Malignant bone tumors in Pediatrics. Five year experience in a pediatric referral center
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| Natura: | Artículo científico |
| Lingua: | en |
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Universidad Nacional de Colombia
2016
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| _version_ | 1876481150299406336 |
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| author | Gisela Barros |
| author_facet | Gisela Barros |
| contents | Malignant bone tumors in Pediatrics. Five year experience in a pediatric referral center Gisela Barros Ángela María Trujillo Lina Jaramillo Francy Helena Ortiz Agustín Darío Contreras Medicina Recurrence Osteosarcoma Ewing's Sarcoma Disease Progression Neoplasm Metastasis (MeSH) Background: Osteosarcoma (OS) and Ewing's Sarcoma (ES) are the two most common malignant bone tumors in children. A retrospective review of the records of children diagnosed in a pediatric hospital over a five year period (2008-2013) was performed. Objective: To present the experiences acquired during the treatment of these types of tumors and to compare the results obtained with those reported in the literature. Methodology: The database of the Oncology and Pathology Service of Fundación Hospital de la Misericordia (HOMI) was reviewed to identify patients with primary bone tumors referred for histopathology analysis. Results: 22 patients were diagnosed with OS, with a mean age of 11.9 years. 96% of cases were located in the lower extremities. All patients received neoadjuvant chemotherapy and 86% underwent surgical treatment; 13% survived. 15 patients were diagnosed with ES, with a mean age of 12.4 years. 67% of cases were located in flat bones, 53% of patients had metastasis when diagnosed, and all received neoadjuvant chemotherapy. 40% of patients received surgical intervention and 20% received radiotherapy. Survival at the completion of the reseearch was 33%.Conclusions: Cure and survival rates are lower than those reported in the literature despite efforts to improve treatments. 2016 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576364352002 https://www.redalyc.org/journal/5763/576364352002/ https://www.redalyc.org/journal/5763/576364352002/html/ https://www.redalyc.org/journal/5763/576364352002/576364352002.epub https://www.redalyc.org/journal/5763/576364352002/movil 10.15446/revfacmed.v64n3.50475 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.3 Vol.64 |
| format | Artículo científico |
| id | redalyc_576364352002 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Malignant bone tumors in Pediatrics. Five year experience in a pediatric referral center Gisela Barros Medicina Recurrence Osteosarcoma Ewing's Sarcoma Disease Progression Neoplasm Metastasis (MeSH) Malignant bone tumors in Pediatrics. Five year experience in a pediatric referral center Gisela Barros Ángela María Trujillo Lina Jaramillo Francy Helena Ortiz Agustín Darío Contreras Medicina Recurrence Osteosarcoma Ewing's Sarcoma Disease Progression Neoplasm Metastasis (MeSH) Background: Osteosarcoma (OS) and Ewing's Sarcoma (ES) are the two most common malignant bone tumors in children. A retrospective review of the records of children diagnosed in a pediatric hospital over a five year period (2008-2013) was performed. Objective: To present the experiences acquired during the treatment of these types of tumors and to compare the results obtained with those reported in the literature. Methodology: The database of the Oncology and Pathology Service of Fundación Hospital de la Misericordia (HOMI) was reviewed to identify patients with primary bone tumors referred for histopathology analysis. Results: 22 patients were diagnosed with OS, with a mean age of 11.9 years. 96% of cases were located in the lower extremities. All patients received neoadjuvant chemotherapy and 86% underwent surgical treatment; 13% survived. 15 patients were diagnosed with ES, with a mean age of 12.4 years. 67% of cases were located in flat bones, 53% of patients had metastasis when diagnosed, and all received neoadjuvant chemotherapy. 40% of patients received surgical intervention and 20% received radiotherapy. Survival at the completion of the reseearch was 33%.Conclusions: Cure and survival rates are lower than those reported in the literature despite efforts to improve treatments. 2016 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576364352002 https://www.redalyc.org/journal/5763/576364352002/ https://www.redalyc.org/journal/5763/576364352002/html/ https://www.redalyc.org/journal/5763/576364352002/576364352002.epub https://www.redalyc.org/journal/5763/576364352002/movil 10.15446/revfacmed.v64n3.50475 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.3 Vol.64 |
| title | Malignant bone tumors in Pediatrics. Five year experience in a pediatric referral center |
| topic | Medicina Recurrence Osteosarcoma Ewing's Sarcoma Disease Progression Neoplasm Metastasis (MeSH) |
| url | https://www.redalyc.org/articulo.oa?id=576364352002 https://www.redalyc.org/journal/5763/576364352002/ https://www.redalyc.org/journal/5763/576364352002/html/ https://www.redalyc.org/journal/5763/576364352002/576364352002.epub https://www.redalyc.org/journal/5763/576364352002/movil |