Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice
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| Format: | Artículo científico |
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Asociación Mexicana de Bioquímica Clínica, A.C.
2009
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| author | Fred A. López-Durán |
| author_facet | Fred A. López-Durán |
| contents | Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice Fred A. López-Durán Martha Pedraza-López Consuelo Arteaga de Murphy Edith Hernández-Hernández Rocío García-Becerra David Ordaz-Rosado Medicina angiogenesis Integrin av b3 molecular imaging The multistep process of angiogenesis offers several targets for therapeutic interventions. One molecular target structure is the alfa five beta three (av b3 ) integrin which is expressed on vascular endothelial cells and over-expressed in cancer tumor angiogenesis. To image neoangiogenesis in athymic mice with induced pancreatic, breast and prostate malignant tumors a new radiopharmaceutical was developed. The 99mTc-EDDA/HYNIC-cyclic-Arg-Gly-Asp-D-Phe-Lys (99mTc-cRGD) targets integrin receptors av b3 and was prepared with an average radiochemical purity > 95 %. 99mTc-cRGD shows high in vivo stability, fast blood clearance and rapid renal excretion in mice. There are statistical differences between tumor/muscle ratios for the 3 tumors studied. The highest tumor/non-target ratio was found in breast cancer (7.2 after 24 h) and a representative dorsal SPECT image was obtained where the tumor showed up very clearly over the background tissue. The high resolution of the image implies that 99mTc-cRGD will be of great value in nuclear medicine as a potential radiopharmaceutical for av b3 integrins receptor uptake and for imaging neoangiogenesis in neoplastic tissue and to follow up cancer tumor progression. 2009 artículo científico 0185-5751 https://www.redalyc.org/articulo.oa?id=57612011002 en http://www.redalyc.org/revista.oa?id=576 Bioquimia application/pdf Asociación Mexicana de Bioquímica Clínica, A.C. Bioquimia (México) Num.2 Vol.34 |
| format | Artículo científico |
| id | redalyc_57612011002 |
| institution | Redalyc |
| language | en |
| publishDate | 2009 |
| publisher | Asociación Mexicana de Bioquímica Clínica, A.C. |
| spellingShingle | Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice Fred A. López-Durán Medicina angiogenesis Integrin av b3 molecular imaging Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice Fred A. López-Durán Martha Pedraza-López Consuelo Arteaga de Murphy Edith Hernández-Hernández Rocío García-Becerra David Ordaz-Rosado Medicina angiogenesis Integrin av b3 molecular imaging The multistep process of angiogenesis offers several targets for therapeutic interventions. One molecular target structure is the alfa five beta three (av b3 ) integrin which is expressed on vascular endothelial cells and over-expressed in cancer tumor angiogenesis. To image neoangiogenesis in athymic mice with induced pancreatic, breast and prostate malignant tumors a new radiopharmaceutical was developed. The 99mTc-EDDA/HYNIC-cyclic-Arg-Gly-Asp-D-Phe-Lys (99mTc-cRGD) targets integrin receptors av b3 and was prepared with an average radiochemical purity > 95 %. 99mTc-cRGD shows high in vivo stability, fast blood clearance and rapid renal excretion in mice. There are statistical differences between tumor/muscle ratios for the 3 tumors studied. The highest tumor/non-target ratio was found in breast cancer (7.2 after 24 h) and a representative dorsal SPECT image was obtained where the tumor showed up very clearly over the background tissue. The high resolution of the image implies that 99mTc-cRGD will be of great value in nuclear medicine as a potential radiopharmaceutical for av b3 integrins receptor uptake and for imaging neoangiogenesis in neoplastic tissue and to follow up cancer tumor progression. 2009 artículo científico 0185-5751 https://www.redalyc.org/articulo.oa?id=57612011002 en http://www.redalyc.org/revista.oa?id=576 Bioquimia application/pdf Asociación Mexicana de Bioquímica Clínica, A.C. Bioquimia (México) Num.2 Vol.34 |
| title | Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice |
| topic | Medicina angiogenesis Integrin av b3 molecular imaging |
| url | https://www.redalyc.org/articulo.oa?id=57612011002 |