Evaluation of anti-tuberculosis induced adverse reactions in hospitalized patients
Saved in:
| Main Author: | |
|---|---|
| Format: | Artículo científico |
| Language: | en |
| Published: |
Centro de investigaciones y Publicaciones Farmacéuticas
2006
|
| Subjects: | |
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866586572904726528 |
|---|---|
| author | Elahe Kamali |
| author_facet | Elahe Kamali |
| contents | Evaluation of anti-tuberculosis induced adverse reactions in hospitalized patients Elahe Kamali Mahboubeh Hajiabdolbaghi Kheirollah Gholami Gloria Shalviri Medicina Iran Inpatients Tuberculosis Drug Toxicity Adverse Drug Reaction Reporting Systems Background: Tuberculosis has been one of thecommon diseases of human communities. Besidesof disease-related complications, there are seriousadverse reactions due to Anti-tuberculosis (Anti-TB)drug therapy.Objectives: To assess the rate of Adverse DrugReactions (ADRs) induced by Anti-TB drugs in theinfectious disease department for a period of oneyear. To detect serious and preventable recognizedADRs.Methods: All patients admitted to the infectiousdisease department at Imam tertiary teachinghospital in Iran who received Anti-TB drugs fromJuly 2001 to July 2002 entered the study. Thesepatients were monitored for ADRs during hospitalstay. The ADRs were then classified based onpatients and reactions factors. The causality andseverity of the reactions were determined usingNaranjo algorithm and Hartwig questionnaire,respectively.Results: During the study period, 83 patientsreceived Anti-TB drugs; of them 44 developed atleast one ADR. Total number of 81 ADRs wasdetected in this study. ADRs were recognized asthe major cause of hospital admission in 11 (13.3%)patients. The most frequent system-organ classaffected by ADRs was Liver and biliary system(37%). Hepatitis was observed in 21 (25.3%)patients leading to death in two patients.Conclusion: Anti-TB drugs could cause significantadverse effects both in quantity and severity leadingto hospitalization, prolonged hospital stay and evendeath. More attention is needed to prevent thesereactions. 2006 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69040306 en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.3 Vol.4 |
| format | Artículo científico |
| id | redalyc_69040306 |
| language | en |
| publishDate | 2006 |
| publisher | Centro de investigaciones y Publicaciones Farmacéuticas |
| spellingShingle | Evaluation of anti-tuberculosis induced adverse reactions in hospitalized patients Elahe Kamali Medicina Iran Inpatients Tuberculosis Drug Toxicity Adverse Drug Reaction Reporting Systems Evaluation of anti-tuberculosis induced adverse reactions in hospitalized patients Elahe Kamali Mahboubeh Hajiabdolbaghi Kheirollah Gholami Gloria Shalviri Medicina Iran Inpatients Tuberculosis Drug Toxicity Adverse Drug Reaction Reporting Systems Background: Tuberculosis has been one of thecommon diseases of human communities. Besidesof disease-related complications, there are seriousadverse reactions due to Anti-tuberculosis (Anti-TB)drug therapy.Objectives: To assess the rate of Adverse DrugReactions (ADRs) induced by Anti-TB drugs in theinfectious disease department for a period of oneyear. To detect serious and preventable recognizedADRs.Methods: All patients admitted to the infectiousdisease department at Imam tertiary teachinghospital in Iran who received Anti-TB drugs fromJuly 2001 to July 2002 entered the study. Thesepatients were monitored for ADRs during hospitalstay. The ADRs were then classified based onpatients and reactions factors. The causality andseverity of the reactions were determined usingNaranjo algorithm and Hartwig questionnaire,respectively.Results: During the study period, 83 patientsreceived Anti-TB drugs; of them 44 developed atleast one ADR. Total number of 81 ADRs wasdetected in this study. ADRs were recognized asthe major cause of hospital admission in 11 (13.3%)patients. The most frequent system-organ classaffected by ADRs was Liver and biliary system(37%). Hepatitis was observed in 21 (25.3%)patients leading to death in two patients.Conclusion: Anti-TB drugs could cause significantadverse effects both in quantity and severity leadingto hospitalization, prolonged hospital stay and evendeath. More attention is needed to prevent thesereactions. 2006 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69040306 en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.3 Vol.4 |
| title | Evaluation of anti-tuberculosis induced adverse reactions in hospitalized patients |
| topic | Medicina Iran Inpatients Tuberculosis Drug Toxicity Adverse Drug Reaction Reporting Systems |
| url | https://www.redalyc.org/articulo.oa?id=69040306 |