Does the antidepressant-like effect of mirtazapine and venlafaxine differ between male and female rats?
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| Format: | Artículo científico |
| Langue: | en |
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Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
2020
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| _version_ | 1876469812256833536 |
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| author | Adriana Álvarez Silva |
| author_facet | Adriana Álvarez Silva |
| contents | Does the antidepressant-like effect of mirtazapine and venlafaxine differ between male and female rats? Adriana Álvarez Silva Alonso Fernández-Guasti Medicina Mirtazapine venlafaxine antidepressants sex differences forced swim test Introduction. Depression is a global health problem with nearly 350 million people affected, mainly women. However, nowadays a rising amount of men are being diagnosed. This makes necessary the screening of new treatment options that are effective in women as well as in men. Objective. To analyze if the administration of mirtazapine and venlafaxine to male and female rats shows a sex-related antidepressant-like effect, and the possible associated neurochemical mechanisms. Method. Mirtazapine (40 mg/kg) or venlafaxine (60 mg/kg) were administered subchronically to young adult male and female (ovariectomized and steroid-primed) rats, and their antidepressant-like effects were evaluated using the forced swim test (FST). The active behaviors, swimming and climbing, were also analyzed. Results. a) mirtazapine and venlafaxine reduced immobility in the FST in males and females; b) both antidepressants increased climbing and swimming in male rats; c) in female rats, mirtazapine and venlafaxine only increased swimming. Discussion and conclusion. In males, the effects of mirtazapine and venlafaxine seem to be produced by the activation of the serotonergic and noradrenergic systems. Conversely, estradiol might be modulating the mechanisms of action of both antidepressants in females producing only an increased swimming and suggesting the participation of the serotonergic system. 2020 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58262790002 https://www.redalyc.org/journal/582/58262790002/ https://www.redalyc.org/journal/582/58262790002/html/ https://www.redalyc.org/journal/582/58262790002/58262790002.epub https://www.redalyc.org/journal/582/58262790002/movil 10.17711/SM.0185-3325.2020.002 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.1 Vol.43 |
| format | Artículo científico |
| id | redalyc_58262790002 |
| institution | Redalyc |
| language | en |
| publishDate | 2020 |
| publisher | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz |
| spellingShingle | Does the antidepressant-like effect of mirtazapine and venlafaxine differ between male and female rats? Adriana Álvarez Silva Medicina Mirtazapine venlafaxine antidepressants sex differences forced swim test Does the antidepressant-like effect of mirtazapine and venlafaxine differ between male and female rats? Adriana Álvarez Silva Alonso Fernández-Guasti Medicina Mirtazapine venlafaxine antidepressants sex differences forced swim test Introduction. Depression is a global health problem with nearly 350 million people affected, mainly women. However, nowadays a rising amount of men are being diagnosed. This makes necessary the screening of new treatment options that are effective in women as well as in men. Objective. To analyze if the administration of mirtazapine and venlafaxine to male and female rats shows a sex-related antidepressant-like effect, and the possible associated neurochemical mechanisms. Method. Mirtazapine (40 mg/kg) or venlafaxine (60 mg/kg) were administered subchronically to young adult male and female (ovariectomized and steroid-primed) rats, and their antidepressant-like effects were evaluated using the forced swim test (FST). The active behaviors, swimming and climbing, were also analyzed. Results. a) mirtazapine and venlafaxine reduced immobility in the FST in males and females; b) both antidepressants increased climbing and swimming in male rats; c) in female rats, mirtazapine and venlafaxine only increased swimming. Discussion and conclusion. In males, the effects of mirtazapine and venlafaxine seem to be produced by the activation of the serotonergic and noradrenergic systems. Conversely, estradiol might be modulating the mechanisms of action of both antidepressants in females producing only an increased swimming and suggesting the participation of the serotonergic system. 2020 artículo científico 0185-3325 https://www.redalyc.org/articulo.oa?id=58262790002 https://www.redalyc.org/journal/582/58262790002/ https://www.redalyc.org/journal/582/58262790002/html/ https://www.redalyc.org/journal/582/58262790002/58262790002.epub https://www.redalyc.org/journal/582/58262790002/movil 10.17711/SM.0185-3325.2020.002 en http://www.redalyc.org/revista.oa?id=582 Salud Mental application/pdf Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz Salud Mental (México) Num.1 Vol.43 |
| title | Does the antidepressant-like effect of mirtazapine and venlafaxine differ between male and female rats? |
| topic | Medicina Mirtazapine venlafaxine antidepressants sex differences forced swim test |
| url | https://www.redalyc.org/articulo.oa?id=58262790002 https://www.redalyc.org/journal/582/58262790002/ https://www.redalyc.org/journal/582/58262790002/html/ https://www.redalyc.org/journal/582/58262790002/58262790002.epub https://www.redalyc.org/journal/582/58262790002/movil |