Sudden pediatric death unveiling pulmonary arteriovenous malformations
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| Format: | Artículo científico |
| Langue: | en |
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Hospital Universitário da Universidade de São Paulo
2024
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| _version_ | 1876485316373643264 |
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| author | Hadeel Abu-El-Rub |
| author_facet | Hadeel Abu-El-Rub |
| contents | Sudden pediatric death unveiling pulmonary arteriovenous malformations Hadeel Abu-El-Rub Rashed Shatnawi Yahia I AbuZetun Doaa Ghorab Ali M. Shotar Medicina Autopsy Sudden Death Forensic Pathology Arteriovenous Malformations Pulmonary arteriovenous malformations (PAVMs) are abnormal vascular connections between pulmonary arteries and veins, often associated with hereditary hemorrhagic telangiectasia (HHT). Most PAVMs are asymptomatic, but life-threatening complications like pulmonary hemorrhage, brain abscesses, and paradoxical emboli can emerge, so prompt diagnosis and treatment are crucial. We report a case of sudden pediatric death in a two-year-old female with no past medical history. Initial vomiting and fast deterioration resulted in a sudden cardiac arrest. The postmortem examination found histological evidence of consistent, extensive lung damage. The absence of the characteristic symptoms made for some challenges when it came to diagnosis, showing precisely that in early life, you could well have many difficulties in catching PAVMs. This case highlights the need to take PAVMs into account as a potential cause of sudden death, particularly when there are no conspicuous symptoms. Awareness among forensic pathologists and consideration of genetic analysis for HHT in such cases is crucial for accurate diagnosis and management. 2024 otro 2236-1960 https://www.redalyc.org/articulo.oa?id=576077572021 https://www.redalyc.org/journal/5760/576077572021/ https://www.redalyc.org/journal/5760/576077572021/html/ https://www.redalyc.org/journal/5760/576077572021/576077572021.epub https://www.redalyc.org/journal/5760/576077572021/movil 10.4322/acr.2024.489 en http://www.redalyc.org/revista.oa?id=5760 Autopsy and Case Reports application/pdf Hospital Universitário da Universidade de São Paulo Autopsy and Case Reports (Brasil) Vol.14 |
| format | Artículo científico |
| id | redalyc_576077572021 |
| institution | Redalyc |
| language | en |
| publishDate | 2024 |
| publisher | Hospital Universitário da Universidade de São Paulo |
| spellingShingle | Sudden pediatric death unveiling pulmonary arteriovenous malformations Hadeel Abu-El-Rub Medicina Autopsy Sudden Death Forensic Pathology Arteriovenous Malformations Sudden pediatric death unveiling pulmonary arteriovenous malformations Hadeel Abu-El-Rub Rashed Shatnawi Yahia I AbuZetun Doaa Ghorab Ali M. Shotar Medicina Autopsy Sudden Death Forensic Pathology Arteriovenous Malformations Pulmonary arteriovenous malformations (PAVMs) are abnormal vascular connections between pulmonary arteries and veins, often associated with hereditary hemorrhagic telangiectasia (HHT). Most PAVMs are asymptomatic, but life-threatening complications like pulmonary hemorrhage, brain abscesses, and paradoxical emboli can emerge, so prompt diagnosis and treatment are crucial. We report a case of sudden pediatric death in a two-year-old female with no past medical history. Initial vomiting and fast deterioration resulted in a sudden cardiac arrest. The postmortem examination found histological evidence of consistent, extensive lung damage. The absence of the characteristic symptoms made for some challenges when it came to diagnosis, showing precisely that in early life, you could well have many difficulties in catching PAVMs. This case highlights the need to take PAVMs into account as a potential cause of sudden death, particularly when there are no conspicuous symptoms. Awareness among forensic pathologists and consideration of genetic analysis for HHT in such cases is crucial for accurate diagnosis and management. 2024 otro 2236-1960 https://www.redalyc.org/articulo.oa?id=576077572021 https://www.redalyc.org/journal/5760/576077572021/ https://www.redalyc.org/journal/5760/576077572021/html/ https://www.redalyc.org/journal/5760/576077572021/576077572021.epub https://www.redalyc.org/journal/5760/576077572021/movil 10.4322/acr.2024.489 en http://www.redalyc.org/revista.oa?id=5760 Autopsy and Case Reports application/pdf Hospital Universitário da Universidade de São Paulo Autopsy and Case Reports (Brasil) Vol.14 |
| title | Sudden pediatric death unveiling pulmonary arteriovenous malformations |
| topic | Medicina Autopsy Sudden Death Forensic Pathology Arteriovenous Malformations |
| url | https://www.redalyc.org/articulo.oa?id=576077572021 https://www.redalyc.org/journal/5760/576077572021/ https://www.redalyc.org/journal/5760/576077572021/html/ https://www.redalyc.org/journal/5760/576077572021/576077572021.epub https://www.redalyc.org/journal/5760/576077572021/movil |