Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more
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| Natura: | Artículo científico |
| Lingua: | en |
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Centro de investigaciones y Publicaciones Farmacéuticas
2012
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| _version_ | 1876464771103981568 |
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| author | Maia GAVRONSKI |
| author_facet | Maia GAVRONSKI |
| contents | Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more Maia GAVRONSKI Sirpa HARTIKAINEN Alexander ZHARKOVSKY Medicina Estonia Warfarin Outpatients Drug Interactions In Estonia, warfarin is widely prescribed by general practitioners to prevent and treat thromboembolic diseases. To date, there has been no systematic analysis of the potential risk of warfarin interactions with other drugs in the outpatient population. Objective: The aim of the study was to analyze the incidence of potential interactions in prescription schemes in Estonia in a cohort of outpatients receiving warfarin treatment. Methods: The retrospective study population included 203,646 outpatients aged 50 years or older of whom 7,175 received warfarin therapy. Patients who had used at least one prescription drug for aminimum period of 7 days concomitantly with warfarin were analyzed. Potential drug interactions were analyzed using Epocrates online, Stockley's Drug Interactions and domestic drug interaction databases. Results: The average number of drugs used concomitantly with warfarin was 4.8 (SD=1.9) (males: 4.7 SD=2.0, females: 4.9 SD=2.0). No potential interactions in treatment regimens were found in 38% of patients, one potential interactionwas observed in 29% and two or more potential interactions were observed in 33% of patients. The mean number of all potential interactions was 1.2 per patient and about the same in men and women. Potential interactions were associated with the number of drugs. Warfarin-related interactions were detected in 57% of patients, and the number of interactions related to warfarin per patient varied from 1 to 5. Most frequent were use of warfarin with NSAIDs (14%), followed by simvastatin (9%) and amiodarone (7%). Conclusion: This study shows that 57% of outpatients in Estonia receiving warfarin have drugs potentially interacting with warfarin in their treatment schemes. Most interactions (14%) with warfarin areassociated with the prescription of NSAIDs. 2012 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69023722003 en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.1 Vol.10 |
| format | Artículo científico |
| id | redalyc_69023722003 |
| institution | Redalyc |
| language | en |
| publishDate | 2012 |
| publisher | Centro de investigaciones y Publicaciones Farmacéuticas |
| spellingShingle | Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more Maia GAVRONSKI Medicina Estonia Warfarin Outpatients Drug Interactions Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more Maia GAVRONSKI Sirpa HARTIKAINEN Alexander ZHARKOVSKY Medicina Estonia Warfarin Outpatients Drug Interactions In Estonia, warfarin is widely prescribed by general practitioners to prevent and treat thromboembolic diseases. To date, there has been no systematic analysis of the potential risk of warfarin interactions with other drugs in the outpatient population. Objective: The aim of the study was to analyze the incidence of potential interactions in prescription schemes in Estonia in a cohort of outpatients receiving warfarin treatment. Methods: The retrospective study population included 203,646 outpatients aged 50 years or older of whom 7,175 received warfarin therapy. Patients who had used at least one prescription drug for aminimum period of 7 days concomitantly with warfarin were analyzed. Potential drug interactions were analyzed using Epocrates online, Stockley's Drug Interactions and domestic drug interaction databases. Results: The average number of drugs used concomitantly with warfarin was 4.8 (SD=1.9) (males: 4.7 SD=2.0, females: 4.9 SD=2.0). No potential interactions in treatment regimens were found in 38% of patients, one potential interactionwas observed in 29% and two or more potential interactions were observed in 33% of patients. The mean number of all potential interactions was 1.2 per patient and about the same in men and women. Potential interactions were associated with the number of drugs. Warfarin-related interactions were detected in 57% of patients, and the number of interactions related to warfarin per patient varied from 1 to 5. Most frequent were use of warfarin with NSAIDs (14%), followed by simvastatin (9%) and amiodarone (7%). Conclusion: This study shows that 57% of outpatients in Estonia receiving warfarin have drugs potentially interacting with warfarin in their treatment schemes. Most interactions (14%) with warfarin areassociated with the prescription of NSAIDs. 2012 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69023722003 en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.1 Vol.10 |
| title | Analysis of potential interactions between warfarin and prescriptions in Estonian outpatients aged 50 years or more |
| topic | Medicina Estonia Warfarin Outpatients Drug Interactions |
| url | https://www.redalyc.org/articulo.oa?id=69023722003 |