Effect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders
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| Natura: | Artículo científico |
| Lingua: | en |
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Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2018
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| _version_ | 1876479076779163648 |
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| author | Mirna Edith Morales-Marín |
| author_facet | Mirna Edith Morales-Marín |
| contents | Effect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders Mirna Edith Morales-Marín Miriam Aguilar Lilia Albores Ana Ballesteros Xóchitl Castro Carlos Chicalote Amalia Gómez Nora Gutiérrez Nuria Lanzagorta Fernando López Carla Márquez Nimsi Morales Omar Náfate Patricia Sánchez Ana María Balboa Humberto Nicolini Medicina BDNF Mexican population autism spectrum disorders single nucleotide polymorphism Introduction: The study of autistic spectrum disorders (ASD) at the genetic level is extremely important to understand their origin. In Mexico, there are few works addressed from this perspective.Objective: We investigated the role of the Brain Derived Neurotrophic Factor (BDNF) gene variant rs6265 G/A for single nucleotide polymorphism analysis in Mexican children with ASD using a case-control association design.Method: We made a pilot study by case-control analysis adjusting by gender, age, and ancestry.Results: Our study found no association between the BDNF rs6265 gene polymorphism and ASD p = .419, OR = 1.597 (.514, 4.967)Discussion and conclusion: Worldwide, the results of case-control association studies with the rs6265 of BDNF are controversial and do not always replicate. This may be due to the ethnicity of our population and additional factors not studied in the present work. Our study suggests that the SNP rs6265 is not contributing for ASD susceptibility in Mexican population. 2018 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58257575003 https://www.redalyc.org/journal/582/58257575003/ https://www.redalyc.org/journal/582/58257575003/html/ https://www.redalyc.org/journal/582/58257575003/58257575003.epub https://www.redalyc.org/journal/582/58257575003/movil 10.17711/SM.0185-3325.2018.019 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.3 Vol.41 |
| format | Artículo científico |
| id | redalyc_58257575003 |
| institution | Redalyc |
| language | en |
| publishDate | 2018 |
| publisher | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz |
| spellingShingle | Effect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders Mirna Edith Morales-Marín Medicina BDNF Mexican population autism spectrum disorders single nucleotide polymorphism Effect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders Mirna Edith Morales-Marín Miriam Aguilar Lilia Albores Ana Ballesteros Xóchitl Castro Carlos Chicalote Amalia Gómez Nora Gutiérrez Nuria Lanzagorta Fernando López Carla Márquez Nimsi Morales Omar Náfate Patricia Sánchez Ana María Balboa Humberto Nicolini Medicina BDNF Mexican population autism spectrum disorders single nucleotide polymorphism Introduction: The study of autistic spectrum disorders (ASD) at the genetic level is extremely important to understand their origin. In Mexico, there are few works addressed from this perspective.Objective: We investigated the role of the Brain Derived Neurotrophic Factor (BDNF) gene variant rs6265 G/A for single nucleotide polymorphism analysis in Mexican children with ASD using a case-control association design.Method: We made a pilot study by case-control analysis adjusting by gender, age, and ancestry.Results: Our study found no association between the BDNF rs6265 gene polymorphism and ASD p = .419, OR = 1.597 (.514, 4.967)Discussion and conclusion: Worldwide, the results of case-control association studies with the rs6265 of BDNF are controversial and do not always replicate. This may be due to the ethnicity of our population and additional factors not studied in the present work. Our study suggests that the SNP rs6265 is not contributing for ASD susceptibility in Mexican population. 2018 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58257575003 https://www.redalyc.org/journal/582/58257575003/ https://www.redalyc.org/journal/582/58257575003/html/ https://www.redalyc.org/journal/582/58257575003/58257575003.epub https://www.redalyc.org/journal/582/58257575003/movil 10.17711/SM.0185-3325.2018.019 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.3 Vol.41 |
| title | Effect of the polymorphism BDNF rs6265 G/A in Mexican outpatient children with autism spectrum disorders |
| topic | Medicina BDNF Mexican population autism spectrum disorders single nucleotide polymorphism |
| url | https://www.redalyc.org/articulo.oa?id=58257575003 https://www.redalyc.org/journal/582/58257575003/ https://www.redalyc.org/journal/582/58257575003/html/ https://www.redalyc.org/journal/582/58257575003/58257575003.epub https://www.redalyc.org/journal/582/58257575003/movil |