Effect of pH on the rheological response of reconstituted gastric mucin
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| Format: | Artículo científico |
| Language: | en |
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Universidad Nacional de Colombia
2015
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| author | J. Caicedo |
| author_facet | J. Caicedo |
| contents | Effect of pH on the rheological response of reconstituted gastric mucin J. Caicedo J. E. Perilla Ingeniería Mucin creep rheology potential elasticity The rheological response of reconstituted gastric mucin was studied by time dependent rheological experiments as function of pH. Mucin concentrations of 5 % and 10 % were prepared in buffer dispersions at pH of 1.15, 2.00, 2.55, 4.00 and 7.67. The isoelectric point was identified by z-potential between pH 2.00 to 2.55. Dynamic light scattering showed that as pH reduced, a second popula - tion of larger mucin aggregates was formed indicating the presence of new structures. Steady shear rheological measurements reflec - ted the pseudoplastic behavior of mucin dispersions and the effect of concentration on viscosity. Creep-recovery measurements were performed on the regenerated mucus at different levels of pH. By creep, it was possible to determine the values of zero-shear-viscosity of mucin suspensions, with higher precision and in a lower experimental time than steady shear measurements. Additionally, it was found that at pH ∼ 1.15, the viscosity of the mucus increased to high values, which is an indicative of a gel-like structure. By recovery experiments, it was possible to find that even the very low viscosities the mucin suspensions at pH ∼ 1.15 possessed a defined elastic character. By the use of a four-element mechanistic viscoelastic model, it was concluded that this elasticity underwent retardation due to the combined effect of viscous and elastic responses. 2015 artículo científico 0120-5609 https://www.redalyc.org/articulo.oa?id=64340413007 en http://www.redalyc.org/revista.oa?id=643 Ingeniería e Investigación application/pdf Universidad Nacional de Colombia Ingeniería e Investigación (Colombia) Num.2 Vol.35 |
| format | Artículo científico |
| id | redalyc_64340413007 |
| institution | Redalyc |
| language | en |
| publishDate | 2015 |
| publisher | Universidad Nacional de Colombia |
| spellingShingle | Effect of pH on the rheological response of reconstituted gastric mucin J. Caicedo Ingeniería Mucin creep rheology potential elasticity Effect of pH on the rheological response of reconstituted gastric mucin J. Caicedo J. E. Perilla Ingeniería Mucin creep rheology potential elasticity The rheological response of reconstituted gastric mucin was studied by time dependent rheological experiments as function of pH. Mucin concentrations of 5 % and 10 % were prepared in buffer dispersions at pH of 1.15, 2.00, 2.55, 4.00 and 7.67. The isoelectric point was identified by z-potential between pH 2.00 to 2.55. Dynamic light scattering showed that as pH reduced, a second popula - tion of larger mucin aggregates was formed indicating the presence of new structures. Steady shear rheological measurements reflec - ted the pseudoplastic behavior of mucin dispersions and the effect of concentration on viscosity. Creep-recovery measurements were performed on the regenerated mucus at different levels of pH. By creep, it was possible to determine the values of zero-shear-viscosity of mucin suspensions, with higher precision and in a lower experimental time than steady shear measurements. Additionally, it was found that at pH ∼ 1.15, the viscosity of the mucus increased to high values, which is an indicative of a gel-like structure. By recovery experiments, it was possible to find that even the very low viscosities the mucin suspensions at pH ∼ 1.15 possessed a defined elastic character. By the use of a four-element mechanistic viscoelastic model, it was concluded that this elasticity underwent retardation due to the combined effect of viscous and elastic responses. 2015 artículo científico 0120-5609 https://www.redalyc.org/articulo.oa?id=64340413007 en http://www.redalyc.org/revista.oa?id=643 Ingeniería e Investigación application/pdf Universidad Nacional de Colombia Ingeniería e Investigación (Colombia) Num.2 Vol.35 |
| title | Effect of pH on the rheological response of reconstituted gastric mucin |
| topic | Ingeniería Mucin creep rheology potential elasticity |
| url | https://www.redalyc.org/articulo.oa?id=64340413007 |