Spindle cell carcinoma of the maxillary sinus with extension to the oral cavity
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| Formato: | Artículo científico |
| Lenguaje: | en |
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Hospital Universitário da Universidade de São Paulo
2020
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| _version_ | 1876469181814145024 |
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| author | Alejandro Donohue-Cornejo |
| author_facet | Alejandro Donohue-Cornejo |
| contents | Spindle cell carcinoma of the maxillary sinus with extension to the oral cavity Alejandro Donohue-Cornejo Oslei Paes de Almeida Celeste Sánchez-Romero Ronell Bologna-Molina León Francisco Espinosa-Cristóbal Juan Carlos Cuevas González Medicina Mouth Carcinoma Diagnosis Spindle cell carcinoma (SCC) is a rare variant of squamous cell carcinoma characterized by elongated and pleomorphic epithelial cells that resemble a sarcoma. Due to its rareness, and histological resemblance to various sarcomas, the diagnosis of this neoplasia is challenging. Herein we present the case of an 82-year-old female with a polypoid, ulcerated, soft tissue mass located on the left side of the maxilla. The tomographic examination showed a hyperdense mass that infiltrated the orbital cavity, ethmoidal cells, middle and lower nasal concha, maxillary sinus, zygomatic arch, and mandibular ramus on the left side. Histopathologically, the tumor was composed of spindle cells that were sarcomatous in appearance, with aberrant mitosis, along with a group of pleomorphic cells with a more epithelioid and hyperchromatic appearance on a stroma of densely vascularized fibrous tissue. The immunohistochemistry panel used to determine the lineage of the tumor rendered the diagnosis of SCC. The diagnosis of SCC is challenging to the pathologist since its morphology can resemble a sarcoma. Thus, immunohistochemistry is a valuable resource to support the diagnosis. We propose that SCC should be considered when examining a biphasic neoplasm with the aforementioned histological characteristics and markers. 2020 otro 2236-1960 https://www.redalyc.org/articulo.oa?id=576065838005 https://www.redalyc.org/journal/5760/576065838005/ https://www.redalyc.org/journal/5760/576065838005/html/ https://www.redalyc.org/journal/5760/576065838005/576065838005.epub https://www.redalyc.org/journal/5760/576065838005/movil 10.4322/acr.2020.161 en http://www.redalyc.org/revista.oa?id=5760 Autopsy and Case Reports application/pdf Hospital Universitário da Universidade de São Paulo Autopsy and Case Reports (Brasil) Num.3 Vol.10 |
| format | Artículo científico |
| id | redalyc_576065838005 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Hospital Universitário da Universidade de São Paulo |
| spellingShingle | Spindle cell carcinoma of the maxillary sinus with extension to the oral cavity Alejandro Donohue-Cornejo Medicina Mouth Carcinoma Diagnosis Spindle cell carcinoma of the maxillary sinus with extension to the oral cavity Alejandro Donohue-Cornejo Oslei Paes de Almeida Celeste Sánchez-Romero Ronell Bologna-Molina León Francisco Espinosa-Cristóbal Juan Carlos Cuevas González Medicina Mouth Carcinoma Diagnosis Spindle cell carcinoma (SCC) is a rare variant of squamous cell carcinoma characterized by elongated and pleomorphic epithelial cells that resemble a sarcoma. Due to its rareness, and histological resemblance to various sarcomas, the diagnosis of this neoplasia is challenging. Herein we present the case of an 82-year-old female with a polypoid, ulcerated, soft tissue mass located on the left side of the maxilla. The tomographic examination showed a hyperdense mass that infiltrated the orbital cavity, ethmoidal cells, middle and lower nasal concha, maxillary sinus, zygomatic arch, and mandibular ramus on the left side. Histopathologically, the tumor was composed of spindle cells that were sarcomatous in appearance, with aberrant mitosis, along with a group of pleomorphic cells with a more epithelioid and hyperchromatic appearance on a stroma of densely vascularized fibrous tissue. The immunohistochemistry panel used to determine the lineage of the tumor rendered the diagnosis of SCC. The diagnosis of SCC is challenging to the pathologist since its morphology can resemble a sarcoma. Thus, immunohistochemistry is a valuable resource to support the diagnosis. We propose that SCC should be considered when examining a biphasic neoplasm with the aforementioned histological characteristics and markers. 2020 otro 2236-1960 https://www.redalyc.org/articulo.oa?id=576065838005 https://www.redalyc.org/journal/5760/576065838005/ https://www.redalyc.org/journal/5760/576065838005/html/ https://www.redalyc.org/journal/5760/576065838005/576065838005.epub https://www.redalyc.org/journal/5760/576065838005/movil 10.4322/acr.2020.161 en http://www.redalyc.org/revista.oa?id=5760 Autopsy and Case Reports application/pdf Hospital Universitário da Universidade de São Paulo Autopsy and Case Reports (Brasil) Num.3 Vol.10 |
| title | Spindle cell carcinoma of the maxillary sinus with extension to the oral cavity |
| topic | Medicina Mouth Carcinoma Diagnosis |
| url | https://www.redalyc.org/articulo.oa?id=576065838005 https://www.redalyc.org/journal/5760/576065838005/ https://www.redalyc.org/journal/5760/576065838005/html/ https://www.redalyc.org/journal/5760/576065838005/576065838005.epub https://www.redalyc.org/journal/5760/576065838005/movil |