Dengue disease diagnosis: A puzzle to be solved
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad Nacional de Colombia
2014
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| _version_ | 1876461992022114304 |
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| author | Jaime Eduardo Castellanos |
| author_facet | Jaime Eduardo Castellanos |
| contents | Dengue disease diagnosis: A puzzle to be solved Jaime Eduardo Castellanos Carolina Coronel-Ruiz Medicina Dengue Serology Diagnosis Flavivirus Surveillance (MeSH) Dengue is an infection caused by dengue virus and is the most important arthropod transmitted viral disease in the world, causing near 100 million cases and 50 000 fatalities each year. Health authorities believe that these numbers will grow in coming years. In Colombia, almost 600 municipalities are in regions with Aedes aegypti circulation, and the presence of four dengue serotypes has been demonstrated. Despite the increasing knowledge about disease pathogenesis and the dengue virus, some technical or scientific difficulties with diagnosing dengue remain, negatively affecting both public health surveillance and the appropriate attention to patients in health settings and hospitals. This paper reviews the principles and developments of the current diagnostic techniques for dengue, pointing out the difficulties with making accurate dengue diagnoses and case confirmations in public health and specialized laboratories. The principles and limitations of MAC-ELISA, IgG serology, viral NS1 detection and viral isolation by cell culture are presented. In addition, the review of immunochromatography techniques (rapid diagnostic tests) that have been put forward to help the point-of-care diagnosis is proposed. This paper is intended to bring forward some points of view about the issues related to dengue diagnosis and contribute to improve the discussion surrounding the strategies and techniques needed for reducing the impact of the disease and favoring its control. 2014 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576363531014 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.4 Vol.62 |
| format | Artículo científico |
| id | redalyc_576363531014 |
| institution | Redalyc |
| language | en |
| publishDate | 2014 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Dengue disease diagnosis: A puzzle to be solved Jaime Eduardo Castellanos Medicina Dengue Serology Diagnosis Flavivirus Surveillance (MeSH) Dengue disease diagnosis: A puzzle to be solved Jaime Eduardo Castellanos Carolina Coronel-Ruiz Medicina Dengue Serology Diagnosis Flavivirus Surveillance (MeSH) Dengue is an infection caused by dengue virus and is the most important arthropod transmitted viral disease in the world, causing near 100 million cases and 50 000 fatalities each year. Health authorities believe that these numbers will grow in coming years. In Colombia, almost 600 municipalities are in regions with Aedes aegypti circulation, and the presence of four dengue serotypes has been demonstrated. Despite the increasing knowledge about disease pathogenesis and the dengue virus, some technical or scientific difficulties with diagnosing dengue remain, negatively affecting both public health surveillance and the appropriate attention to patients in health settings and hospitals. This paper reviews the principles and developments of the current diagnostic techniques for dengue, pointing out the difficulties with making accurate dengue diagnoses and case confirmations in public health and specialized laboratories. The principles and limitations of MAC-ELISA, IgG serology, viral NS1 detection and viral isolation by cell culture are presented. In addition, the review of immunochromatography techniques (rapid diagnostic tests) that have been put forward to help the point-of-care diagnosis is proposed. This paper is intended to bring forward some points of view about the issues related to dengue diagnosis and contribute to improve the discussion surrounding the strategies and techniques needed for reducing the impact of the disease and favoring its control. 2014 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576363531014 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.4 Vol.62 |
| title | Dengue disease diagnosis: A puzzle to be solved |
| topic | Medicina Dengue Serology Diagnosis Flavivirus Surveillance (MeSH) |
| url | https://www.redalyc.org/articulo.oa?id=576363531014 |