Staphylococcus aureus: changes in antimicrobial sensitivity profile and its relationship with SCCmec among clinical isolates

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Main Author:	Felipe Crepaldi Duarte
Format:	Artículo científico
Language:	en
Published:	Universidade de Santa Cruz do Sul 2024
Subjects:	Salud MRSA MSSA aureus Clinical Epidemiology
Online Access:	Acceder al recurso 1 Acceder al recurso 2 Acceder al recurso 3 Acceder al recurso 4 Acceder al recurso 5 Acceder al recurso 6
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author	Felipe Crepaldi Duarte
author_facet	Felipe Crepaldi Duarte
contents	Staphylococcus aureus: changes in antimicrobial sensitivity profile and its relationship with SCCmec among clinical isolates Felipe Crepaldi Duarte Diogo Cesar Carraro Livia Marina Finger Renan Hayami Obata Sueli Fumie Yamada-Ogatta Philipe Quagliato Bellinati Marcia Regina Eches Perugini Salud MRSA MSSA aureus Clinical Epidemiology Background and Objectives: Staphylococcus aureus is a pathogen of great clinical relevance, especially those resistant to methicillin, called MRSA. Over the years, S. aureus antimicrobial resistance patterns have changed. Understanding such changes is essential to update protocols and propose efficient therapeutic approaches. This study aimed to characterize the temporal distribution of S. aureus antimicrobial resistance in patients admitted to the hospital as well as to assess its relationship with SCCmec typing. Methods: a total of 9,949 cultures of clinical materials were analyzed, between January 2000 and October 2019, from patients admitted to a university hospital in southern Brazil. All isolates had their identification and antimicrobial sensitivity profile analyzed using manual and automated techniques. Furthermore, 86 isolates were selected for mecA gene research and SCCmec typing using conventional and multiplex PCR techniques, respectively. Results: when assessing the temporal distribution of S. aureus over 20 years, it was possible to observe a drop in the proportion of MRSA compared to methicillin-sensitive S. aureus (MSSA). Between 2000 and 2002, the frequency of MRSA was 58.5%, whereas that of MSSA was 36.7%. However, from 2003 onwards, there was a reversal of these percentages. At the end of the analyzed period, 55.2% of infections were caused by MSSA, whereas 36.2% contained MRSA isolates. Furthermore, in the period analyzed, the highest prevalence was of SCCmec type II. Conclusion: these data suggest an epidemiological change in S. aureus from clinical materials, with a change in the prevalent type of SCCmec and changes in the antimicrobial sensitivity profile exhibited by the isolates. Such facts must be considered by the clinical staff with a focus on effective patient management, the choice of appropriate antimicrobial therapy so that effective infection control measures are implemented. 2024 artículo científico 2238-3360 https://www.redalyc.org/articulo.oa?id=570480781007 https://www.redalyc.org/journal/5704/570480781007/ https://www.redalyc.org/journal/5704/570480781007/html/ https://www.redalyc.org/journal/5704/570480781007/570480781007.epub https://www.redalyc.org/journal/5704/570480781007/movil https://doi.org/10.17058/reci.v14i2.18905 en http://www.redalyc.org/revista.oa?id=5704 Revista de Epidemiologia e Controle de Infecção application/pdf Universidade de Santa Cruz do Sul Revista de Epidemiologia e Controle de Infecção (Brasil) Num.2 Vol.14
format	Artículo científico
id	redalyc_570480781007
institution	Redalyc
language	en
publishDate	2024
publisher	Universidade de Santa Cruz do Sul
spellingShingle	Staphylococcus aureus: changes in antimicrobial sensitivity profile and its relationship with SCCmec among clinical isolates Felipe Crepaldi Duarte Salud MRSA MSSA aureus Clinical Epidemiology Staphylococcus aureus: changes in antimicrobial sensitivity profile and its relationship with SCCmec among clinical isolates Felipe Crepaldi Duarte Diogo Cesar Carraro Livia Marina Finger Renan Hayami Obata Sueli Fumie Yamada-Ogatta Philipe Quagliato Bellinati Marcia Regina Eches Perugini Salud MRSA MSSA aureus Clinical Epidemiology Background and Objectives: Staphylococcus aureus is a pathogen of great clinical relevance, especially those resistant to methicillin, called MRSA. Over the years, S. aureus antimicrobial resistance patterns have changed. Understanding such changes is essential to update protocols and propose efficient therapeutic approaches. This study aimed to characterize the temporal distribution of S. aureus antimicrobial resistance in patients admitted to the hospital as well as to assess its relationship with SCCmec typing. Methods: a total of 9,949 cultures of clinical materials were analyzed, between January 2000 and October 2019, from patients admitted to a university hospital in southern Brazil. All isolates had their identification and antimicrobial sensitivity profile analyzed using manual and automated techniques. Furthermore, 86 isolates were selected for mecA gene research and SCCmec typing using conventional and multiplex PCR techniques, respectively. Results: when assessing the temporal distribution of S. aureus over 20 years, it was possible to observe a drop in the proportion of MRSA compared to methicillin-sensitive S. aureus (MSSA). Between 2000 and 2002, the frequency of MRSA was 58.5%, whereas that of MSSA was 36.7%. However, from 2003 onwards, there was a reversal of these percentages. At the end of the analyzed period, 55.2% of infections were caused by MSSA, whereas 36.2% contained MRSA isolates. Furthermore, in the period analyzed, the highest prevalence was of SCCmec type II. Conclusion: these data suggest an epidemiological change in S. aureus from clinical materials, with a change in the prevalent type of SCCmec and changes in the antimicrobial sensitivity profile exhibited by the isolates. Such facts must be considered by the clinical staff with a focus on effective patient management, the choice of appropriate antimicrobial therapy so that effective infection control measures are implemented. 2024 artículo científico 2238-3360 https://www.redalyc.org/articulo.oa?id=570480781007 https://www.redalyc.org/journal/5704/570480781007/ https://www.redalyc.org/journal/5704/570480781007/html/ https://www.redalyc.org/journal/5704/570480781007/570480781007.epub https://www.redalyc.org/journal/5704/570480781007/movil https://doi.org/10.17058/reci.v14i2.18905 en http://www.redalyc.org/revista.oa?id=5704 Revista de Epidemiologia e Controle de Infecção application/pdf Universidade de Santa Cruz do Sul Revista de Epidemiologia e Controle de Infecção (Brasil) Num.2 Vol.14
title	Staphylococcus aureus: changes in antimicrobial sensitivity profile and its relationship with SCCmec among clinical isolates
topic	Salud MRSA MSSA aureus Clinical Epidemiology
url	https://www.redalyc.org/articulo.oa?id=570480781007 https://www.redalyc.org/journal/5704/570480781007/ https://www.redalyc.org/journal/5704/570480781007/html/ https://www.redalyc.org/journal/5704/570480781007/570480781007.epub https://www.redalyc.org/journal/5704/570480781007/movil https://doi.org/10.17058/reci.v14i2.18905