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| Format: | Artículo científico |
| Language: | en |
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Universidad Nacional de Colombia
2020
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| Online Access: | https://www.redalyc.org/articulo.oa?id=576366603002 https://www.redalyc.org/journal/5763/576366603002/ https://www.redalyc.org/journal/5763/576366603002/html/ https://www.redalyc.org/journal/5763/576366603002/576366603002.epub https://www.redalyc.org/journal/5763/576366603002/movil |
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| author | Liliana Ladino |
| author_facet | Liliana Ladino |
| contents | Detection of anti-tissue transglutaminase IgA antibodies (tTG IgA) in children with type 1 diabetes mellitus Liliana Ladino Adriana León Oscar Quintero Rodrigo Vázquez Angélica Veloza Camila Céspedes Medicina Type 1 Glutens Anthropometry Digestive (MeSH) Diabetes Mellitus Introduction: Children with type 1 diabetes mellitus (DM1) are more likely to develop celiac disease (CD), which is an underdiagnosed condition due to its variable clinical presentation. Therefore, children with DM1 require periodic monitoring to achieve an early diagnosis of CD. Objectives: To identify positivity for the detection of anti-tissue transglutaminase IgA antibodies (tTG-IgA) in children with DM1, as well as to describe gastrointestinal (GI) symptoms, anthropometric status indicators and gluten intake levels.Materials and methods: Descriptive cross-sectional study. The population was composed of children with DM1 who attended the outpatient service of two pediatric endocrinology centers in Bogotá, Colombia. The Biocard-Celiac® test was used to detect the presence of tTG-IgA. In addition, participants were asked about their GI symptoms and underwent an anthropometric nutritional assessment. Gluten intake was assessed by recording dietary intake for 72 hours. A statistical data analysis was performed using the SPSS software version 22.0. Results: The final sample included 45 children with an average age of 10.6±4.1 years, of which 53% were males. None of the participants had a positive result in the tTG-IgA test. The most frequent GI symptoms were flatulence (48.9%) and abdominal pain (28.9%). Only 3 children (6.7%) were below the height-for-age standard. The average gluten intake was 5.29±3.02 g/day. Conclusions: Although children with DM1 are at increased risk of developing CD, none of the participants tested positive for tTG-IgA. 2020 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576366603002 https://www.redalyc.org/journal/5763/576366603002/ https://www.redalyc.org/journal/5763/576366603002/html/ https://www.redalyc.org/journal/5763/576366603002/576366603002.epub https://www.redalyc.org/journal/5763/576366603002/movil 10.15446/revfacmed.v68n3.75597 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.3 Vol.68 |
| format | Artículo científico |
| id | redalyc_576366603002 |
| language | en |
| publishDate | 2020 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Detection of anti-tissue transglutaminase IgA antibodies (tTG IgA) in children with type 1 diabetes mellitus Liliana Ladino Medicina Type 1 Glutens Anthropometry Digestive (MeSH) Diabetes Mellitus Detection of anti-tissue transglutaminase IgA antibodies (tTG IgA) in children with type 1 diabetes mellitus Liliana Ladino Adriana León Oscar Quintero Rodrigo Vázquez Angélica Veloza Camila Céspedes Medicina Type 1 Glutens Anthropometry Digestive (MeSH) Diabetes Mellitus Introduction: Children with type 1 diabetes mellitus (DM1) are more likely to develop celiac disease (CD), which is an underdiagnosed condition due to its variable clinical presentation. Therefore, children with DM1 require periodic monitoring to achieve an early diagnosis of CD. Objectives: To identify positivity for the detection of anti-tissue transglutaminase IgA antibodies (tTG-IgA) in children with DM1, as well as to describe gastrointestinal (GI) symptoms, anthropometric status indicators and gluten intake levels.Materials and methods: Descriptive cross-sectional study. The population was composed of children with DM1 who attended the outpatient service of two pediatric endocrinology centers in Bogotá, Colombia. The Biocard-Celiac® test was used to detect the presence of tTG-IgA. In addition, participants were asked about their GI symptoms and underwent an anthropometric nutritional assessment. Gluten intake was assessed by recording dietary intake for 72 hours. A statistical data analysis was performed using the SPSS software version 22.0. Results: The final sample included 45 children with an average age of 10.6±4.1 years, of which 53% were males. None of the participants had a positive result in the tTG-IgA test. The most frequent GI symptoms were flatulence (48.9%) and abdominal pain (28.9%). Only 3 children (6.7%) were below the height-for-age standard. The average gluten intake was 5.29±3.02 g/day. Conclusions: Although children with DM1 are at increased risk of developing CD, none of the participants tested positive for tTG-IgA. 2020 artículo científico 2357-3848 https://www.redalyc.org/articulo.oa?id=576366603002 https://www.redalyc.org/journal/5763/576366603002/ https://www.redalyc.org/journal/5763/576366603002/html/ https://www.redalyc.org/journal/5763/576366603002/576366603002.epub https://www.redalyc.org/journal/5763/576366603002/movil 10.15446/revfacmed.v68n3.75597 en http://www.redalyc.org/revista.oa?id=5763 Revista de la Facultad de Medicina application/pdf Universidad Nacional de Colombia Revista de la Facultad de Medicina (Colombia) Num.3 Vol.68 |
| title | Detection of anti-tissue transglutaminase IgA antibodies (tTG IgA) in children with type 1 diabetes mellitus |
| topic | Medicina Type 1 Glutens Anthropometry Digestive (MeSH) Diabetes Mellitus |
| url | https://www.redalyc.org/articulo.oa?id=576366603002 https://www.redalyc.org/journal/5763/576366603002/ https://www.redalyc.org/journal/5763/576366603002/html/ https://www.redalyc.org/journal/5763/576366603002/576366603002.epub https://www.redalyc.org/journal/5763/576366603002/movil |