A rat model of the cognitive impairments in PARKINSON¿S disease
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| Format: | Artículo científico |
| Language: | en |
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Sociedad Mexicana de Análisis de la Conducta
2006
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| _version_ | 1876425096469413888 |
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| author | Claudio Da Cunha |
| author_facet | Claudio Da Cunha |
| contents | A rat model of the cognitive impairments in PARKINSON¿S disease Claudio Da Cunha Edmar Miyoshi Reinaldo N. Takahashi Rui D. S. Prediger Psicología MPTP rats memory learning cognition Although Parkinsons disease (PD) is classically considered to be a motorsystem disease, subtle cognitive impairments can be observed even duringthe early phases of PD. In this article we review behavioral and neurochemicalstudies on the cognitive alterations observed in rats treated with intranigralinfusion of the neurotoxin MPTP. The critical role of dopamine release in thedorsal striatum and its modulation by adenosine receptors is also reviewedas a potential strategy to treat the cognitive disabilities of PD patients who donot improve with levodopa therapy. Most of the impairments presented by ratstreated with intranigral infusion of MPTP are similar to those observed duringthe early phase of PD, when a moderate loss of nigral dopamine neurons(40-70%) results in sensory and memory defi cits with no major motor impairments. These animals also model the working memory and habit learningdefi cits, with long-term spatial (episodic) memories being mostly spared asobserved in non-demented PD patients. The intranigral infusion of MPTP inrats has led to the development of useful models, which do not present grossmotor impairments that would otherwise compromise the interpretation of theperformance of the animals in cognitive tasks. 2006 artículo científico 0185-4534 https://www.redalyc.org/articulo.oa?id=59332209 en http://www.redalyc.org/revista.oa?id=593 Revista Mexicana de Análisis de la Conducta application/pdf Sociedad Mexicana de Análisis de la Conducta Revista Mexicana de Análisis de la Conducta (México) Num.2 Vol.32 |
| format | Artículo científico |
| id | redalyc_59332209 |
| institution | Redalyc |
| language | en |
| publishDate | 2006 |
| publisher | Sociedad Mexicana de Análisis de la Conducta |
| spellingShingle | A rat model of the cognitive impairments in PARKINSON¿S disease Claudio Da Cunha Psicología MPTP rats memory learning cognition A rat model of the cognitive impairments in PARKINSON¿S disease Claudio Da Cunha Edmar Miyoshi Reinaldo N. Takahashi Rui D. S. Prediger Psicología MPTP rats memory learning cognition Although Parkinsons disease (PD) is classically considered to be a motorsystem disease, subtle cognitive impairments can be observed even duringthe early phases of PD. In this article we review behavioral and neurochemicalstudies on the cognitive alterations observed in rats treated with intranigralinfusion of the neurotoxin MPTP. The critical role of dopamine release in thedorsal striatum and its modulation by adenosine receptors is also reviewedas a potential strategy to treat the cognitive disabilities of PD patients who donot improve with levodopa therapy. Most of the impairments presented by ratstreated with intranigral infusion of MPTP are similar to those observed duringthe early phase of PD, when a moderate loss of nigral dopamine neurons(40-70%) results in sensory and memory defi cits with no major motor impairments. These animals also model the working memory and habit learningdefi cits, with long-term spatial (episodic) memories being mostly spared asobserved in non-demented PD patients. The intranigral infusion of MPTP inrats has led to the development of useful models, which do not present grossmotor impairments that would otherwise compromise the interpretation of theperformance of the animals in cognitive tasks. 2006 artículo científico 0185-4534 https://www.redalyc.org/articulo.oa?id=59332209 en http://www.redalyc.org/revista.oa?id=593 Revista Mexicana de Análisis de la Conducta application/pdf Sociedad Mexicana de Análisis de la Conducta Revista Mexicana de Análisis de la Conducta (México) Num.2 Vol.32 |
| title | A rat model of the cognitive impairments in PARKINSON¿S disease |
| topic | Psicología MPTP rats memory learning cognition |
| url | https://www.redalyc.org/articulo.oa?id=59332209 |