Neurobiology of addiction: neuroanatomical, neurochemical, molecular and genetic aspects of morphine and cocaine addiction. Part III
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| Format: | Artículo científico |
| Langue: | en |
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Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2000
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| _version_ | 1876422915358982144 |
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| author | Armando Valdez |
| author_facet | Armando Valdez |
| contents | Neurobiology of addiction: neuroanatomical, neurochemical, molecular and genetic aspects of morphine and cocaine addiction. Part III Armando Valdez Carlos Lima Philippe Leff Aline Morales Juan Carlos Calva Mayra Medécigo Rodolfo Acevedo Benito Antón Medicina neuron cocaine Morphine dopamine addiction Drugs of abuse, including opiates and psychostimulants,induce both short and long-lasting effects on behavior andsimilarly exert profound changes in the neural circuits wherethese drugs operate producing neuronal adaptations and longterm changes in synaptic plasticity. Such neuroadaptationoccur as homestatic responses to excessive drug stimulationin assotiation with a specific pattern of learned behaviorsinduced by repeated drug stimulation. Although suchneuroadaptive mechanisms may underlie several aspects ofdrug dependence and withdrawal, they do not account for thecompulsive nature of drug seeking behavior or the tendencyto relapse. Most drugs of abuse alter a set of molecularmechanisms involved in normal cellular processes that underliethe physiological aspects of learning and memory wherestimulation of dopamine D1 receptors, activation of the cAMP/PKA/CREB intracellular signaling transduction pathway,alteration of gene expression, and the enhanced synapticrearrangements currently occur in the acquisition of suchbehaviors. Therefore, drug addiction, as a chronic relapsingdisorder, reflects novel adaptative changes occurring in specificpatterns of synaptic connectivity as occurs in normal memoryformation. Neural mechanisms that underlie both tolerance andsensitization might coexist and one can unmask the expressionof the other after abrupt drug cessation (tolerance) or afterprolonged removal of drug administration (sensitization). These effects can even persist for a long time after ending drug administration.Although many of the cellular and molecular adaptationselucidated up to date reflect those neuroadaptationsthat correlate with altered behavior responses during drugaddiction, there are still many unsolved non response questionssuch as; the precise molecular events implicated in the permanentechanges in neurons and neural transmission systemsthat are responsible for the adaptative behavioral responsesduring relapse, and drug seeking behavior during chronic drugaddiction. 2000 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58252307 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.5 Vol.23 |
| format | Artículo científico |
| id | redalyc_58252307 |
| institution | Redalyc |
| language | en |
| publishDate | 2000 |
| publisher | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz |
| spellingShingle | Neurobiology of addiction: neuroanatomical, neurochemical, molecular and genetic aspects of morphine and cocaine addiction. Part III Armando Valdez Medicina neuron cocaine Morphine dopamine addiction Neurobiology of addiction: neuroanatomical, neurochemical, molecular and genetic aspects of morphine and cocaine addiction. Part III Armando Valdez Carlos Lima Philippe Leff Aline Morales Juan Carlos Calva Mayra Medécigo Rodolfo Acevedo Benito Antón Medicina neuron cocaine Morphine dopamine addiction Drugs of abuse, including opiates and psychostimulants,induce both short and long-lasting effects on behavior andsimilarly exert profound changes in the neural circuits wherethese drugs operate producing neuronal adaptations and longterm changes in synaptic plasticity. Such neuroadaptationoccur as homestatic responses to excessive drug stimulationin assotiation with a specific pattern of learned behaviorsinduced by repeated drug stimulation. Although suchneuroadaptive mechanisms may underlie several aspects ofdrug dependence and withdrawal, they do not account for thecompulsive nature of drug seeking behavior or the tendencyto relapse. Most drugs of abuse alter a set of molecularmechanisms involved in normal cellular processes that underliethe physiological aspects of learning and memory wherestimulation of dopamine D1 receptors, activation of the cAMP/PKA/CREB intracellular signaling transduction pathway,alteration of gene expression, and the enhanced synapticrearrangements currently occur in the acquisition of suchbehaviors. Therefore, drug addiction, as a chronic relapsingdisorder, reflects novel adaptative changes occurring in specificpatterns of synaptic connectivity as occurs in normal memoryformation. Neural mechanisms that underlie both tolerance andsensitization might coexist and one can unmask the expressionof the other after abrupt drug cessation (tolerance) or afterprolonged removal of drug administration (sensitization). These effects can even persist for a long time after ending drug administration.Although many of the cellular and molecular adaptationselucidated up to date reflect those neuroadaptationsthat correlate with altered behavior responses during drugaddiction, there are still many unsolved non response questionssuch as; the precise molecular events implicated in the permanentechanges in neurons and neural transmission systemsthat are responsible for the adaptative behavioral responsesduring relapse, and drug seeking behavior during chronic drugaddiction. 2000 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58252307 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.5 Vol.23 |
| title | Neurobiology of addiction: neuroanatomical, neurochemical, molecular and genetic aspects of morphine and cocaine addiction. Part III |
| topic | Medicina neuron cocaine Morphine dopamine addiction |
| url | https://www.redalyc.org/articulo.oa?id=58252307 |