El receptor ORL-1 y su péptido endógeno, la nociceptina/orfanina FQ. Nuevos miembros de la familia de los opioides
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| Format: | Artículo científico |
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Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2001
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| author | Eduardo Sánchez |
| author_facet | Eduardo Sánchez |
| contents | El receptor ORL-1 y su péptido endógeno, la nociceptina/orfanina FQ. Nuevos miembros de la familia de los opioides Eduardo Sánchez Martha León Olea Samuel Mucio Ramírez Carolina Miller Pérez Medicina ORL nociceptin orphanin FQ Opioid peptides opioid receptors Clonation of opioid receptors δ, µ and κ was followed byidentification and sequencing of and other member of theopioid family: the opioid receptor like-1 (ORL-1). Althoughthey share similarities with receptors µ, δ and κ, endogenousopioid ligands like ß-endorphin, dynorphin A and enkephalinsdo not have great affinity for this receptor. After the discoveryof ORL-1, its endogenous peptide was isolated. This peptidepresent a nanomolar affinity with its receptor. Two differentresearch groups reported this peptide: Meunier et al. (1995)called it nociceptin, and Reinscheid et al. (1995) called itorphanin FQ. ORL-1 and nociceptin/orphanin FQ (N/OFQ)have a wide anatomical distribution in the nervous system,mainly in the olfactory nucleus, cerebral cortex, hippocampus,septal region, basal ganglia, thalamus, hypothalamus, pons,medulla, cerebral peduncle, spinal cord and retina. Thisanatomical distribution evidences its role in different cerebralfunctions. Administration of N/OFQ may have hyperalgesic,allodinic, antiopioid or even analgesic effects. Basically, theeffects are both related with dose and administration route... 2001 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58262406 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.6 Vol.24 |
| format | Artículo científico |
| id | redalyc_58262406 |
| institution | Redalyc |
| language | en |
| publishDate | 2001 |
| publisher | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz |
| spellingShingle | El receptor ORL-1 y su péptido endógeno, la nociceptina/orfanina FQ. Nuevos miembros de la familia de los opioides Eduardo Sánchez Medicina ORL nociceptin orphanin FQ Opioid peptides opioid receptors El receptor ORL-1 y su péptido endógeno, la nociceptina/orfanina FQ. Nuevos miembros de la familia de los opioides Eduardo Sánchez Martha León Olea Samuel Mucio Ramírez Carolina Miller Pérez Medicina ORL nociceptin orphanin FQ Opioid peptides opioid receptors Clonation of opioid receptors δ, µ and κ was followed byidentification and sequencing of and other member of theopioid family: the opioid receptor like-1 (ORL-1). Althoughthey share similarities with receptors µ, δ and κ, endogenousopioid ligands like ß-endorphin, dynorphin A and enkephalinsdo not have great affinity for this receptor. After the discoveryof ORL-1, its endogenous peptide was isolated. This peptidepresent a nanomolar affinity with its receptor. Two differentresearch groups reported this peptide: Meunier et al. (1995)called it nociceptin, and Reinscheid et al. (1995) called itorphanin FQ. ORL-1 and nociceptin/orphanin FQ (N/OFQ)have a wide anatomical distribution in the nervous system,mainly in the olfactory nucleus, cerebral cortex, hippocampus,septal region, basal ganglia, thalamus, hypothalamus, pons,medulla, cerebral peduncle, spinal cord and retina. Thisanatomical distribution evidences its role in different cerebralfunctions. Administration of N/OFQ may have hyperalgesic,allodinic, antiopioid or even analgesic effects. Basically, theeffects are both related with dose and administration route... 2001 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58262406 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.6 Vol.24 |
| title | El receptor ORL-1 y su péptido endógeno, la nociceptina/orfanina FQ. Nuevos miembros de la familia de los opioides |
| topic | Medicina ORL nociceptin orphanin FQ Opioid peptides opioid receptors |
| url | https://www.redalyc.org/articulo.oa?id=58262406 |