Synaptic plasticity : Understanding the neurobiological mechanisms of learning and memory. Part II
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| Format: | Artículo científico |
| Language: | en |
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Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2001
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| _version_ | 1876455967468552192 |
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| author | Juan C. Calva |
| author_facet | Juan C. Calva |
| contents | Synaptic plasticity : Understanding the neurobiological mechanisms of learning and memory. Part II Juan C. Calva Philippe Leff Rodolfo Acevedo Benito Anton Héctor Romo Parra Rafael Gutiérrez Medicina long memory synapses learning training Plasticity of the nervous system has been related to learning and memoryprocessing as early as the beginning of the century; although, remotely,brain plasticity in relation to behavior has been connoted over the past two centuries. However, four decades ago, several evidences have shown that experience and training induce neural changes, showing that major neuroanatomical, neurochemical as well as molecular changes are required for the establishment of a long-term memory process. Early experimental procedures showed that differential experience, training and/or informal experience could produce altered quantified changes in the brain of mammals. Moreover, neuropsychologists have emphasized that different memories could be localized in separate cortical areas of the brain, but updated evidences assert that memory systems are specifically distributedin exclusive neural networks in the cortex. For instance, the same corticalsystems that lead us to perceive and move in our environment, are used asneural substrates for memory retrieval. Such memories are the result of the repeated activity of millions of neurons assembled into distinct neural networks, where plastic changes in synaptic function leads to the strengthening of the same synaptic connections with the result ofreconstructed permanent traces that lead to remembrance (Hebb Postulate). Elementary forms of learning and memory have been studiedin simple neural systems of invertebrates, and as such have led the way for understanding much of the electrophysiological and neurochemical events occurring during LTP. Long-term potentiation (LTP) is the result of theincrease in the strength of synaptic transmission, lasting as long as can bemeasured from hours to days. LTP has been detected in several areas ofthe brain, particularly, in the hippocampus, amygdala, and cortex, including several related limbic structures in the mammalian brain. LTP represents up to date the best model available for understanding the cellular basis of learning and memory in the central nervous system of mammals including humans. 2001 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58232407 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.3 Vol.24 |
| format | Artículo científico |
| id | redalyc_58232407 |
| institution | Redalyc |
| language | en |
| publishDate | 2001 |
| publisher | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz |
| spellingShingle | Synaptic plasticity : Understanding the neurobiological mechanisms of learning and memory. Part II Juan C. Calva Medicina long memory synapses learning training Synaptic plasticity : Understanding the neurobiological mechanisms of learning and memory. Part II Juan C. Calva Philippe Leff Rodolfo Acevedo Benito Anton Héctor Romo Parra Rafael Gutiérrez Medicina long memory synapses learning training Plasticity of the nervous system has been related to learning and memoryprocessing as early as the beginning of the century; although, remotely,brain plasticity in relation to behavior has been connoted over the past two centuries. However, four decades ago, several evidences have shown that experience and training induce neural changes, showing that major neuroanatomical, neurochemical as well as molecular changes are required for the establishment of a long-term memory process. Early experimental procedures showed that differential experience, training and/or informal experience could produce altered quantified changes in the brain of mammals. Moreover, neuropsychologists have emphasized that different memories could be localized in separate cortical areas of the brain, but updated evidences assert that memory systems are specifically distributedin exclusive neural networks in the cortex. For instance, the same corticalsystems that lead us to perceive and move in our environment, are used asneural substrates for memory retrieval. Such memories are the result of the repeated activity of millions of neurons assembled into distinct neural networks, where plastic changes in synaptic function leads to the strengthening of the same synaptic connections with the result ofreconstructed permanent traces that lead to remembrance (Hebb Postulate). Elementary forms of learning and memory have been studiedin simple neural systems of invertebrates, and as such have led the way for understanding much of the electrophysiological and neurochemical events occurring during LTP. Long-term potentiation (LTP) is the result of theincrease in the strength of synaptic transmission, lasting as long as can bemeasured from hours to days. LTP has been detected in several areas ofthe brain, particularly, in the hippocampus, amygdala, and cortex, including several related limbic structures in the mammalian brain. LTP represents up to date the best model available for understanding the cellular basis of learning and memory in the central nervous system of mammals including humans. 2001 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58232407 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.3 Vol.24 |
| title | Synaptic plasticity : Understanding the neurobiological mechanisms of learning and memory. Part II |
| topic | Medicina long memory synapses learning training |
| url | https://www.redalyc.org/articulo.oa?id=58232407 |