Immunomodulating effects of hot-water extract from Pleurotus ostreatus mycelium on cyclophosphamide treated mice
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| Natura: | Artículo científico |
| Lingua: | en |
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Colegio de Postgraduados
2003
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| _version_ | 1876467184067149824 |
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| author | R. C. Bermúdez |
| author_facet | R. C. Bermúdez |
| contents | Immunomodulating effects of hot-water extract from Pleurotus ostreatus mycelium on cyclophosphamide treated mice R. C. Bermúdez N. García H. J. Morris G. Llauradó R. Fontaine V. Tamayo J. Marcos Biología mycelium macrophage immunomodulator edible mushrooms cyclophosphamide With the view of developing new immunotherapeutic agents, there has been a recent upsurgeof interest in edible mushrooms. Hot-water extract (F-I: 43.6% w/w carbohydrate and w/wprotein) prepared from the mycelium of Pleurotus ostreatus was administeredintraperitoneally (i.p.) at 100 mg/kg for 7 days to Balb/c mice and cyclophosphamide (CY) at10 mg/kg was injected on the fifth day. The influence of F-I administration on theimmunosuppression caused by CY was evaluated on the eighth day. CY treated miceexhibited less pronounced immunosuppression and more rapid haematopoietic recoverywhen administered with F-I. The i.p. injection of F-I increased bone marrow cellularity (4.1 x106 vs. 1.5 x 106 per femur in saline control group, P< 0.01), the white blood cell counts (7.6 x 109vs. 4.8 x 109 cells/l, P< 0.05) and led to a two-fold increase in the number of endogenousmacroscopic colonies of hemopoietic tissue on the parietal surface of spleen (P< 0.05). F-Ienhanced the murine reticuloendothelial system as judged by the shorter rate of carbonclearance (4.23 vs. 6.18 min, P< 0.05). F-I increased the number of peritoneal exudate cells(P< 0.01) and stimulated in vivo murine macrophage phagocytic ratio (15.65% vs. 4.70%, P<0.01) and phagocytic index (1.06 vs. 0.12, P< 0.05). No toxicity signs such as hepatosplenomegalywere observed in F-I treated animals. These effects suggest that F-I could enhancehost-defense mechanisms in vivo. 2003 artículo científico 1534-2581 https://www.redalyc.org/articulo.oa?id=68515102 en http://www.redalyc.org/revista.oa?id=685 Micología Aplicada International application/pdf Colegio de Postgraduados Micología Aplicada International (México) Num.1 Vol.15 |
| format | Artículo científico |
| id | redalyc_68515102 |
| institution | Redalyc |
| language | en |
| publishDate | 2003 |
| publisher | Colegio de Postgraduados |
| spellingShingle | Immunomodulating effects of hot-water extract from Pleurotus ostreatus mycelium on cyclophosphamide treated mice R. C. Bermúdez Biología mycelium macrophage immunomodulator edible mushrooms cyclophosphamide Immunomodulating effects of hot-water extract from Pleurotus ostreatus mycelium on cyclophosphamide treated mice R. C. Bermúdez N. García H. J. Morris G. Llauradó R. Fontaine V. Tamayo J. Marcos Biología mycelium macrophage immunomodulator edible mushrooms cyclophosphamide With the view of developing new immunotherapeutic agents, there has been a recent upsurgeof interest in edible mushrooms. Hot-water extract (F-I: 43.6% w/w carbohydrate and w/wprotein) prepared from the mycelium of Pleurotus ostreatus was administeredintraperitoneally (i.p.) at 100 mg/kg for 7 days to Balb/c mice and cyclophosphamide (CY) at10 mg/kg was injected on the fifth day. The influence of F-I administration on theimmunosuppression caused by CY was evaluated on the eighth day. CY treated miceexhibited less pronounced immunosuppression and more rapid haematopoietic recoverywhen administered with F-I. The i.p. injection of F-I increased bone marrow cellularity (4.1 x106 vs. 1.5 x 106 per femur in saline control group, P< 0.01), the white blood cell counts (7.6 x 109vs. 4.8 x 109 cells/l, P< 0.05) and led to a two-fold increase in the number of endogenousmacroscopic colonies of hemopoietic tissue on the parietal surface of spleen (P< 0.05). F-Ienhanced the murine reticuloendothelial system as judged by the shorter rate of carbonclearance (4.23 vs. 6.18 min, P< 0.05). F-I increased the number of peritoneal exudate cells(P< 0.01) and stimulated in vivo murine macrophage phagocytic ratio (15.65% vs. 4.70%, P<0.01) and phagocytic index (1.06 vs. 0.12, P< 0.05). No toxicity signs such as hepatosplenomegalywere observed in F-I treated animals. These effects suggest that F-I could enhancehost-defense mechanisms in vivo. 2003 artículo científico 1534-2581 https://www.redalyc.org/articulo.oa?id=68515102 en http://www.redalyc.org/revista.oa?id=685 Micología Aplicada International application/pdf Colegio de Postgraduados Micología Aplicada International (México) Num.1 Vol.15 |
| title | Immunomodulating effects of hot-water extract from Pleurotus ostreatus mycelium on cyclophosphamide treated mice |
| topic | Biología mycelium macrophage immunomodulator edible mushrooms cyclophosphamide |
| url | https://www.redalyc.org/articulo.oa?id=68515102 |