Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia
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| Format: | Artículo científico |
| Sprache: | en |
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Universidad Nacional de Colombia
2016
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| _version_ | 1876468257880276992 |
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| author | Ángela María Trujillo |
| author_facet | Ángela María Trujillo |
| contents | Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia Ángela María Trujillo Adriana Linares Isabel Cristina Sarmiento Medicina Pediatrics Side Effects Survival (MeSH) Lymphoblastic Leukemia Background: Acute lymphoblastic leukemia is the most common cancer in children. In developed countries, overall survival rates are around 80%, while in developing countries, survival rate is much lower due to high rates of relapse, and abandonment and complications arising from the disease treatment. Objectives: To assess induction mortality, relapse and treatment abandonment. To describe the most frequent side effects of chemotherapy. To evaluate survival rates of patients and compare the findings found in this study with the existing literature. Material and methods: A retrospective cohort study was conducted on patients aged 1 to 18 with acute lymphoblastic leukemia, who received treatment under the BFM ALL IC 2009 protocol at Fundación Hospital La Misericordia (HOMI), from November 2012 to December 2014.Results: 119 patients were included. Death occurred in two cases during induction (1.67%) and in nine (7.7%) due to treatment, all of them caused by infection/sepsis and in complete remission. Six patients abandoned treatment (5%), while seven relapses occurred (5.9%). All patients experienced some type of side effect related to chemotherapy, the most frequent being febrile neutropenia (41.2%) and grade 3-4 infections (15.8%). Overall survival and event-free survival rates were 79.9% and 73.3%, respectively. Conclusions: Evaluating complications of treatment and death allows adopting measures and strategies to reduce such complications. 2016 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576364352004 https://www.redalyc.org/journal/5763/576364352004/ https://www.redalyc.org/journal/5763/576364352004/html/ https://www.redalyc.org/journal/5763/576364352004/576364352004.epub https://www.redalyc.org/journal/5763/576364352004/movil 10.15446/revfacmed.v64n3.53961 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.3 Vol.64 |
| format | Artículo científico |
| id | redalyc_576364352004 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia Ángela María Trujillo Medicina Pediatrics Side Effects Survival (MeSH) Lymphoblastic Leukemia Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia Ángela María Trujillo Adriana Linares Isabel Cristina Sarmiento Medicina Pediatrics Side Effects Survival (MeSH) Lymphoblastic Leukemia Background: Acute lymphoblastic leukemia is the most common cancer in children. In developed countries, overall survival rates are around 80%, while in developing countries, survival rate is much lower due to high rates of relapse, and abandonment and complications arising from the disease treatment. Objectives: To assess induction mortality, relapse and treatment abandonment. To describe the most frequent side effects of chemotherapy. To evaluate survival rates of patients and compare the findings found in this study with the existing literature. Material and methods: A retrospective cohort study was conducted on patients aged 1 to 18 with acute lymphoblastic leukemia, who received treatment under the BFM ALL IC 2009 protocol at Fundación Hospital La Misericordia (HOMI), from November 2012 to December 2014.Results: 119 patients were included. Death occurred in two cases during induction (1.67%) and in nine (7.7%) due to treatment, all of them caused by infection/sepsis and in complete remission. Six patients abandoned treatment (5%), while seven relapses occurred (5.9%). All patients experienced some type of side effect related to chemotherapy, the most frequent being febrile neutropenia (41.2%) and grade 3-4 infections (15.8%). Overall survival and event-free survival rates were 79.9% and 73.3%, respectively. Conclusions: Evaluating complications of treatment and death allows adopting measures and strategies to reduce such complications. 2016 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576364352004 https://www.redalyc.org/journal/5763/576364352004/ https://www.redalyc.org/journal/5763/576364352004/html/ https://www.redalyc.org/journal/5763/576364352004/576364352004.epub https://www.redalyc.org/journal/5763/576364352004/movil 10.15446/revfacmed.v64n3.53961 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.3 Vol.64 |
| title | Intensive chemotherapy in children with acute lymphoblastic leukemia. Interim analysis in a referral center in Colombia |
| topic | Medicina Pediatrics Side Effects Survival (MeSH) Lymphoblastic Leukemia |
| url | https://www.redalyc.org/articulo.oa?id=576364352004 https://www.redalyc.org/journal/5763/576364352004/ https://www.redalyc.org/journal/5763/576364352004/html/ https://www.redalyc.org/journal/5763/576364352004/576364352004.epub https://www.redalyc.org/journal/5763/576364352004/movil |