El polimorfismo 5-HTTLPR y el intento suicida en adolescentes deprimidos
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| Format: | Artículo científico |
| Sprache: | es |
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Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2014
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| author | Emmanuel I. Sarmiento Hernández |
| author_facet | Emmanuel I. Sarmiento Hernández |
| contents | El polimorfismo 5-HTTLPR y el intento suicida en adolescentes deprimidos Emmanuel I. Sarmiento Hernández Rosa Elena Ulloa Flores Mirna Esthela Brenes Prats Beatriz Camarena Medellín Alejandro Aguilar García Sandra Hernández Muñoz Medicina suicide genetics depression Adolescents Suicide is a common cause of death in adolescents, being mainly associated with depression. In addition, the “SS” genotype and the “S” allele of 5-HTTLPR polymorphism of SLC6A4 gene of serotonin transporter have been associated with suicidal behavior. The aims of the present study were to compare the frequency of the polymorphism of SLC6A4 gene in depressed adolescents with and without history of suicidal attempt and to determine if the “SS” genotype was associated with specific clinical features. The study examined 53 adolescents who were evaluated with the Di- agnostic Interview Schedule for Affective Disorders and Schizophrenia for school-aged children-present and lifetime version (K-SADS-PL). A DNA sample was obtained and 5HTTLPR polymorphisms of SLC6A4 gene were analyzed. Results There were no differences in the frequency of genotype and allele fre- quencies between groups. However, patients with the “SS” genotype reported a higher frequency of hopelessness and a greater number of suicide attempts. Conclusions The frequency of “SS” genotype did not differ between patients with and without suicidal behavior, but patients with this genotype exhib- ited differences in clinical features of depression which need further study. Key words: Adolescents, suicide, depression, genetics. 2014 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58231307002 es http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.2 Vol.37 |
| format | Artículo científico |
| id | redalyc_58231307002 |
| institution | Redalyc |
| language | es |
| publishDate | 2014 |
| publisher | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz |
| spellingShingle | El polimorfismo 5-HTTLPR y el intento suicida en adolescentes deprimidos Emmanuel I. Sarmiento Hernández Medicina suicide genetics depression Adolescents El polimorfismo 5-HTTLPR y el intento suicida en adolescentes deprimidos Emmanuel I. Sarmiento Hernández Rosa Elena Ulloa Flores Mirna Esthela Brenes Prats Beatriz Camarena Medellín Alejandro Aguilar García Sandra Hernández Muñoz Medicina suicide genetics depression Adolescents Suicide is a common cause of death in adolescents, being mainly associated with depression. In addition, the “SS” genotype and the “S” allele of 5-HTTLPR polymorphism of SLC6A4 gene of serotonin transporter have been associated with suicidal behavior. The aims of the present study were to compare the frequency of the polymorphism of SLC6A4 gene in depressed adolescents with and without history of suicidal attempt and to determine if the “SS” genotype was associated with specific clinical features. The study examined 53 adolescents who were evaluated with the Di- agnostic Interview Schedule for Affective Disorders and Schizophrenia for school-aged children-present and lifetime version (K-SADS-PL). A DNA sample was obtained and 5HTTLPR polymorphisms of SLC6A4 gene were analyzed. Results There were no differences in the frequency of genotype and allele fre- quencies between groups. However, patients with the “SS” genotype reported a higher frequency of hopelessness and a greater number of suicide attempts. Conclusions The frequency of “SS” genotype did not differ between patients with and without suicidal behavior, but patients with this genotype exhib- ited differences in clinical features of depression which need further study. Key words: Adolescents, suicide, depression, genetics. 2014 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58231307002 es http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.2 Vol.37 |
| title | El polimorfismo 5-HTTLPR y el intento suicida en adolescentes deprimidos |
| topic | Medicina suicide genetics depression Adolescents |
| url | https://www.redalyc.org/articulo.oa?id=58231307002 |