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| Formato: | Artículo científico |
| Lenguaje: | en |
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Centro de investigaciones y Publicaciones Farmacéuticas
2016
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| Acceso en línea: | https://www.redalyc.org/articulo.oa?id=69049099006 |
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| _version_ | 1866815650866921472 |
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| author | Tineshwaran VELVANATHAN |
| author_facet | Tineshwaran VELVANATHAN |
| contents | Simplification of HAART therapy on ambulatory HIV patients in Malaysia: a randomized controlled trial Tineshwaran VELVANATHAN Farida ISLAHUDIN Benedict L. SIM Nur A. TAHA Medicina Anti Malaysia Tenofovir Viral Load Benzoxazines Objective: Evaluate the impact of fixed-dose combination (FDC) containing emtricitabine (FTC), tenofovir (TDF), and efavirenz (EFV) versus a free-dose combination (FRC) of the same three drugs on clinical outcomes, adherence and quality of life in Malaysian outpatients with HIV. Methods: HIV patients (n=120) on highly active antiretroviral therapy (HAART) in the infectious disease clinic of Hospital Sungai Buloh were randomized to either FDC (n=60) or FRC (n=60). Morisky scores, health-related quality of life scores and clinical outcomes such as CD4 count and viral load were assessed in both groups at baseline and six months. Result: Patients on FDC (108 SD=1.1) had a significantly higher CD4 count increase compared to the FRC group (746.1 SD=36.3 vs 799.8 SD=33.8) (p <0.001). The viral load profile was unchanged and remained undetectable in both groups. The quality of life EQ-5D scores showed a positive correlation with CD4 counts in the FDC group (ρ=0.301, p=0.019) at six months. On the other hand, quality of life EQ-VAS scores was significantly associated with medication adherence in the FDC group at six months (ρ=0.749, p=0.05). However, no significant changes or associations were observed in the FRC group. Conclusion: Management of HAART using an FDC demonstrated a positive clinical outcome, adherence and quality of life within six months in local HIV patients. 2016 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69049099006 en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.4 Vol.14 |
| format | Artículo científico |
| id | redalyc_69049099006 |
| language | en |
| publishDate | 2016 |
| publisher | Centro de investigaciones y Publicaciones Farmacéuticas |
| spellingShingle | Simplification of HAART therapy on ambulatory HIV patients in Malaysia: a randomized controlled trial Tineshwaran VELVANATHAN Medicina Anti Malaysia Tenofovir Viral Load Benzoxazines Simplification of HAART therapy on ambulatory HIV patients in Malaysia: a randomized controlled trial Tineshwaran VELVANATHAN Farida ISLAHUDIN Benedict L. SIM Nur A. TAHA Medicina Anti Malaysia Tenofovir Viral Load Benzoxazines Objective: Evaluate the impact of fixed-dose combination (FDC) containing emtricitabine (FTC), tenofovir (TDF), and efavirenz (EFV) versus a free-dose combination (FRC) of the same three drugs on clinical outcomes, adherence and quality of life in Malaysian outpatients with HIV. Methods: HIV patients (n=120) on highly active antiretroviral therapy (HAART) in the infectious disease clinic of Hospital Sungai Buloh were randomized to either FDC (n=60) or FRC (n=60). Morisky scores, health-related quality of life scores and clinical outcomes such as CD4 count and viral load were assessed in both groups at baseline and six months. Result: Patients on FDC (108 SD=1.1) had a significantly higher CD4 count increase compared to the FRC group (746.1 SD=36.3 vs 799.8 SD=33.8) (p <0.001). The viral load profile was unchanged and remained undetectable in both groups. The quality of life EQ-5D scores showed a positive correlation with CD4 counts in the FDC group (ρ=0.301, p=0.019) at six months. On the other hand, quality of life EQ-VAS scores was significantly associated with medication adherence in the FDC group at six months (ρ=0.749, p=0.05). However, no significant changes or associations were observed in the FRC group. Conclusion: Management of HAART using an FDC demonstrated a positive clinical outcome, adherence and quality of life within six months in local HIV patients. 2016 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69049099006 en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.4 Vol.14 |
| title | Simplification of HAART therapy on ambulatory HIV patients in Malaysia: a randomized controlled trial |
| topic | Medicina Anti Malaysia Tenofovir Viral Load Benzoxazines |
| url | https://www.redalyc.org/articulo.oa?id=69049099006 |