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Bibliographic Details
Main Author:	Amarilys Torres Domínguez
Format:	Artículo científico
Language:	es
Published:	Asociación Mexicana de Bioquímica Clínica, A.C. 2005
Subjects:	Medicina hemólisis eritrocitos drepanocitemia alquilgliceroles RMN
Online Access:	https://www.redalyc.org/articulo.oa?id=57630402
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Efecto in vitro de los 1-O-alquilgliceroles sintéticos en la falciformación y en la hemólisis de los eritrocitos SS Amarilys Torres Domínguez Francisco Merchán Grisel del Toro García Yolanda C. Valdés Rodríguez José Luis León Medicina hemólisis eritrocitos drepanocitemia alquilgliceroles RMN La drepanocitemia es una enfermedad hereditaria que seexpresa mediante la sustitución de ácido glutámico por valinaen la posición seis en las cadenas-β de la hemoglobinaoriginando la hemoglobina S (HbS). Los 1-O-alquilglicerolesson precursores biosintéticos o catabolitos de los 1-O alquilglicerofosfolípidosde las membranas celulares. En estudiosprevios de los 1-O-alquilgliceroles naturales y sintéticosse encontró que inhiben la actividad de la fosfolipasa 2,Ca2+-ATPasa y Na+ K+-ATPasa de la membrana de eritrocitoshumanos, relacionados con las propiedades surfactantesde estos compuestos, los cuales son responsables de los efectossobre la transformación equinogénica de la membranaeritrocitaria. En este trabajo se analiza mediante microscopíaóptica y resonancia magnética nuclear la acción de los1-O-alquilgliceroles sintéticos C10 y C12 sobre eritrocitosde pacientes con drepanocitemia. Además, se evaluó la actividadhemolítica de los compuestos sobre eritrocitos SS ynormales. Las microfotografías evidenciaron que estos compuestos,a las relaciones molares 1:1 y 1:5, inhibieron latransformación drepanocitaria de los eritrocitos homocigotospara hemoglobina S, favoreciendo la transformaciónequinogénica, aunque el mecanismo implicado en este efectono está relacionado con la inhibición de la polimerizaciónde la hemoglobina S. No hubo diferencia significativa en elporcentaje de hemólisis entre los eritrocitos con HbAA y losde HbSS. Se concluye que los 1-O-alquilgliceroles de C10 yC12 inhiben la falciformación de los eritrocitos SS, posiblementepor interacción de los mismos con la membrana delos eritrocitos. 2005 artículo científico 0185-5751 https://www.redalyc.org/articulo.oa?id=57630402 es http://www.redalyc.org/revista.oa?id=576 Bioquimia application/pdf Asociación Mexicana de Bioquímica Clínica, A.C. Bioquimia (México) Num.4 Vol.30

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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