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Autore principale:	Alba Fernanda Ruíz-Mejía
Natura:	Artículo científico
Lingua:	es
Pubblicazione:	Universidad Nacional de Colombia 2012
Soggetti:	Medicina Pubertad hipotálamo fenómenos metabólicos receptores LHRH (GnRH) (DeCS)
Accesso online:	https://www.redalyc.org/articulo.oa?id=576363538003
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CONCEPTOS ACTUALES SOBRE MECANISMOS REGULADORES DE LA PUBERTAD Alba Fernanda Ruíz-Mejía Ismena Mockus-Sivickas Medicina Pubertad hipotálamo fenómenos metabólicos receptores LHRH (GnRH) (DeCS) El inicio de la pubertad depende de la activación del eje hipotálamo-hipofisiario-gonadal. Existe una red glial y neuronal que interactúa por medio de moléculas de adhesión, factores de crecimiento, aminoácidos, péptidos y derivados lipídicos, que permiten integrar en el hipotálamo la información del estado metabólico del individuo con la que proviene del medio ambiente determinando el comienzo y mantenimiento de la etapa reproductiva. En los últimos años se ha ampliado la comprensión de los factores que intervienen en la pubertad, aunque no se han dilucido todos los mecanismos participantes. Este artículo revisa algunos de los procesos celulares y moleculares más importantes en la regulación de la secreción pulsátil de GnRH, con mayor énfasis en los conocimientos más recientes. 2012 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576363538003 es http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.1 Vol.60

if (filemtime($filename) + $maxlifetime < time()) { unlink($filename); $count++; } } return $count; } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ protected function saveSession($sessId, $data): bool { $sessFile = $this->path . '/sess_' . $sessId; if ($handle = fopen($sessFile, 'w')) { $return = false; // Lock the file for exclusive access to avoid issues with multiple // processes writing session simultaneously: if (flock($handle, LOCK_EX)) { $return = fwrite($handle, $data); // Make sure that there's no trailing data by truncating the file to // the correct length: ftruncate($handle, strlen($data)); fflush($handle); flock($handle, LOCK_UN); } fclose($handle); if ($return !== false) { return true; } } // If we got this far, something went wrong with the file output... // It is tempting to throw an exception here, but this code is called // outside of the context of exception handling, so all we can do is // echo a message.

// Anecdotal testing Today and Yesterday seems to indicate destroy() // is called by the garbage collector and everything is good. // Something to keep in mind though. return 0; } /** * Write function that is called when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ public function write($sessId, $data): bool { if ($this->writesDisabled) { return true; } return $this->saveSession($sessId, $data); } /** * A function that is called internally when session data is to be saved. * * @param string $sessId The current session ID * @param string $data The session data to write * * @return bool */ abstract protected function saveSession($sessId, $data): bool; }

* * @return void */ public function writeClose() { // The assumption is that we're using PHP's ext/session. // session_write_close() will actually overwrite $_SESSION with an // empty array on completion -- which leads to a mismatch between what // is in the storage object and $_SESSION. To get around this, we // temporarily reset $_SESSION to an array, and then re-link it to // the storage object. // // Additionally, while you _can_ write to $_SESSION following a // session_write_close() operation, no changes made to it will be // flushed to the session handler. As such, we now mark the storage // object isImmutable. $storage = $this->getStorage(); if (! $storage->isImmutable()) { $_SESSION = $storage->toArray(true); session_write_close(); $storage->fromArray($_SESSION); $storage->markImmutable(); } } /** * Attempt to set the session name * * If the session has already been started, or if the name provided fails * validation, an exception will be raised. * * @param string $name * @return SessionManager * @throws Exception\InvalidArgumentException */ public function setName($name) { if ($this->sessionExists()) { throw new Exception\InvalidArgumentException( 'Cannot set session name after a session has already started'

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