Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2019
|
| Subjects: | |
| Online Access: | https://www.redalyc.org/articulo.oa?id=58262334007 https://www.redalyc.org/journal/582/58262334007/ https://www.redalyc.org/journal/582/58262334007/html/ https://www.redalyc.org/journal/582/58262334007/58262334007.epub https://www.redalyc.org/journal/582/58262334007/movil |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Effect of postictal process in motor deficit and monoaminergic concentration in hippocampus, cerebellum, and cortex Alberto Avila-Luna Antonio Bueno-Nava José Luis Cortes-Altamirano Samuel Reyes-Long Cindy Bandala Alfonso Alfaro-Rodríguez Medicina rat serotonin postictal monoamines motor deficit Introduction. Systemic administration of pentylenetetrazole (PTZ) causes brain damage (BD), and triggers a series of morphological and neurochemical changes, which in turn bring about behavioral, cognitive, and motor deficits. Serotonin (5-HT), dopamine (DA), and noradrenaline (NA) levels are controlled by various brain structures and these levels are related to motor activity; however, the concentration of these neurotransmitters during the postictal process remains unknown. Objective. We investigated the concentration of 5-HT, NA and DA in the hippocampus, cerebellum, and cortex on motor deficit during the postictal stage. Method. Eighteen male Wistar rats (300 g) assigned to two groups: control (n = 9, saline solution) and experimental (n = 9, PTZ) were used. Myoclonic shakes were counted and motor behavior assessments were recorded during three hours post PTZ injection (90 mg/kg). The cortex, cerebellum, and hippocampus of each rat were dissected to determine the 5-HT, DA, and NA concentration by high performance liquid chromatography. Results. PTZ induced a significant increase in total 5-HT and DA levels in the hippocampus and cortex; in the cerebellum there was a significant increase in the concentration of 5-HT and NA. The presence of myoclonic shakes as well as a marked motor deficit in the experimental group were significantly different in comparison to the control. Discussion and conclusion. 5-HT modifies the concentration of other monoamines directly involved in motor aspects such as NA and DA in the hippocampus, cerebellum, and cortex during the postictal process. 2019 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58262334007 https://www.redalyc.org/journal/582/58262334007/ https://www.redalyc.org/journal/582/58262334007/html/ https://www.redalyc.org/journal/582/58262334007/58262334007.epub https://www.redalyc.org/journal/582/58262334007/movil 10.17711/SM.0185-3325.2019.032 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.5 Vol.42