www.redalyc.org/journal/5704/570469752013/570469752013.epub https://www.redalyc.org/journal/5704/570469752013/movil https://doi.org/10.17058/reci.v10i4.15459 |