Otro sistema de transmisión opioide en el cerebro de los mamíferos. Endomorfinas y receptor opioide mu. Parte I
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| Format: | Artículo científico |
| Language: | en |
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Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2000
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| _version_ | 1876479188923318272 |
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| author | Aline Morales |
| author_facet | Aline Morales |
| contents | Otro sistema de transmisión opioide en el cerebro de los mamíferos. Endomorfinas y receptor opioide mu. Parte I Aline Morales Armando Valdés Iván Martínez Philippe Leff Rodolfo Acevedo Juan Carlos Calva Benito Antón Medicina Nociception trasmission mu receptor opioid agonists endogenous opiates The reception of signals from nociceptive stimuli is transmittedthrough primary afferents that project to the dorsal horn of thespinal cord where axons from these nerve fibers terminateand make synaptic contacts with neurons projecting tosupraspinal regions of the brain and with local interneuronslocalized in the superficial layers of the dorsal horn. Spinaland supraspinal nociceptive transmission is controlled by theneuronal release of chemical transmitters that either activateand modulate as well the incoming nociceptive signalsconveyed by a complex neuron network involving ascendingand descending neural pathways that control the nociceptivetransmission along the brain of mammals. Stimulation of thesupraspinal regions of the brain is known to produce aprolonged and profound analgesia as well as a profoundsupression of activity of nociceptive pathways. Similarly, opiatealkaloids (morphine, etorphine) as well as several endogenousopioids (encephalins, β-endorphin) generate analgesic effectsin rodents by interacting and activating different opioidreceptors such as the mu and delta opioid receptor subtypeslocalizad in neurons that participate in the modulation ofnociceptive transmission. New members of the brain endogenousopioid peptides superfamily have just been recentlyidentified, isolated, characterized and named as endomorphin-1 and endomorphin-2. These peptides not only produce aprofound and prolonged spinal and supraspinal analgesia, butthey also seem to be the first natural opioid ligands to bindwith high affinity and avidity to the mu opioid receptor subtype. 2000 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58212307 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.1 Vol.23 |
| format | Artículo científico |
| id | redalyc_58212307 |
| institution | Redalyc |
| language | en |
| publishDate | 2000 |
| publisher | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz |
| spellingShingle | Otro sistema de transmisión opioide en el cerebro de los mamíferos. Endomorfinas y receptor opioide mu. Parte I Aline Morales Medicina Nociception trasmission mu receptor opioid agonists endogenous opiates Otro sistema de transmisión opioide en el cerebro de los mamíferos. Endomorfinas y receptor opioide mu. Parte I Aline Morales Armando Valdés Iván Martínez Philippe Leff Rodolfo Acevedo Juan Carlos Calva Benito Antón Medicina Nociception trasmission mu receptor opioid agonists endogenous opiates The reception of signals from nociceptive stimuli is transmittedthrough primary afferents that project to the dorsal horn of thespinal cord where axons from these nerve fibers terminateand make synaptic contacts with neurons projecting tosupraspinal regions of the brain and with local interneuronslocalized in the superficial layers of the dorsal horn. Spinaland supraspinal nociceptive transmission is controlled by theneuronal release of chemical transmitters that either activateand modulate as well the incoming nociceptive signalsconveyed by a complex neuron network involving ascendingand descending neural pathways that control the nociceptivetransmission along the brain of mammals. Stimulation of thesupraspinal regions of the brain is known to produce aprolonged and profound analgesia as well as a profoundsupression of activity of nociceptive pathways. Similarly, opiatealkaloids (morphine, etorphine) as well as several endogenousopioids (encephalins, β-endorphin) generate analgesic effectsin rodents by interacting and activating different opioidreceptors such as the mu and delta opioid receptor subtypeslocalizad in neurons that participate in the modulation ofnociceptive transmission. New members of the brain endogenousopioid peptides superfamily have just been recentlyidentified, isolated, characterized and named as endomorphin-1 and endomorphin-2. These peptides not only produce aprofound and prolonged spinal and supraspinal analgesia, butthey also seem to be the first natural opioid ligands to bindwith high affinity and avidity to the mu opioid receptor subtype. 2000 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58212307 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.1 Vol.23 |
| title | Otro sistema de transmisión opioide en el cerebro de los mamíferos. Endomorfinas y receptor opioide mu. Parte I |
| topic | Medicina Nociception trasmission mu receptor opioid agonists endogenous opiates |
| url | https://www.redalyc.org/articulo.oa?id=58212307 |