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| Format: | Artículo científico |
| Language: | en |
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Centro de investigaciones y Publicaciones Farmacéuticas
2007
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| Online Access: | https://www.redalyc.org/articulo.oa?id=69050306 https://www.redalyc.org/journal/690/69050306/ https://www.redalyc.org/journal/690/69050306/html/ https://www.redalyc.org/journal/690/69050306/69050306.epub https://www.redalyc.org/journal/690/69050306/movil |
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| _version_ | 1866586767514140672 |
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| author | Krystal L. Edwards |
| author_facet | Krystal L. Edwards |
| contents | Evaluation of thiazide diuretic use as preferred therapy in uncomplicated essential hypertension patients Krystal L. Edwards Ronald S. Greene Marissa Escobar Quinones Medicina Economics Hypertension United States Pharmaceutical Sodium Chloride Symporter Inhibitors Thiazide diuretics are effective antihypertensivemedications shown to reduce the risk ofcardiovascular events and stroke. Despite being thepreferred choice for uncomplicated essentialhypertension, thiazide diuretics continue to beunderutilized.Methods: Uncomplicated essential hypertensionpatients taking a single antihypertensive medicationwere evaluated upon enrollment, diagnosis afterenrollment or initiation of therapy in treatment naïvepatients. Clinician prescribing habits weredetermined for both pre-existing and newlydiagnosed hypertensive patients. For the costsavings analysis, hydrochlorothiazide (HCTZ) 25mgdaily was selected as the preferred conversionmedication.Results: Four hundred seventy-eight patients wereincluded. ACE inhibitors were the most prescribedat 35.4% (n=169), followed by dihydropyridinecalcium channel blockers (DHP CCB) and thiazidediuretics, both at 20.3% (n=97). Only 12.9% (n=33)of patients with hypertension that were taking anantihypertensive medication upon enrollment wereeither continued or started on thiazide diuretictherapy. Newly diagnosed or treatment naïvepatients were prescribed a thiazide diuretic 28.8%(n=64) of the time. DHP CCB accounted for 58.8%of the total medication cost per month with thiazidediuretics responsible for 0.8% of the cost. If allpatients had been prescribed HCTZ 25mg daily,95.8% of the total medication cost per month couldhave been saved.Conclusions: Thiazide diuretics were underutilizedas preferred therapy in patients with pre-existing ornewly diagnosed uncomplicated essentialhypertension. While cost of therapy should not be*Ronald S. GREENE, PharmD, BCPS, CDE. AssistantProfessor of Pharmacy Practice/Advanced PracticePharmacist in Primary Care. School of Pharmacy, TexasTech University Health Sciences Center; and VeteransAffairs North Texas Health Care System. Dallas, TX(USA).Marissa ESCOBAR QUINONES. PharmD. AssistantProfessor of Pharmacy Practice. School of Pharmacy,Texas Tech University Health Sciences Center. Dallas, TX(USA).Krystal L. EDWARDS, PharmD, BCPS. AssistantProfessor of Pharmacy Practice/Advanced PracticePharmacist in Primary Care. School of Pharmacy, TexasTech University Health Sciences Center; and VeteransAffairs North Texas Health Care System. Dallas, TX(USA).the sole reason for medication selection, thiazidediuretics are an attractive option and should beconsidered as a preferred therapy in this patientpopulatio 2007 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69050306 https://www.redalyc.org/journal/690/69050306/ https://www.redalyc.org/journal/690/69050306/html/ https://www.redalyc.org/journal/690/69050306/69050306.epub https://www.redalyc.org/journal/690/69050306/movil en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.3 Vol.5 |
| format | Artículo científico |
| id | redalyc_69050306 |
| language | en |
| publishDate | 2007 |
