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| Format: | Artículo científico |
| Language: | en |
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Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2000
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| Online Access: | https://www.redalyc.org/articulo.oa?id=58222307 |
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Table of Contents:
- Cómo actúa la progesterona sobre el sistema nervioso central Carlos M. Contreras Ana G. Gutiérrez García José Luis Díaz Meza Medicina GABA Anxiety depression progesterone neurosteroids The brain has an enzymatic ability to biosynthesize cholesterol,which is a predecessor of all steroids. Therefore, progesterone,a gonadal steroid, is also biosynthesized in the nervoussystem by glial cells, and possibly by certain neuronalpopulations as well. Progesterone and its reduced metabolitesexert a wide spectrum of biological activity on the centraland peripheral nervous system. These effects not only affectthe reproductive regulation, but also exert multiple actions onthe brain when acting directly on the membrane receptors,thus reproducing some actions of the neurotransmitters forwhich a series of effects associated with diverse behavior patternshave been proposed. The presence of this steroid in differentregions of the brain seems to play a neuromodulatoryphysiological role in the development of stress and aggression,and influence mood and sexual behavior. Its designationas neurosteroids is justified. The effects of progesterone onthe central nervous system involves both genomic and nongenomic actions on different neurotransmission systems. Diverseclinical and experimental studies suggest that progesterone,besides exerting trophic functions through paracrine/autocrine actions, is also able to modulate systems of membranereceptors, such as the serotonergic, noradrenergic anddopaminergic systems. It is important to point out that thesefour neurotransmitters have been involved in depression andin the actions of antidepressants, particularly in the GABA,and aiso in anxiety processes... 2000 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58222307 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.2 Vol.23