Dystrophic muscle distribution in late-stage muscular dystrophy
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| Format: | Artículo científico |
| Language: | en |
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Hospital Universitário da Universidade de São Paulo
2020
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| author | Celeste Michelle Pilato |
| author_facet | Celeste Michelle Pilato |
| contents | Dystrophic muscle distribution in late-stage muscular dystrophy Celeste Michelle Pilato Melissa Sue Walker Andrea M. Nguyen McKay Elizabeth Hanna Scott Lanxing Huang Erika Morgan Lutins M. Alex Meredith Peter Jacob Haar Mathula Thangarajh Hope Theresa Richard Woon Nam Chow Medicina Limb Girdle Cadaver Muscular Dystrophy Muscular Dystrophies There is scant information about the comprehensive distribution of dystrophic muscles in muscular dystrophy. Despite different clinical presentations of muscular dystrophy, a recent multi-center study concluded that phenotypic distribution of dystrophic muscles is independent of clinical phenotype and suggested that there is a common pattern of involved muscles. To evaluate this possibility, the present case report used cadaveric dissection to determine the whole-body distribution of fat-infiltrated, dystrophic muscles from a 72-year-old white male cadaver with adult-onset, late-stage muscular dystrophy. Severely dystrophic muscles occupied the pectoral, gluteal and pelvic regions, as well as the arm, thigh and posterior leg. In contrast, muscles of the head, neck, hands and feet largely appeared unaffected. Histopathology and a CT-scan supported these observations. This pattern of dystrophic muscles generally conformed with that described in the multi-center study, and provides prognostic insight for patients and the physicians treating them. 2020 otro 2236-1960 https://www.redalyc.org/articulo.oa?id=576065839021 https://www.redalyc.org/journal/5760/576065839021/ https://www.redalyc.org/journal/5760/576065839021/html/ https://www.redalyc.org/journal/5760/576065839021/576065839021.epub https://www.redalyc.org/journal/5760/576065839021/movil 10.4322/acr.2020.221 en http://www.redalyc.org/revista.oa?id=5760 Autopsy and Case Reports application/pdf Hospital Universitário da Universidade de São Paulo Autopsy and Case Reports (Brasil) Num.4 Vol.10 |
| format | Artículo científico |
| id | redalyc_576065839021 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Hospital Universitário da Universidade de São Paulo |
| spellingShingle | Dystrophic muscle distribution in late-stage muscular dystrophy Celeste Michelle Pilato Medicina Limb Girdle Cadaver Muscular Dystrophy Muscular Dystrophies Dystrophic muscle distribution in late-stage muscular dystrophy Celeste Michelle Pilato Melissa Sue Walker Andrea M. Nguyen McKay Elizabeth Hanna Scott Lanxing Huang Erika Morgan Lutins M. Alex Meredith Peter Jacob Haar Mathula Thangarajh Hope Theresa Richard Woon Nam Chow Medicina Limb Girdle Cadaver Muscular Dystrophy Muscular Dystrophies There is scant information about the comprehensive distribution of dystrophic muscles in muscular dystrophy. Despite different clinical presentations of muscular dystrophy, a recent multi-center study concluded that phenotypic distribution of dystrophic muscles is independent of clinical phenotype and suggested that there is a common pattern of involved muscles. To evaluate this possibility, the present case report used cadaveric dissection to determine the whole-body distribution of fat-infiltrated, dystrophic muscles from a 72-year-old white male cadaver with adult-onset, late-stage muscular dystrophy. Severely dystrophic muscles occupied the pectoral, gluteal and pelvic regions, as well as the arm, thigh and posterior leg. In contrast, muscles of the head, neck, hands and feet largely appeared unaffected. Histopathology and a CT-scan supported these observations. This pattern of dystrophic muscles generally conformed with that described in the multi-center study, and provides prognostic insight for patients and the physicians treating them. 2020 otro 2236-1960 https://www.redalyc.org/articulo.oa?id=576065839021 https://www.redalyc.org/journal/5760/576065839021/ https://www.redalyc.org/journal/5760/576065839021/html/ https://www.redalyc.org/journal/5760/576065839021/576065839021.epub https://www.redalyc.org/journal/5760/576065839021/movil 10.4322/acr.2020.221 en http://www.redalyc.org/revista.oa?id=5760 Autopsy and Case Reports application/pdf Hospital Universitário da Universidade de São Paulo Autopsy and Case Reports (Brasil) Num.4 Vol.10 |
| title | Dystrophic muscle distribution in late-stage muscular dystrophy |
| topic | Medicina Limb Girdle Cadaver Muscular Dystrophy Muscular Dystrophies |
| url | https://www.redalyc.org/articulo.oa?id=576065839021 https://www.redalyc.org/journal/5760/576065839021/ https://www.redalyc.org/journal/5760/576065839021/html/ https://www.redalyc.org/journal/5760/576065839021/576065839021.epub https://www.redalyc.org/journal/5760/576065839021/movil |