| publisher | Centro de investigaciones y Publicaciones Farmacéuticas |
| spellingShingle | Evaluation of thiazide diuretic use as preferred therapy in uncomplicated essential hypertension patients Krystal L. Edwards Medicina Economics Hypertension United States Pharmaceutical Sodium Chloride Symporter Inhibitors Evaluation of thiazide diuretic use as preferred therapy in uncomplicated essential hypertension patients Krystal L. Edwards Ronald S. Greene Marissa Escobar Quinones Medicina Economics Hypertension United States Pharmaceutical Sodium Chloride Symporter Inhibitors Thiazide diuretics are effective antihypertensivemedications shown to reduce the risk ofcardiovascular events and stroke. Despite being thepreferred choice for uncomplicated essentialhypertension, thiazide diuretics continue to beunderutilized.Methods: Uncomplicated essential hypertensionpatients taking a single antihypertensive medicationwere evaluated upon enrollment, diagnosis afterenrollment or initiation of therapy in treatment naïvepatients. Clinician prescribing habits weredetermined for both pre-existing and newlydiagnosed hypertensive patients. For the costsavings analysis, hydrochlorothiazide (HCTZ) 25mgdaily was selected as the preferred conversionmedication.Results: Four hundred seventy-eight patients wereincluded. ACE inhibitors were the most prescribedat 35.4% (n=169), followed by dihydropyridinecalcium channel blockers (DHP CCB) and thiazidediuretics, both at 20.3% (n=97). Only 12.9% (n=33)of patients with hypertension that were taking anantihypertensive medication upon enrollment wereeither continued or started on thiazide diuretictherapy. Newly diagnosed or treatment naïvepatients were prescribed a thiazide diuretic 28.8%(n=64) of the time. DHP CCB accounted for 58.8%of the total medication cost per month with thiazidediuretics responsible for 0.8% of the cost. If allpatients had been prescribed HCTZ 25mg daily,95.8% of the total medication cost per month couldhave been saved.Conclusions: Thiazide diuretics were underutilizedas preferred therapy in patients with pre-existing ornewly diagnosed uncomplicated essentialhypertension. While cost of therapy should not be*Ronald S. GREENE, PharmD, BCPS, CDE. AssistantProfessor of Pharmacy Practice/Advanced PracticePharmacist in Primary Care. School of Pharmacy, TexasTech University Health Sciences Center; and VeteransAffairs North Texas Health Care System. Dallas, TX(USA).Marissa ESCOBAR QUINONES. PharmD. AssistantProfessor of Pharmacy Practice. School of Pharmacy,Texas Tech University Health Sciences Center. Dallas, TX(USA).Krystal L. EDWARDS, PharmD, BCPS. AssistantProfessor of Pharmacy Practice/Advanced PracticePharmacist in Primary Care. School of Pharmacy, TexasTech University Health Sciences Center; and VeteransAffairs North Texas Health Care System. Dallas, TX(USA).the sole reason for medication selection, thiazidediuretics are an attractive option and should beconsidered as a preferred therapy in this patientpopulatio 2007 artículo científico 1885-642X https://www.redalyc.org/articulo.oa?id=69050306 https://www.redalyc.org/journal/690/69050306/ https://www.redalyc.org/journal/690/69050306/html/ https://www.redalyc.org/journal/690/69050306/69050306.epub https://www.redalyc.org/journal/690/69050306/movil en http://www.redalyc.org/revista.oa?id=690 Pharmacy Practice application/pdf Centro de investigaciones y Publicaciones Farmacéuticas Pharmacy Practice (España) Num.3 Vol.5 |
| title | Evaluation of thiazide diuretic use as preferred therapy in uncomplicated essential hypertension patients |
| topic | Medicina Economics Hypertension United States Pharmaceutical Sodium Chloride Symporter Inhibitors |
| url | https://www.redalyc.org/articulo.oa?id=69050306 https://www.redalyc.org/journal/690/69050306/ https://www.redalyc.org/journal/690/69050306/html/ https://www.redalyc.org/journal/690/69050306/69050306.epub https://www.redalyc.org/journal/690/69050306/movil |