Molecular mechanisms of autophagy and its role in cancer development
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| Format: | Artículo científico |
| Language: | en |
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Universidad Nacional de Colombia
2016
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| _version_ | 1876445375522406400 |
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| author | Kathleen Salazar-Ramírez |
| author_facet | Kathleen Salazar-Ramírez |
| contents | Molecular mechanisms of autophagy and its role in cancer development Kathleen Salazar-Ramírez Jhonny Molinares-Rodríguez Samir Bolívar-González Medicina Cancer Autophagy Tumorigenesis Proliferation (MeSH) Autophagy is an evolutionary process preserved in eukaryotes, which removes harmful components and maintains cell homeostasis in response to a variety of extracellular stimuli. It is involved in both physiological and pathological conditions, including cancer.The role of autophagy in the treatment of cancer is described as a "double-edged sword", which reflects its involvement in tumor suppression, survival and subsequent proliferation of tumor cells. Recent advances are useful for planning appropriate adjustments to inhibit or promote autophagy in order to obtain therapeutic efficacy in cancer patients. The objectives of this review are to clarify the role of autophagy in cancer and to highlight the need for more research in the field. 2016 reseña 2357-3848 https://www.redalyc.org/articulo.oa?id=576364352021 https://www.redalyc.org/journal/5763/576364352021/ https://www.redalyc.org/journal/5763/576364352021/html/ https://www.redalyc.org/journal/5763/576364352021/576364352021.epub https://www.redalyc.org/journal/5763/576364352021/movil 10.15446/revfacmed.v64n3.54152 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.3 Vol.64 |
| format | Artículo científico |
| id | redalyc_576364352021 |
| institution | Redalyc |
| language | en |
| publishDate | 2016 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Molecular mechanisms of autophagy and its role in cancer development Kathleen Salazar-Ramírez Medicina Cancer Autophagy Tumorigenesis Proliferation (MeSH) Molecular mechanisms of autophagy and its role in cancer development Kathleen Salazar-Ramírez Jhonny Molinares-Rodríguez Samir Bolívar-González Medicina Cancer Autophagy Tumorigenesis Proliferation (MeSH) Autophagy is an evolutionary process preserved in eukaryotes, which removes harmful components and maintains cell homeostasis in response to a variety of extracellular stimuli. It is involved in both physiological and pathological conditions, including cancer.The role of autophagy in the treatment of cancer is described as a "double-edged sword", which reflects its involvement in tumor suppression, survival and subsequent proliferation of tumor cells. Recent advances are useful for planning appropriate adjustments to inhibit or promote autophagy in order to obtain therapeutic efficacy in cancer patients. The objectives of this review are to clarify the role of autophagy in cancer and to highlight the need for more research in the field. 2016 reseña 2357-3848 https://www.redalyc.org/articulo.oa?id=576364352021 https://www.redalyc.org/journal/5763/576364352021/ https://www.redalyc.org/journal/5763/576364352021/html/ https://www.redalyc.org/journal/5763/576364352021/576364352021.epub https://www.redalyc.org/journal/5763/576364352021/movil 10.15446/revfacmed.v64n3.54152 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.3 Vol.64 |
| title | Molecular mechanisms of autophagy and its role in cancer development |
| topic | Medicina Cancer Autophagy Tumorigenesis Proliferation (MeSH) |
| url | https://www.redalyc.org/articulo.oa?id=576364352021 https://www.redalyc.org/journal/5763/576364352021/ https://www.redalyc.org/journal/5763/576364352021/html/ https://www.redalyc.org/journal/5763/576364352021/576364352021.epub https://www.redalyc.org/journal/5763/576364352021/movil |