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| Natura: | Artículo científico |
| Lingua: | en |
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Hospital Universitário da Universidade de São Paulo
2022
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| Accesso online: | https://www.redalyc.org/articulo.oa?id=576069818026 https://www.redalyc.org/journal/5760/576069818026/ https://www.redalyc.org/journal/5760/576069818026/html/ https://www.redalyc.org/journal/5760/576069818026/576069818026.epub https://www.redalyc.org/journal/5760/576069818026/movil |
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Sommario:
- Hypoxic hepatitis as a complication of newly diagnosed type 1 diabetes in a teenager Kamil Buczkowski Irena Ożóg-Zabolska Jacek Gulczyński Ewa Iżycka-Świeszewska Medicina Autopsy Hepatitis Pediatrics Gastroenterology Diabetes Mellitus Hypoxic hepatitis is a rare complication of type 1 diabetes with unknown prevalence in Pediatrics. We present a case report of an 11-year-old boy admitted to the ER in the spring of 2020 (the beginning of the COVID19 pandemic in Poland) due to nausea, abdominal pain, and weight loss. A diagnosis of type 1 diabetes accompanied by severe ketoacidosis (pH 6.9, blood glucose 632mg/dl, ketone bodies in urine – 150mg/dl) was made. The hyperglycemia, ketoacidosis, and water-electrolyte disturbances were treated in the Pediatric Intensive Care Unit. On day 4, the boy developed fulminant septic shock with high aminotransferases (AST 9026 U/l, ALT 3559 U/l). CT scan revealed hepatic enlargement and steatosis. Acute viral hepatitis was suspected. The levels of anti-CMV IgM and IgG antibodies were slightly elevated. At autopsy, the liver was enlarged, with petechial bleedings on the surface. The liver parenchyma was congested, with signs of steatosis. Microscopically, there was extensive centrilobular necrosis, acute passive sinusoidal congestion, and steatosis of hepatocytes. There were no signs of CMV infection. Based on the entire clinicopathological picture, the patient was diagnosed with hypoxic hepatitis, complicated by septic shock and multiple organ failure. 2022 artículo científico 2236-1960 https://www.redalyc.org/articulo.oa?id=576069818026 https://www.redalyc.org/journal/5760/576069818026/ https://www.redalyc.org/journal/5760/576069818026/html/ https://www.redalyc.org/journal/5760/576069818026/576069818026.epub https://www.redalyc.org/journal/5760/576069818026/movil 10.4322/acr.2021.372 en http://www.redalyc.org/revista.oa?id=5760 Autopsy and Case Reports application/pdf Hospital Universitário da Universidade de São Paulo Autopsy and Case Reports (Brasil) Vol.12