Zika virus: clinical manifestations and treatment at a primary care institution in Colombia
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| Format: | Artículo científico |
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Universidad Nacional de Colombia
2020
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| author | Juan Daniel Castrillón-Spitia |
| author_facet | Juan Daniel Castrillón-Spitia |
| contents | Zika virus: clinical manifestations and treatment at a primary care institution in Colombia Juan Daniel Castrillón-Spitia Alejandra Lopez-Villegas Estefanía Morales-Jimenez Germán Eduardo Rueda-Merchán Valentina Ramírez-Zapata Carmen Luisa Betancur-Pulgarín Medicina Anti Zika Virus Drug Therapy Acetaminophen Inflammatory Agents Introduction: Although Zika virus cases have been reported in Colombia since 2015, its clinical and pharmacological characteristics have not yet been described.Objective: To describe the main clinical manifestations and sociodemographic characteristics of patients diagnosed with Zika and the treatment provided to them at a primary care hospital in a municipality of Colombia.Materials and methods: Descriptive cross-sectional study. The study population consisted of patients diagnosed with Zika between January 1 and July 25, 2016 at a primary care hospital. Sociodemographic, clinical, and pharmacological variables, as well as adverse clinical outcomes associated with the infection were included. Descriptive statistics were performed. A x2 test was used for categorical variables, and a multivariate analysis was conducted using Epi info 7.1 software. Results: 254 individuals infected with Zika virus during the study period were identified, and Zika diagnosis was more frequent in women (68.5%). Regarding treatment, 90.9% of the cases were treated using acetaminophen. The most commonly reported symptoms were rash (81.1%) and pruritus (55.9%). In addition, antihistamines were the most frequent comedication (31.9%). Factors such as being a woman, being pregnant and inpatient treatment were associated with adverse clinical outcomes.Conclusion: The clinical manifestations described here are similar to those reported in other populations. Furthermore, inappropriate pharmacological management practices that can lead to complications in this population, such as bleeding, were observed in some cases. Thus, educational interventions on the proper prescription of medications for treating this disease aimed at general physicians working in Zika affected areas must be implemented to improve the prognosis of these patients. 2020 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576366547003 https://www.redalyc.org/journal/5763/576366547003/ https://www.redalyc.org/journal/5763/576366547003/html/ https://www.redalyc.org/journal/5763/576366547003/576366547003.epub https://www.redalyc.org/journal/5763/576366547003/movil 10.15446/revfacmed.v68n2.74926 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.2 Vol.68 |
| format | Artículo científico |
| id | redalyc_576366547003 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Zika virus: clinical manifestations and treatment at a primary care institution in Colombia Juan Daniel Castrillón-Spitia Medicina Anti Zika Virus Drug Therapy Acetaminophen Inflammatory Agents Zika virus: clinical manifestations and treatment at a primary care institution in Colombia Juan Daniel Castrillón-Spitia Alejandra Lopez-Villegas Estefanía Morales-Jimenez Germán Eduardo Rueda-Merchán Valentina Ramírez-Zapata Carmen Luisa Betancur-Pulgarín Medicina Anti Zika Virus Drug Therapy Acetaminophen Inflammatory Agents Introduction: Although Zika virus cases have been reported in Colombia since 2015, its clinical and pharmacological characteristics have not yet been described.Objective: To describe the main clinical manifestations and sociodemographic characteristics of patients diagnosed with Zika and the treatment provided to them at a primary care hospital in a municipality of Colombia.Materials and methods: Descriptive cross-sectional study. The study population consisted of patients diagnosed with Zika between January 1 and July 25, 2016 at a primary care hospital. Sociodemographic, clinical, and pharmacological variables, as well as adverse clinical outcomes associated with the infection were included. Descriptive statistics were performed. A x2 test was used for categorical variables, and a multivariate analysis was conducted using Epi info 7.1 software. Results: 254 individuals infected with Zika virus during the study period were identified, and Zika diagnosis was more frequent in women (68.5%). Regarding treatment, 90.9% of the cases were treated using acetaminophen. The most commonly reported symptoms were rash (81.1%) and pruritus (55.9%). In addition, antihistamines were the most frequent comedication (31.9%). Factors such as being a woman, being pregnant and inpatient treatment were associated with adverse clinical outcomes.Conclusion: The clinical manifestations described here are similar to those reported in other populations. Furthermore, inappropriate pharmacological management practices that can lead to complications in this population, such as bleeding, were observed in some cases. Thus, educational interventions on the proper prescription of medications for treating this disease aimed at general physicians working in Zika affected areas must be implemented to improve the prognosis of these patients. 2020 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576366547003 https://www.redalyc.org/journal/5763/576366547003/ https://www.redalyc.org/journal/5763/576366547003/html/ https://www.redalyc.org/journal/5763/576366547003/576366547003.epub https://www.redalyc.org/journal/5763/576366547003/movil 10.15446/revfacmed.v68n2.74926 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.2 Vol.68 |
| title | Zika virus: clinical manifestations and treatment at a primary care institution in Colombia |
| topic | Medicina Anti Zika Virus Drug Therapy Acetaminophen Inflammatory Agents |
| url | https://www.redalyc.org/articulo.oa?id=576366547003 https://www.redalyc.org/journal/5763/576366547003/ https://www.redalyc.org/journal/5763/576366547003/html/ https://www.redalyc.org/journal/5763/576366547003/576366547003.epub https://www.redalyc.org/journal/5763/576366547003/movil |